Results 21 to 30 of about 89,054 (257)

Chimeric RNA-binding protein-based killing switch targeting hepatocellular carcinoma cells

Molecular Therapy: Nucleic Acids, 2021
Cancer cell-specific killing switches are synthetic circuits developed as an intelligent weapon to specifically eliminate malignant cells. RNA-delivered synthetic circuits provide safer means to control oncolytic functions, in which proteolysis ...
Jiong Yang, Shigang Ding
doaj   +1 more source

The association of CagA EPIYA motifs and vacA genotypes with homologous recombination repair markers during the gastric precancerous cascade

The International Journal of Biological Markers, 2020
Background: Helicobacter pylori -induced DNA damage and impaired homologous recombination repair are vital molecular mechanisms for gastric cancer, which mainly count on its virulence factors cytotoxic-associated gene A (CagA) and vacuolating cytotoxin A
Yang Mi, Haibin Dong, Xiangdong Sun, Feifei Ren, Youcai Tang, Pengyuan Zheng   +5 more
doaj   +1 more source

Serum proteomic profiling of precancerous gastric lesions and early gastric cancer reveals signatures associated with systemic inflammatory response and metaplastic differentiation

Frontiers in Molecular Biosciences
The noninvasive detection technique using serum for large-scale screening is useful for the early diagnosis of gastric cancer (GC). Herein, we employed liquid chromatography mass spectrometry to determine the serum proteome signatures and related ...
Yueqing Gong, Yueqing Gong, Yaxin Lou, Xiurui Han, Xiurui Han, Keyan Chen, Keyan Chen, Yang Zhao, Hejun Zhang, Hejun Zhang, Jing Zhang, Jing Zhang, Ying Xiong, Ying Xiong, Weiwei Fu, Weiwei Fu, Shigang Ding, Shigang Ding   +17 more
doaj   +1 more source

Bacteria‐Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy

Advanced Materials, EarlyView.
Bacteria‐responsive nanocarriers are designed to release antimicrobials only in the presence of infection‐specific cues. This selective activation ensures drug release precisely at the site of infection, avoiding premature or indiscriminate release, and enhancing efficacy.
Guillermo Landa, Gracia Mendoza, Silvia Irusta, Manuel Arruebo   +3 more
wiley   +1 more source

Exploring the mechanism of aloe-emodin in the treatment of liver cancer through network pharmacology and cell experiments

Frontiers in Pharmacology, 2023
Objective: Aloe-emodin (AE) is an anthraquinone compound extracted from the rhizome of the natural plant rhubarb. Initially, it was shown that AE exerts an anti-inflammatory effect. Further studies revealed its antitumor activity against various types of
Mingyang Zhu, Mingyang Zhu, Qingmin He, Yanan Wang, Yanan Wang, Liying Duan, Liying Duan, Kang Rong, Kang Rong, Yingying Wu, Yingying Wu, Ye Ding, Ye Ding, Yang Mi, Yang Mi, Yang Mi, Xiaoyang Ge, Xiaocui Yang, Yong Yu, Yong Yu   +19 more
doaj   +1 more source

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

Revealing the pathogenesis of gastric intestinal metaplasia based on the mucosoid air-liquid interface

Journal of Translational Medicine
Background Gastric intestinal metaplasia (GIM) is an essential precancerous lesion. Although the reversal of GIM is challenging, it potentially brings a state-to-art strategy for gastric cancer therapeutics (GC).
Simeng Liu, Huijuan Wen, Fazhan Li, Xia Xue, Xiangdong Sun, Fuhao Li, Ruoyu Hu, Huayuan Xi, Francesco Boccellato, Thomas F Meyer, Yang Mi, Pengyuan Zheng   +11 more
doaj   +1 more source

Helicobacter pylori infection status and evolution of gastric cancer

Chinese Medical Journal
. Gastric cancer (GC) is a globally prevalent malignancy with a particularly heavy burden in China. Helicobacter pylori (H. pylori) is a Group I carcinogen for GC, with a higher seroprevalence rate indicating a higher GC incidence.
Wenlin Zhang, Yuxin Zhang, Jing Ning, Weiwei Fu, Shigang Ding, Yuanyuan Ji   +5 more
doaj   +1 more source

Multi‐Targeting Carnosic Acid Kills Drug‐Resistant Helicobacter pylori With Narrow‐Spectrum Activity

Advanced Science, EarlyView.
Carnosic acid selectively eradicates drug‐resistant Helicobacter pylori through a multi‐targeted mechanism involving urease inhibition, membrane disruption, and biofilm eradication. It exhibits no detectable resistance, potent in vivo efficacy, and minimal impact on gut microbiota, positioning it as a promising narrow‐spectrum lead compound against ...
Yuefan Bai, Hongming Huang, Xudong Hang, Shanwei Hu, Qian Tong, Jingchen Xu, Jia Jia, Hongkai Bi   +7 more
wiley   +1 more source

Upstream stimulating factor 1 (USF1) -202 G/A polymorphism and serum levels of USF1 and USF2 are associated with gastric cancer risk: a case control study

Journal of Cancer Research and Clinical Oncology
Purpose Gastric cancer is an inflammation-driven disease often associated with a bad prognosis. Upstream stimulatory factors USF1 and USF2 are pleiotropic transcription factors, with tumor suppressor function.
Ghizlane Bounder, Mohamed Reda Jouimyi, Imane Essaidi, Ilhame Elyounsi, Hasna Boura, Valérie Michel, Wafa Badre, Eliette Touati, Fatima Maachi   +8 more
doaj   +1 more source