Results 61 to 70 of about 306,089 (345)

CagA-specific Gastric CD8+ Tissue-Resident T Cells Control Helicobacter pylori During the Early Infection Phase [PDF]

, 2022
Maximilian R. Koch, Ruolan Gong, Verena Friedrich, Veronika Engelsberger, Lorenz Kretschmer, Andreas Wanisch, Sebastian Jarosch, Anna Ralser, Bob Lugen, Michael Quante, Michael Vieth, Riccardo Vasapolli, Christian Schulz, Veit R. Buchholz, Dirk H. Busch, Raquel Mejías‐Luque, Markus Gerhard   +16 more
openalex   +1 more source

RELA Ablation Contributes to Progression of Hepatocellular Carcinoma with TP53R249S Mutation and is a Potential Therapeutic Target

Advanced Science, EarlyView.
Genome‐wide CRISPR/Cas9 based screening identified RELA as a key tumor suppressor in TP53R249S‐mutant HCC. Its loss promotes tumorigenesis and metastasis via DVL1‐mediated Wnt/β‐catenin activation, while its agonist betulinic acid suppresses tumor progression.
Zhiping Wu, Zhe Wang, Diwei Zheng, Yongfang Zheng, Zhiwu Jiang, Jiang Lv, Yueqin Zhu, Heng Jia, Ziyuan Duan, Tingjie Yuan, Qiting Wu, Youguo Long, Shouheng Lin, Yao Yao, Georgia Carson, Jean P. Thiery, Kwan Man, Peng Li   +17 more
wiley   +1 more source

Discovery of a Potent and Selective TEAD Degrader with Durable Degradation Activity

Advanced Science, EarlyView.
KG‐FP‐003, a highly potent TEAD‐YAP PROTAC derived from the patented inhibitor is developed. It selectively degrades endogenous TEAD proteins in HiBiT systems without IMiD‐related off‐target effects. Screening across 867 cancer cell lines revealed broad and superior anti‐tumor activity, highlighting its therapeutic potential through targeted TEAD ...
Linhui Cao, Jing Yang, Yuhang Liu, Xiaotong Chen, Yufang Shi, Yunshuo Zhao, Yong Zhang, Jian Chen, Bowen Li, Wuqiang Wen, Lu Chen, Bo Peng, Lu Huang, Yanli Sun, Lixin Zhou, Matthew G Rees, Melissa M Ronan, Jennifer A Roth, Zhixiang Guo, Jing Xing, Guangya Zhu, Yazhou Wang, Baishan Jiang, Jing Lu, Kehao Zhao, Wenchao Lu   +25 more
wiley   +1 more source

\u3cem\u3eHelicobacter pylori\u3c/em\u3e infection in Havana, Cuba. Prevalence and \u3cem\u3ecagA\u3c/em\u3e status of the strains [PDF]

, 2005
There is a great paucity of information about Helicobacter pylori infection in the countries of the Caribbean basin. Almost no studies have been performed to determine the prevalence, antibiotic resistance or virulence factors of the bacterium.
Camou-Juncas, Christine, del Pilar Escobar, María, Díaz-Canel, Osvaldo, González, Nery, Gutiérrez, Beatriz, Leonard, Ibrahim, Martínez, Rolando, Mendz, George L, Mégraud, Françis, Paniagua, Manuel, Santos, Adriana, Valmaña, Carlos Ernesto, Vidal, Teresita   +12 more
core   +1 more source

METTL10‐Mediated PIAS3 Methylation Links Purine Metabolism to Gastric Cancer Progression

Advanced Science, EarlyView.
METTL10‐mediated methylation of PIAS3 at K442 inhibits its SUMO E3 ligase activity toward MITF. This reduces MITF SUMOylation and subsequent RNF4‐mediated ubiquitination, leading to MITF protein accumulation and gastric cancer progression. Abstract Metabolic dysregulation plays a significant role in the development of gastric cancer (GC).
Jinshui Tan, Huiwen Zhou, Jingsong Ma, Chensong Zhang, Yuhua Tan, Baoding Zhang, Jiabao Zhao, Ao Cheng, Chengyu Yang, Meijuan Xu, Shengyi Zhou, Yubo Xiong, Zeyang Lin, Guangchao Pan, Wenjie Ye, Mengya Zhong, Yang Yang, Yifan Zhuang, Shao‐Wei Li, Xianming Deng, Xuehui Hong   +20 more
wiley   +1 more source

Determinación de la presencia de Helicobacter spp. en perros, mediante biopsia gástrica obtenida por endoscopía

Revista Científica, 2010
Con el objeto de determinar la frecuencia de presentación de Helicobacter spp. se realizó un estudio en caninos de Valdivia, Chile, a través de biopsia gástrica de las zonas fúndica y pilórica obtenida por endoscopía y analizadas mediante las pruebas de
Julio Thibaut, Verónica Paz, Enrique Paredes, Santiago Ernst   +3 more
doaj  

Association Between Vitamin D Receptor Polymorphism and the Response to Helicobacter Pylori Treatment

Infection and Drug Resistance, 2023
Yousry Esam-Eldin Abo-Amer,1 Amal Ahmed Mohamed,2 Mohamed Mahmoud Elhoseeny,3 Samar M Rezk,4 Sherief Abdel-Salam,5 Abdulmohsen H Alrohaimi,6 Asmaa Sayed Abdelgeliel,7 Seham Saeed Alzahrani,8 Ibrahim Jafri,8 Leena S Alqahtani,9 Eman Fayad,8 Mohamed Fakhry,
Abo-Amer YEE, Mohamed AA, Elhoseeny MM, Rezk SM, Abdel-Salam S, Alrohaimi AH, Abdelgeliel AS, Alzahrani SS, Jafri I, Alqahtani LS, Fayad E, Fakhry M, Soliman MY   +12 more
doaj  

The Sole DEAD-Box RNA Helicase of the Gastric Pathogen Helicobacter pylori Is Essential for Colonization

mBio, 2018
Present in every kingdom of life, generally in multiple copies, DEAD-box RNA helicases are specialized enzymes that unwind RNA secondary structures. They play major roles in mRNA decay, ribosome biogenesis, and adaptation to cold temperatures.
Lamya El Mortaji, Sylvie Aubert, Eloïse Galtier, Christine Schmitt, Karine Anger, Yulia Redko, Yves Quentin, Hilde De Reuse   +7 more
doaj   +1 more source

Functional plasticity in the type IV secretion system of Helicobacter pylori. [PDF]

, 2012
Helicobacter pylori causes clinical disease primarily in those individuals infected with a strain that carries the cytotoxin associated gene pathogenicity island (cagPAI).
Barrozo, Roberto M, Cariaga, Taryn A, Cooke, Cara L, Cover, Timothy L, Gaddy, Jennifer A, Hansen, Lori M, Johnson, Elizabeth M, Lam, Anna M, Peek, Richard M, Solnick, Jay V, Suarez, Giovanni   +10 more
core   +1 more source

B‐EPIC: A Transformer‐Based Language Model for Decoding B Cell Immunodominance Patterns

Advanced Science, EarlyView.
B‐Epic: Achieving high‐accuracy B cell epitope prediction through Transformer architecture. Comprehensive validation demonstrates B‐Epic's robust performance across diverse datasets. B‐Epic facilitates vaccine development for H. pylori and EBV, addressing critical public health challenges.
Jun‐Ze Liang, Youtao Wang, Cong Sun, Tao Liu, Zengfeng Wu, Lipeng Chen, Lina Chen, Penglin Li, Zhengkang Li, Cangui Zhang, Bingyun Lu, Ye Chen, Bing Gu, Qian Zhong, Xin Wei Wang, Mu‐Sheng Zeng, Jinping Liu   +16 more
wiley   +1 more source