Results 41 to 50 of about 133,418 (255)

PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC

Advanced Science, EarlyView.
CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao, Qinyuan Liu, Zhongwei Xin, Zhiyao Zhou, Mingjie Lin, Di Chen, Zhixing Hao, Yongyuan Chen, Wenxuan Wu, Shuyang Zhang, Xiaoke Chen, Xia Xu, Jinfan Li, Wei Lin, Yuhao Lu, Dang Wu, Pin Wu   +16 more
wiley   +1 more source

Revealing the pathogenesis of gastric intestinal metaplasia based on the mucosoid air-liquid interface

Journal of Translational Medicine
Background Gastric intestinal metaplasia (GIM) is an essential precancerous lesion. Although the reversal of GIM is challenging, it potentially brings a state-to-art strategy for gastric cancer therapeutics (GC).
Simeng Liu, Huijuan Wen, Fazhan Li, Xia Xue, Xiangdong Sun, Fuhao Li, Ruoyu Hu, Huayuan Xi, Francesco Boccellato, Thomas F Meyer, Yang Mi, Pengyuan Zheng   +11 more
doaj   +1 more source

Helicobacter pylori infection status and evolution of gastric cancer

Chinese Medical Journal
. Gastric cancer (GC) is a globally prevalent malignancy with a particularly heavy burden in China. Helicobacter pylori (H. pylori) is a Group I carcinogen for GC, with a higher seroprevalence rate indicating a higher GC incidence.
Wenlin Zhang, Yuxin Zhang, Jing Ning, Weiwei Fu, Shigang Ding, Yuanyuan Ji   +5 more
doaj   +1 more source

Gemella morbillorum Promotes Colorectal Carcinogenesis: LPBDCP‐Mediated Invasion Activates Ras Signaling and Destabilizes p53

Advanced Science, EarlyView.
ABSTRACT Gut microbiota dysbiosis promotes colorectal cancer (CRC) tumorigenesis. A global fecal metagenomic analysis identified Gemella morbillorum as a key contributor to the CRC‐associated microbiota. Fluorescence in situ hybridization revealed that Gemella morbillorum is enriched in CRC tumor tissues compared to adjacent normal tissues.
Zhen Wang, Jia Zhang, Haojie Lu, Jingjing Ni, Shuaishuai Yang, Yuting Shi, Shuo Zhang, Pei Zhang, Li Liu   +8 more
wiley   +1 more source

Impact of Maternal Helicobacter pylori Infection on Trace Elements (Copper, Iron and Zinc) and Pregnancy Outcomes [PDF]

, 2010
Background: H. pylori infection has been suggested to interfere with micronutrient metabolism and influence pregnancy outcomes. Objectives: This study therefore seeks to document the prevalence of H.
Akubugwo, EI, Ugwuja, EI
core  

Is Helicobacter Pylori Associated with a Migraine? [PDF]

, 2017
Objective: To determine whether Helicobacter pylori (H. pylori) is associated with migraine headache. Design: Case-control study. Settings: Local tertiary Hospitals in Cairo, Egypt and in HaferAlbaten, Saudi Arabia.
Ali Radwa A, Mahmoud Mohamed A, Ali Abdelrazak M   +2 more
core   +1 more source

Single-cell RNA profiling of colorectal granular-type laterally spreading tumor uncovers progression trajectory toward carcinoma and transcriptional signatures favoring lateral morphogenesis

Frontiers in Oncology
BackgroundColorectal laterally spreading tumors (LSTs) are defined as non-protruding neoplasms exceeding 10 mm in diameter that grow primarily along the intestinal wall.
Yueqing Gong, Yueqing Gong, Yuxin Zhang, Yuxin Zhang, Xun Liu, Xun Liu, Rongli Cui, Rongli Cui, Jingjing Lu, Jingjing Lu, Jun Li, Jun Li, Fang Gu, Fang Gu, Jing Zhang, Jing Zhang, Shigang Ding, Shigang Ding, Weiwei Fu, Weiwei Fu   +19 more
doaj   +1 more source

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

Seroprevalence of anti-Hp and anti-cagA antibodies among healthy persons in Golestan province, northeast of Iran (2010) [PDF]

, 2011
Background: The major cause of peptic ulcer disease is helicobacter pylori (Hp), and it is also implicated in the pathogenesis of adenocarcinoma of the distal stomach and gastric lymphoma.
Bagheri, H., Ghaemi, E., Kebria, F.G., Semnani, S.   +3 more
core   +1 more source

Polarised epithelial monolayers of the gastric mucosa reveal insights into mucosal homeostasis and defence against infection [PDF]

, 2018
Objective Helicobacter pylori causes life-long colonisation of the gastric mucosa, leading to chronic inflammation with increased risk of gastric cancer.
Berger, H., Boccellato, F., Denecke, C., Goosmann, C., Imai-Matsushima, A., Meyer, T., Morey, P., Ordemann, J., Sanchez, G., Schmid, M., Woelffling, S.   +10 more
core   +3 more sources