Results 51 to 60 of about 215,192 (350)

Arabidopsis RecQl4A suppresses homologous recombination and modulates DNA damage responses [PDF]

, 2005
The DNA damage response and DNA recombination are two interrelated mechanisms involved in maintaining the integrity of the genome, but in plants they are poorly understood.
Bachrati, Bagherieh-Najjar, Bai, Blackburn, Bundock, Cohen, Courcelle, Cromie, De Silva, Dellaporta, Ellis, Fitzgerald, Frei, Gallego, Gallego, Gallego, Gherbi, Gray, Hanada, Hanin, Harrigan, Hartung, Henson, Imamura, Jackson, Jacques Hille, Johnson, Kitao, Krysan, Li, Lovett, Lowndes, McGlynn, McHugh, Mengiste, Michel, Mohammad B. Bagherieh-Najjar, Nakayama, Nakayama, Nugent, Onno M.H. Vries, Osborn, Pastink, Paul P. Dijkwel, Pierce, Puchta, Reiss, Riha, Riha, Rothstein, Sambrook, Seigneur, Sengupta, Sessions, Simon, Sinclair, Sladek, Sundaresan, Swoboda, Tercero, Ui, Valvekens, Watt, Wu, Yamagata   +64 more
core   +6 more sources

Dynamics and Conformations of a Full-Length CRESS-DNA Replicase

Viruses, 2023
Circular Rep-encoding single-stranded DNA (CRESS-DNA) viruses encode for a Replicase (Rep) that is essential for viral replication. Rep is a helicase with three domains: an endonuclease, an oligomeric, and an ATPase domain (ED, OD, and AD).
Elvira Tarasova, Reza Khayat
doaj   +1 more source

Werner syndrome helicase is a selective vulnerability of microsatellite instability-high tumor cells

bioRxiv, 2019
Targeted cancer therapy is based on exploiting selective dependencies of tumor cells. By leveraging recent large-scale genomic profiling and functional screening of cancer cell lines we identified Werner syndrome helicase (WRN) as a novel specific ...
Simone Lieb, Silvia Blaha-Ostermann, Elisabeth Kamper, Janine Rippka, C. Schwarz, Katharina Ehrenhöfer-Wölfer, A. Schlattl, Andreas Wernitznig, J. Lipp, Kota Nagasaka, Petra van der Lelij, G. Bader, M. Koi, A. Goel, Ralph A. Neumüller, J. Peters, N. Kraut, M. Pearson, M. Petronczki, Simon Wöhrle   +19 more
semanticscholar   +1 more source

Homologous Recombination: To Fork and Beyond [PDF]

, 2018
Accurate completion of genome duplication is threatened by multiple factors that hamper the advance and stability of the replication forks. Cells need to tolerate many of these blocking lesions to timely complete DNA replication, postponing their repair ...
Prado Velasco, José Félix
core   +1 more source

Interaction and assembly of the DNA replication core proteins of Kaposi’s sarcoma-associated herpesvirus

Microbiology Spectrum, 2023
Kaposi’s sarcoma-associated herpesvirus (KSHV) encodes six highly conserved core replication proteins essential for the viral lytic DNA synthesis, including ORF6 (single-stranded DNA-binding protein), ORF9 (DNA polymerase), ORF40/41 (primase-associated ...
Lee-Wen Chen, Shie-Shan Wang, Li-Yu Chen, Hsiao-Yun Huang, Si-min He, Chien-Hui Hung, Chun-Liang Lin, Pey-Jium Chang   +7 more
doaj   +1 more source

The mechanism of RNA duplex recognition and unwinding by DEAD-box helicase DDX3X

Nature Communications, 2019
DEAD-box helicases (DDXs) regulate RNA processing and metabolism by unwinding short double-stranded (ds) RNAs. Sharing a helicase core composed of two RecA-like domains (D1D2), DDXs function in an ATP-dependent, non-processive manner.
He Song, X. Ji
semanticscholar   +1 more source

Helicase Domain of West Nile Virus NS3 Protein Plays a Role in Inhibition of Type I Interferon Signalling

Viruses, 2017
West Nile virus (WNV) is a neurotropic flavivirus that can cause encephalitis in mammalian and avian hosts. In America, the virulent WNV strain (NY99) is causing yearly outbreaks of encephalitis in humans and horses, while in Australia the less virulent ...
Yin Xiang Setoh, Parthiban Periasamy, Nias Yong Gao Peng, Alberto A. Amarilla, Andrii Slonchak, Alexander A. Khromykh   +5 more
doaj   +1 more source

Role of the Schizosaccharomyces pombe F-box DNA helicase in processing recombination intermediates. [PDF]

, 2005
In an effort to identify novel genes involved in recombination repair, we isolated fission yeast Schizosaccharomyces pombe mutants sensitive to methyl methanesulfonate (MMS) and a synthetic lethal with rad2.
Carr, Antony M, Furukawa, Fumiko, Iwasaki, Hiroshi, Morishita, Takashi, Sakaguchi, Chikako, Shinagawa, Hideo, Toda, Takashi   +6 more
core   +2 more sources

SIRT7 and the DEAD-box helicase DDX21 cooperate to resolve genomic R loops and safeguard genome stability

Genes & Development, 2017
Here, Song et al. show that the DEAD-box RNA helicase DDX21 efficiently unwinds RNA/DNA hybrids (R loops) in vivo and in vitro and prevents DNA damage. Their findings reveal a novel mechanism by which accumulation of R loops by DDX21 depletion leads to ...
Chenlin Song, A. Hotz-Wagenblatt, R. Voit, I. Grummt   +3 more
semanticscholar   +1 more source

Discovery of Small Molecules Against Foot-and-Mouth Disease Virus Replication by Targeting 2C Helicase Activity

Viruses
Background: The 2C protein of foot-and-mouth disease virus (FMDV), a member of helicase superfamily 3 (SF3), drives viral genome replication and serves as a critical target for antiviral drug development. Methods: A fluorescence resonance energy transfer
Saisai Zhou, Suyu Mu, Shuqi Yu, Yang Tian, Sijia Lu, Zhen Li, Hao Wu, Jiaying Zhao, Huanchun Chen, Shiqi Sun, Yunfeng Song   +10 more
doaj   +1 more source