Results 61 to 70 of about 194,742 (384)
eLife, 2022 Following infection of bacterial cells, bacteriophage modulate double-stranded DNA break repair pathways to protect themselves from host immunity systems and prioritise their own recombinases.
Martin Wilkinson +5 more
doaj +1 more source
The mechanism of RNA duplex recognition and unwinding by DEAD-box helicase DDX3X
Nature Communications, 2019 DEAD-box helicases (DDXs) regulate RNA processing and metabolism by unwinding short double-stranded (ds) RNAs. Sharing a helicase core composed of two RecA-like domains (D1D2), DDXs function in an ATP-dependent, non-processive manner.
He Song, X. Ji
semanticscholar +1 more source
Structure of a translocation signal domain mediating conjugative transfer by Type IV secretion systems [PDF]
, 2013 Relaxases are proteins responsible for the transfer of plasmid and chromosomal DNA from one bacterium to another during conjugation. They covalently react with a specific phosphodiester bond within DNA origin of transfer sequences, forming a nucleo ...
Gruber, C.J. +7 more
core +1 more source
Genes & Development, 2017 Here, Song et al. show that the DEAD-box RNA helicase DDX21 efficiently unwinds RNA/DNA hybrids (R loops) in vivo and in vitro and prevents DNA damage. Their findings reveal a novel mechanism by which accumulation of R loops by DDX21 depletion leads to ...
Chenlin Song +3 more
semanticscholar +1 more source
Terminating the replication helicase
Nature Cell Biology, 2017 A feature of the cell cycle is that the events of one cycle must be reset before the next one begins. A study now shows that the replication machinery is removed from fully replicated DNA by a conserved ubiquitin- and CDC48 (also known as p97)-dependent pathway. This explains how eukaryotic chromosomes are returned to the unreplicated state.
Gaggioli, Vincent, Zegerman, Philip
openaire +4 more sources
The ATPase cycle of PcrA helicase and its coupling to translocation on DNA. [PDF]
, 2009 The superfamily 1 bacterial helicase PcrA has a role in the replication of certain plasmids, acting with the initiator protein (RepD) that binds to and nicks the double-stranded origin of replication.
Martinez-Senac, Maria M +3 more
core +1 more source
Frontiers in Veterinary ScienceGenome replication is a key step in the coronavirus life cycle and requires the involvement of a range of virally encoded non-structural proteins. The non-structural protein 13 (Nsp13) of coronaviruses is a highly conserved helicase and is considered an ...
Chengcheng Wu +4 more
doaj +1 more source
Sweet Melody or Jazz? Transcription Around DNA Double-Strand Breaks
Frontiers in Molecular Biosciences, 2021 Genomic integrity is continuously threatened by thousands of endogenous and exogenous damaging factors. To preserve genome stability, cells developed comprehensive DNA damage response (DDR) pathways that mediate the recognition of damaged DNA lesions ...
Qilin Long +2 more
doaj +1 more source
Structural insights into RNA recognition by the Chikungunya virus nsP2 helicase
Proceedings of the National Academy of Sciences of the United States of America, 2019 Significance The multifunctional helicase-protease protein nsP2 of Chikungunya virus (CHIKV) plays vital roles in viral RNA replication and virus–host interactions.
Y. Law +8 more
semanticscholar +1 more source
Zika virus NS3 is a canonical RNA helicase stimulated by NS5 RNA polymerase
Nucleic Acids Research, 2019 Zika virus is a positive single-strand RNA virus whose replication involved RNA unwinding and synthesis. ZIKV NS3 contains a helicase domain, but its enzymatic activity is not fully characterized. Here, we established a dsRNA unwinding assay based on the
Shanshan Xu +7 more
semanticscholar +1 more source