Results 81 to 90 of about 191,259 (287)
European Journal of Biology, 2022 Objective: Coronavirus Disease 2019 (COVID19) is a viral disease caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS CoV-2). The high mutation propensity of the SARS CoV-2 genome is one of the biggest threats to the long-term validity of ...
Ekrem Akbulut
doaj +1 more source
Localisation of the human hSuv3p helicase in the mitochondrial matrix and its preferential unwinding of dsDNA [PDF]
, 2002 We characterised the human hSuv3p protein belonging to the family of NTPases/helicases. In yeast mitochondria the hSUV3 orthologue is a component of the degradosome complex and participates in mtRNA turnover and processing, while in Caenorhabditis ...
Awiszus, K. +10 more
core +2 more sources
Homology sensing via non-linear amplification of sequence-dependent pausing by RecQ helicase
eLife, 2019 RecQ helicases promote genomic stability through their unique ability to suppress illegitimate recombination and resolve recombination intermediates. These DNA structure-specific activities of RecQ helicases are mediated by the helicase-and-RNAseD like C-
Yeonee Seol +3 more
doaj +1 more source
Targeting the eIF4A RNA helicase blocks translation of the MUC1-C oncoprotein [PDF]
, 2012 The oncogenic MUC1-C subunit is aberrantly overexpressed in most human breast cancers by mechanisms that are not well understood. The present studies demonstrate that stimulation of non- malignant MCF-10A cells with epidermal growth factor (EGF) or ...
Jin, Caining +4 more
core +1 more source
From promoting to inhibiting: diverse roles of helicases in HIV-1 Replication
Retrovirology, 2012 Helicases hydrolyze nucleotide triphosphates (NTPs) and use the energy to modify the structures of nucleic acids. They are key players in every cellular process involving RNA or DNA. Human immunodeficiency virus type 1 (HIV-1) does not encode a helicase,
Lorgeoux Rene-Pierre +2 more
doaj +1 more source
Nature Communications, 2018 Mutations in BLM in Bloom Syndrome patients predispose them to multiple types of cancers. Here we report that BLM is recruited in a biphasic manner to annotated DSBs. BLM recruitment is dependent on the presence of NBS1, MRE11 and ATM. While ATM activity
V. Tripathi +8 more
semanticscholar +1 more source
Single Strand Annealing and ATP-independent Strand Exchange Activities of Yeast and Human DNA2: possible role in Ozaki fragment maturation [PDF]
, 2006 The Dna2 protein is a multifunctional enzyme with 5'-3' DNA helicase, DNA-dependent ATPase, 3' exo/endonuclease, and 5' exo/endonuclease. The enzyme is highly specific for structures containing single-stranded flaps adjacent to duplex regions.
Campbell, Judith L. +2 more
core
Helicase processivity and not the unwinding velocity exhibits universal increase with force [PDF]
, 2015 Helicases, involved in a number of cellular functions, are motors that translocate along singlestranded nucleic acid and couple the motion to unwinding double-strands of a duplex nucleic acid.
Chakrabarti, Shaon +2 more
core +2 more sources
The Journal of Cell Biology, 2005 Some helicases continually bang their heads against the wall, if a new report from Sua Myong, Taekjip Ha (University of Illinois, Urbana-Champaign, IL), and colleagues is any indication. The Rep helicase, the group finds, repeatedly motors along a track of DNA, hits an obstacle, and returns to square one.
openaire +3 more sources
Proceedings of the National Academy of Sciences of the United States of America, 2018 Significance Aberrant or unwanted transcripts can be degraded by the RNA exosome with the help of the nuclear exosome-targeting (NEXT) complex. NEXT, composed of RNA-binding protein RBM7, scaffold ZCCHC8, and helicase MTR4, is implicated in stress ...
M. Puno +3 more
semanticscholar +1 more source