Results 61 to 70 of about 215,192 (350)

DNA Helicase–Polymerase Coupling in Bacteriophage DNA Replication

Viruses, 2021
Bacteriophages have long been model systems to study the molecular mechanisms of DNA replication. During DNA replication, a DNA helicase and a DNA polymerase cooperatively unwind the parental DNA.
Chen-Yu Lo, Yang Gao
doaj   +1 more source

Structural insights into RNA recognition by the Chikungunya virus nsP2 helicase

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance The multifunctional helicase-protease protein nsP2 of Chikungunya virus (CHIKV) plays vital roles in viral RNA replication and virus–host interactions.
Y. Law, Age Utt, Yaw Bia Tan, Jie Zheng, Sainan Wang, M. Chen, P. Griffin, A. Merits, D. Luo   +8 more
semanticscholar   +1 more source

Dna2 is a structure-specific nuclease, with affinity for 5'-flap intermediates [PDF]

, 2010
Dna2 is a nuclease/helicase with proposed roles in DNA replication, double-strand break repair and telomere maintenance. For each role Dna2 is proposed to process DNA substrates with a 5'-flap.
Aguilera, Ayyagari, Bae, Bae, Bae, Balakrishnan, Bell, Bonetti, Budd, Budd, Budd, Budd, Budd, Budd, Ceska, Chapados, Dervan, Devos, Duxin, Garg, Harrington, Hohl, Hosfield, Jason A. Stewart, Judith L. Campbell, Kao, Kao, Kao, Kim, Kim, Lee, Liao, Liu, Liu, Liu, Masuda-Sasa, Masuda-Sasa, Mathews, Moser, Mueser, Murante, Qiu, Robert A. Bambara, Robertson, Shrader, Stewart, Stewart, Stewart, Szczesny, Weitao, Williams, Xu, Zheng, Zhu, Zuker   +54 more
core   +2 more sources

Human RPA activates BLM’s bidirectional DNA unwinding from a nick

eLife, 2020
BLM is a multifunctional helicase that plays critical roles in maintaining genome stability. It processes distinct DNA substrates, but not nicked DNA, during many steps in DNA replication and repair. However, how BLM prepares itself for diverse functions
Zhenheng Qin, Lulu Bi, Xi-Miao Hou, Siqi Zhang, Xia Zhang, Ying Lu, Ming Li, Mauro Modesti, Xu-Guang Xi, Bo Sun   +9 more
doaj   +1 more source

Potential Adjuvant Therapeutic Effect of Lactobacillus plantarum Probio-88 Postbiotics against SARS-COV-2

Vaccines, 2021
In response to the ongoing COVID-19 pandemic, the global effort to develop high efficacy countermeasures to control the infection are being conducted at full swing.
Irfan A. Rather, Sy-Bing Choi, Majid Rasool Kamli, Khalid Rehman Hakeem, Jamal S. M. Sabir, Yong-Ha Park, Yan-Yan Hor   +6 more
doaj   +1 more source

Crystal structure of Middle East respiratory syndrome coronavirus helicase

PLoS Pathogens, 2017
Middle East respiratory syndrome coronavirus (MERS-CoV) remains a threat to public health worldwide; however, effective vaccine or drug against CoVs remains unavailable. CoV helicase is one of the three evolutionary most conserved proteins in nidoviruses,
W. Hao, J. Wojdyla, R. Zhao, Ruiyun Han, Rajat S Das, Ivan Zlatev, M. Manoharan, Meitian Wang, S. Cui   +8 more
semanticscholar   +1 more source

Structure of a translocation signal domain mediating conjugative transfer by Type IV secretion systems [PDF]

, 2013
Relaxases are proteins responsible for the transfer of plasmid and chromosomal DNA from one bacterium to another during conjugation. They covalently react with a specific phosphodiester bond within DNA origin of transfer sequences, forming a nucleo ...
Gruber, C.J., Ilangovan, Aravindan, Lang, S., Redzej, Adam, Topf, Maya, Waksman, Gabriel, Zangger, K., Zechner, E.L.   +7 more
core   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Identification of a novel nuclease activity in human DDX49 helicase

Royal Society Open Science
Human DDX49 is an emerging target in cancer progression and retroviral diseases through its essential roles in nucleolar RNA processing. Here, we identify nuclease activity of human DDX49, which requires active site aspartate residues within a conserved ...
Ashley J. Parkes, Sabesan Anandavijayan, Anna Lou-Hing, Olivia Downs, Tom Killelea, Louise Martin, Fiorela Kapllanaj, Edward L. Bolt   +7 more
doaj   +1 more source

Zika virus NS3 is a canonical RNA helicase stimulated by NS5 RNA polymerase

Nucleic Acids Research, 2019
Zika virus is a positive single-strand RNA virus whose replication involved RNA unwinding and synthesis. ZIKV NS3 contains a helicase domain, but its enzymatic activity is not fully characterized. Here, we established a dsRNA unwinding assay based on the
Shanshan Xu, Y. Ci, Leijie Wang, Yang Yang, Lei-Liang Zhang, Caimin Xu, C. Qin, Lei Shi   +7 more
semanticscholar   +1 more source