Results 241 to 250 of about 194,742 (384)

A patient‐derived orthotopic xenograft model unveils metastatic dynamics in head and neck squamous cell carcinoma

The FEBS Journal, EarlyView.
Metastasis in head and neck squamous cell carcinoma (HNSC) poses significant clinical challenges. This proof‐of‐concept study establishes patient‐derived orthotopic xenografts (PDOXs) as advanced models that closely replicate primary HNSC tumours, including local lymph node metastasis and the intricate cancer–stroma interaction.
Yuchen Bai, Benjamin Blyth, Jarryd Boath, Qiji Deng, Ruihong Huang, Charbel Darido   +5 more
wiley   +1 more source

Human Helicase DDX5 is Hijacked by SARS-CoV‑2 Nsp13 Helicase to Enhance RNA Unwinding. [PDF]

ACS Omega
Barra G, Ruggiero A, Napolitano V, Lodola C, Secchi M, Pallotta MM, Benincasa V, Leone F, Maga G, Berisio R.   +9 more
europepmc   +1 more source

The HRIGRXXR region of the DEAD box RNA helicase eukaryotic translation initiation factor 4A is required for RNA binding and ATP hydrolysis.

, 1993
Arnim Pause, Nathalie Méthot, Nahum Sonenberg   +2 more
openalex   +1 more source

Direction of the DNA‐unwinding reaction catalysed by Escherichia coli DNA helicase II [PDF]

, 1990
Petra GEORGI‐GEISBERGER, Hartmut Hoffmann‐Berling   +1 more
openalex   +1 more source

Ubiquitination dynamics in human tumour viruses: Viral infection, oncogenesis and antiviral therapy

The FEBS Journal, EarlyView.
The ubiquitin system is essential for cellular homeostasis and regulates many processes. Viruses, including oncogenic ones, exploit or evade this system to survive and replicate. This review explores how human tumour viruses manipulate the ubiquitination system to complete their life cycle, evade immunity and promote cancer.
Oscar Trejo‐Cerro, Martina Bergant Marušič, Justyna Broniarczyk   +2 more
wiley   +1 more source

Structural insights into transcriptional regulation by the helicase RECQL5. [PDF]

Nat Struct Mol Biol
Florez Ariza AJ, Lue NZ, Grob P, Kaeser B, Fang J, Kassube SA, Nogales E.   +6 more
europepmc   +1 more source

Medical genetics: advances in brief: ERCC6, a member of a subfamily of putative helicases, is involved in Cockayne's syndrome and preferential repair of active genes [PDF]

, 1993
Nalin Thakker
openalex   +1 more source

Adoption of non‐related goslings and intergenerational family cohesion among Greenland White‐fronted Geese (Anser albifrons flavirostris)

Ibis, EarlyView.
Greenland White‐fronted Geese Anser albifrons flavirostris exhibit prolonged parent–offspring and sibling–sibling associations, suggesting fitness advantages to such behaviour, so we used reduced representation genome sequence data to determine the degree to which marked flock members observed associating in apparent parent–offspring and sibling ...
Robert E. Wilson, Sarah A. Sonsthagen, Alyn J. Walsh, Anthony D. Fox   +3 more
wiley   +1 more source

Quantitative functional profiling of ERCC2 mutations deciphers cisplatin sensitivity in bladder cancer. [PDF]

J Clin Invest
Börcsök J, Gopaul D, Devesa-Serrano D, Mooser C, Jonsson N, Cagiada M, Stormoen DR, Ataya MN, Guercio BJ, Kaimakliotis HZ, Iyer G, Lindorff-Larsen K, Dyrskjøt L, Mouw KW, Szallasi Z, Sørensen CS.   +15 more
europepmc   +1 more source

Innate Immune Activation Is a Strong Suppressor of CCL22 and Impedes Regulatory T Cell–Dendritic Cell Interaction

Immunology, EarlyView.
During homeostasis, CCL22 is secreted by dendritic cells (DC), which mediate contacts between regulatory T cells (Treg) and DC to maintain immune balance. Activation of innate immunity via microbes or pattern recognition receptor (PRR) agonists induces the secretion of several soluble factors (e.g., type I and II interferons, IL‐10), which mediate ...
Ignazio Piseddu, Jan Gärtig, Stephan Eiber, Stefan Moder, Raffael Thaler, Matthias Thaler, Juliane Gruen, Marlies Vornhülz, Kevin Bahner, Luana Messa, Benjamin Kühnemuth, Jennifer Müller, Konstantin Schnell, Antonia Beimert, Carolin Perleberg, Natascha Röhrle, Maximilian Martin Ludwig Knott, Linda Hammann, Vanessa Wittmann, Patrick Layritz, Moritz Rapp, Carole Bourquin, Julia Mayerle, Stefan Endres, David Anz   +24 more
wiley   +1 more source