Results 31 to 40 of about 133,418 (255)

Exploring the mechanism of curcumin in the treatment of colon cancer based on network pharmacology and molecular docking

Frontiers in Pharmacology, 2023
Objective: Curcumin is a plant polyphenol extracted from the Chinese herb turmeric. It was found that curcumin has good anti-cancer properties in a variety of cancers, but the exact mechanism is not clear.
Qingmin He, Qingmin He, Chuan Liu, Xiaohan Wang, Xiaohan Wang, Kang Rong, Kang Rong, Mingyang Zhu, Mingyang Zhu, Liying Duan, Liying Duan, Pengyuan Zheng, Pengyuan Zheng, Pengyuan Zheng, Yang Mi, Yang Mi, Yang Mi   +16 more
doaj   +1 more source

Treatment of helicobacter pylori infection in atrophic gastritis [PDF]

, 2018
Helicobacter pylori (Hp) is a major human pathogen causing chronic, progressive gastric mucosal damage and is linked to gastric atrophy and cancer. Hp-positive individuals constitute the major reservoir for transmission of infection.
Annibale, B, Carabotti, M, Lahner, E
core   +1 more source

Comparison of omeprazole, metronidazole and clarithromycin with omeprazole/amoxicillin dual-therapy for the cure of Helicobacter pylori infection [PDF]

, 1998
In this randomized, multicenter trial, we evaluated the effectiveness and side effect profile of a modified omeprazole-based triple therapy to cure Helicobacter pylori infection.
Bayerdörffer, Ekkehard, Bolle, Karl-Heinz, Höchter, Wilhelm, Klann, Hermann, Krämer, Walter, Lehn, Norbert, Meining, Alexander, Miehlke, Stephan, Simon, Thomas, Sommer, Albrecht, Stolte, Manfred, Weingart, Josef   +11 more
core   +1 more source

Serum proteomic profiling of precancerous gastric lesions and early gastric cancer reveals signatures associated with systemic inflammatory response and metaplastic differentiation

Frontiers in Molecular Biosciences
The noninvasive detection technique using serum for large-scale screening is useful for the early diagnosis of gastric cancer (GC). Herein, we employed liquid chromatography mass spectrometry to determine the serum proteome signatures and related ...
Yueqing Gong, Yueqing Gong, Yaxin Lou, Xiurui Han, Xiurui Han, Keyan Chen, Keyan Chen, Yang Zhao, Hejun Zhang, Hejun Zhang, Jing Zhang, Jing Zhang, Ying Xiong, Ying Xiong, Weiwei Fu, Weiwei Fu, Shigang Ding, Shigang Ding   +17 more
doaj   +1 more source

Recent acquisition of Helicobacter pylori by Baka Pygmies [PDF]

, 2013
Both anatomically modern humans and the gastric pathogen Helicobacter pylori originated in Africa, and both species have been associated for at least 100,000 years. Seven geographically distinct H.
AB Migliano, Armand Nkwescheu, Ayas Maady, B Linz, B Pakendorf, Bodo Linz, C Batini, C Ehret, CM Schlebusch, CY Tay, D Falush, D Falush, D Schoenbrun, Daniel Eibach, Daniel Falush, DD Palmer, DM Behar, DM Magalhaes Queiroz, DY Graham, E Patin, G Brusotti, G Hellenthal, G Jobb, G Morelli, Gil McVean, JC Assob, JG Kusters, Jose Siri, JZ Li, KA Jolley, L Excoffier, L Naduvilezhath, L Quintana-Murci, LA Zhivotovsky, M Achtman, M Guisset, M Jakobsson, M Kawai, Mark Achtman, MC Campbell, MF Rupnow, MF Rupnow, MF Rupnow, MJ Hamilton, MK Gonder, NA Drake, NA Rosenberg, NS Becker, P Librado, RE Pounder, RN Ndip, RN Ndip, RR Hudson, RR Hudson, RW Frenck Jr, S Breurec, S Latifi-Navid, S Schwarz, SA Tishkoff, Sandra Nell, SC Schuster, Sebastian Suerbaum, T Wirth, TH Farag, V Kuete, V Montano, Valeria Montano, W Delport, Wael F. Elamin, X Didelot, Y Chen, Y Moodley, Y Moodley, Yoshan Moodley   +73 more
core   +3 more sources

Functional plasticity in the type IV secretion system of Helicobacter pylori. [PDF]

, 2012
Helicobacter pylori causes clinical disease primarily in those individuals infected with a strain that carries the cytotoxin associated gene pathogenicity island (cagPAI).
Barrozo, Roberto M, Cariaga, Taryn A, Cooke, Cara L, Cover, Timothy L, Gaddy, Jennifer A, Hansen, Lori M, Johnson, Elizabeth M, Lam, Anna M, Peek, Richard M, Solnick, Jay V, Suarez, Giovanni   +10 more
core   +1 more source

The association of CagA EPIYA motifs and vacA genotypes with homologous recombination repair markers during the gastric precancerous cascade

The International Journal of Biological Markers, 2020
Background: Helicobacter pylori -induced DNA damage and impaired homologous recombination repair are vital molecular mechanisms for gastric cancer, which mainly count on its virulence factors cytotoxic-associated gene A (CagA) and vacuolating cytotoxin A
Yang Mi, Haibin Dong, Xiangdong Sun, Feifei Ren, Youcai Tang, Pengyuan Zheng   +5 more
doaj   +1 more source

Exploring the mechanism of aloe-emodin in the treatment of liver cancer through network pharmacology and cell experiments

Frontiers in Pharmacology, 2023
Objective: Aloe-emodin (AE) is an anthraquinone compound extracted from the rhizome of the natural plant rhubarb. Initially, it was shown that AE exerts an anti-inflammatory effect. Further studies revealed its antitumor activity against various types of
Mingyang Zhu, Mingyang Zhu, Qingmin He, Yanan Wang, Yanan Wang, Liying Duan, Liying Duan, Kang Rong, Kang Rong, Yingying Wu, Yingying Wu, Ye Ding, Ye Ding, Yang Mi, Yang Mi, Yang Mi, Xiaoyang Ge, Xiaocui Yang, Yong Yu, Yong Yu   +19 more
doaj   +1 more source

Bacteria‐Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy

Advanced Materials, EarlyView.
Bacteria‐responsive nanocarriers are designed to release antimicrobials only in the presence of infection‐specific cues. This selective activation ensures drug release precisely at the site of infection, avoiding premature or indiscriminate release, and enhancing efficacy.
Guillermo Landa, Gracia Mendoza, Silvia Irusta, Manuel Arruebo   +3 more
wiley   +1 more source

Effect of native gastric mucus on in vivo hybridization therapies directed at Helicobacter pylori [PDF]

, 2015
Helicobacter pylori infects more than 50% of the worldwide population. It is mostly found deep in the gastric mucus lining of the stomach, being a major cause of peptic ulcers and gastric adenocarcinoma. To face the increasing resistance of H.
Azevedo, Nuno F, Braeckmans, Kevin, Dakwar, George, De Smedt, Stefaan, Figueiredo, Céu, Fontenete, Silvia, Forier, Katrien, Guimarães, Nuno, Leite, Marina, Remaut, Katrien, Santos, Rita, Stremersch, Stephan, Wengel, Jesper, Xiong, Ranhua   +13 more
core   +6 more sources