Results 41 to 50 of about 156,187 (258)

Exploring the mechanism of aloe-emodin in the treatment of liver cancer through network pharmacology and cell experiments

Frontiers in Pharmacology, 2023
Objective: Aloe-emodin (AE) is an anthraquinone compound extracted from the rhizome of the natural plant rhubarb. Initially, it was shown that AE exerts an anti-inflammatory effect. Further studies revealed its antitumor activity against various types of
Mingyang Zhu, Mingyang Zhu, Qingmin He, Yanan Wang, Yanan Wang, Liying Duan, Liying Duan, Kang Rong, Kang Rong, Yingying Wu, Yingying Wu, Ye Ding, Ye Ding, Yang Mi, Yang Mi, Yang Mi, Xiaoyang Ge, Xiaocui Yang, Yong Yu, Yong Yu   +19 more
doaj   +1 more source

Helicobacter pylori-induced histone modification, associated gene expression in gastric epithelial cells, and its implication in pathogenesis. [PDF]

, 2010
Histone modifications are critical in regulating gene expression, cell cycle, cell proliferation, and development. Relatively few studies have investigated whether Helicobacter pylori, the major cause of human gastric diseases, affects histone ...
Haas, Rainer, Rainer Haas, Grant, Patrick, Kaparakis-Liaskos, Maria, Hass, Rainer, Sheila E Crowe, Patrick A. Grant, Crowe, Sheila E., Crowe Sheila E., Liechti, George, Ferrero, Richard L., Richard L. Ferrero, D. Scott Merrell, Kaparakis-Liaskos Maria, Merrell, D. Scott, Wolfgang Fischer, Fischer, Wolfgang, Liechti George, Ferrero Richard L., Ding, Song-Ze, Goldberg Joanna B., Song-Ze Ding, Ding Song-Ze, George Liechti, Patrick A Grant, Crowe, Sheila, Goldberg, Joanna, Fischer Wolfgang, Joanna B Goldberg, D Scott Merrell, Hatakeyama, Masanori, Ferrero, Richard, Merrell D. Scott, Haas Rainer, Joanna B. Goldberg, Goldberg, Joanna B., Richard L Ferrero, Sheila E. Crowe, Masanori Hatakeyama, Grant Patrick A., Hatakeyama Masanori, Grant, Patrick A., Liaskos, Maria, Maria Kaparakis-Liaskos   +43 more
core   +1 more source

A dietary combination of red yeast rice, phytosterol ester and lycopene ameliorates hypercholesterolemia by regulating gut microbiota and activating hepatic FXR-LDLR/ABCG pathway in mice

Frontiers in Microbiology
BackgroundExcessive nutrition intake is a well-established contributor to obesity and hypercholesterolemia, both of which pose substantial risks to cardiovascular health.
Jingxian Xu, Jingxian Xu, Xin Huang, Xin Huang, Fei Pei, Yuzhu Chen, Yuzhu Chen, Cunzheng Zhang, Cunzheng Zhang, Lingling Zhao, Hua Zhang, Jindong Zhang, Jindong Zhang, Liping Duan, Liping Duan   +14 more
doaj   +1 more source

The HP0256 gene product is involved in motility and cell envelope architecture of Helicobacter pylori [PDF]

, 2010
Background Helicobacter pylori is the causative agent for gastritis, and peptic and duodenal ulcers. The bacterium displays 5-6 polar sheathed flagella that are essential for colonisation and persistence in the gastric mucosa.
Caly, Delphine L., O\u27Toole, Paul W., Penn Charles W, Stanley A Moore, Douillard, FP, Douillard, François P., Ryan, KA, Caly Delphine L, Hinds, Jason, Francois P Douillard, Charles W Penn, Moore, SA, Paul W O'Toole, Moore Stanley A, Lane, Michael C., Hinds Jason, Kieran A Ryan, Ryan Kieran A, Lane Michael C, Michael C Lane, Delphine C Caly, O'Toole Paul W, O'Toole, PW, Ryan, Kieran A., Penn, Charles, Caly, DL, Hinds, J, Penn, CW, Penn, Charles W., Jason Hinds, Lane, MC, Moore, Stanley A., Douillard François P, O'Toole, Paul W.   +33 more
core   +1 more source

Targeting the YAP‐BST2 Axis Overcomes Intrinsic Anti‐PD‐1 Resistance in Metastatic Gastric Cancer

Advanced Science, EarlyView.
Concurrent YAP hyperactivation and Tp53 loss in Atp4b‐expressed parietal cell lineage drives gastric cancer initiation, multi‐organ metastasis, and intrinsic resistance to anti‐PD‐1 therapy. BST2 emerges as a direct YAP‐TEAD transcriptional target that engages PIRA2 on myeloid cells to establish an immunosuppressive microenvironment.
Weihong Zhang, Shilong Wang, Meng Wang, Ruixian Yu, Jingwu Yue, Lin Shao, Hui Zhang, Mengwen Zhu, Luyang Tian, Shuting Cheng, Weimin Qin, Yang Tang, Yi Han, Wenjia Wang, Liwei An, Yan Meng, Shi Jiao, Zhaocai Zhou   +17 more
wiley   +1 more source

Helicobacter pylori cag-Pathogenicity island-dependent early immunological response triggers later precancerous gastric changes in Mongolian gerbils [PDF]

, 2009
Infection with Helicobacter pylori, carrying a functional cag type IV secretion system (cag-T4SS) to inject the Cytotoxin associated antigen (CagA) into gastric cells, is associated with an increased risk for severe gastric diseases in humans.
Haas, Rainer, Rainer Haas, Wiedemann, Tobias, Loell, Eva, Tobias Wiedemann, Eva Loell, Susanna Mueller, Stolte, Manfred, Stoeckelhuber, Mechthild, Rieder, Gabriele, Manfred Stolte, Gabriele Rieder, Mueller, Susanna, Mechthild Stoeckelhuber   +13 more
core   +2 more sources

An Adult Presentation of KIF11‐Related MCLID Syndrome: Case Report and 40‐Year Follow‐Up

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Pathogenic variants in KIF11 are linked to autosomal dominant syndromes with microcephaly, chorioretinopathy, lymphedema, and intellectual disability (MCLID), though adult presentations remain underreported. We report a 42‐year‐old female presenting with a de novo single‐amino acid in‐frame deletion in the KIF11 gene (c.1294_1296del; p ...
Thrishna Chathurvedula, Juvy Rabelas, Kareem Touleimat, Elaine Marchi, Ruhi Shah, Shaydah Kheradmand, Kuldeep Singh, Karen Amble, Gholson J. Lyon   +8 more
wiley   +1 more source

Simultaneous Detection of Caga and Cage of Helicobacter pylori Strains Recovered from Iranian Patients with Different Gastroduodenal Diseases

Iranian Journal of Public Health, 2009
Background: To asses the status of two representative genes of cag PAI i.e cagA and cagE of Helicobacter pylori strains infecting Iranian patients suffered from various clinical outcomes using one-step PCR. Methods: A total of 120 H.
M Douraghi , M Mohammadi , MH Shirazi, A Oghalaie , S Saberi Kashani , MA Mohagheghi, M Eshagh Hosseini , H Zeraati , M Esmaili , M Bababeik , N Mohajerani   +10 more
doaj  

An RGD helper sequence in CagL of Helicobacter pylori assists in interactions with integrins and injection of CagA [PDF]

, 2012
Conradi J, Tegtmeyer N, Wozna M, et al. An RGD helper sequence in CagL of Helicobacter pylori assists in interactions with integrins and injection of CagA. Frontiers in Cellular and Infection Microbiology.
Backert, Steffen, Tegtmeyer, Nicole, Timothy L Cover, Steffen Backert, Gagell, Corinna, Marta eWoźna, Marco eWissbrock, Cover, Timothy L., Sewald, Norbert ; https://orcid.org/, Michalek, Carmela, Frank, Ronald, Ronald eFrank, Norbert eSewald, Jens eConradi, Nicole Tegtmeyer, Carmela Michalek, Corinna eGagell, Jens Conradi, Steffen eBackert, Norbert Sewald, Carmela eMichalek, Marco Wissbrock, Wißbrock, Marco, Timothy L. Cover, Wozna, Marta, Marta Woźna, Corinna Gagell, Ronald Frank, Conradi, Jens, Nicole eTegtmeyer   +29 more
core   +1 more source

Reframing the Gut–Brain Axis: The Gut Wall as a Neural Immune Interface in Multiple Sclerosis and Autoimmune Neurological Diseases

Annals of Neurology, EarlyView.
Gut wall physiology in multiple sclerosis (MS) and autoimmune neurologic diseases remains underexplored but may span gut barrier dysfunction, enteric glial targeting, mucosal immune dysregulation, and autoimmune targets within the enteric nervous system (ENS).
Federico Montini, Sean J. Pittock, Laura Cacciaguerra, Howard L. Weiner, Luke A. Schwerdtfeger   +4 more
wiley   +1 more source