Results 61 to 70 of about 276,829 (341)

RELA Ablation Contributes to Progression of Hepatocellular Carcinoma with TP53R249S Mutation and is a Potential Therapeutic Target

Advanced Science, EarlyView.
Genome‐wide CRISPR/Cas9 based screening identified RELA as a key tumor suppressor in TP53R249S‐mutant HCC. Its loss promotes tumorigenesis and metastasis via DVL1‐mediated Wnt/β‐catenin activation, while its agonist betulinic acid suppresses tumor progression.
Zhiping Wu, Zhe Wang, Diwei Zheng, Yongfang Zheng, Zhiwu Jiang, Jiang Lv, Yueqin Zhu, Heng Jia, Ziyuan Duan, Tingjie Yuan, Qiting Wu, Youguo Long, Shouheng Lin, Yao Yao, Georgia Carson, Jean P. Thiery, Kwan Man, Peng Li   +17 more
wiley   +1 more source

Simultaneous Detection of Caga and Cage of Helicobacter pylori Strains Recovered from Iranian Patients with Different Gastroduodenal Diseases

Iranian Journal of Public Health, 2009
Background: To asses the status of two representative genes of cag PAI i.e cagA and cagE of Helicobacter pylori strains infecting Iranian patients suffered from various clinical outcomes using one-step PCR. Methods: A total of 120 H.
M Douraghi , M Mohammadi , MH Shirazi, A Oghalaie , S Saberi Kashani , MA Mohagheghi, M Eshagh Hosseini , H Zeraati , M Esmaili , M Bababeik , N Mohajerani   +10 more
doaj  

CagA-specific Gastric CD8+ Tissue-Resident T Cells Control Helicobacter pylori During the Early Infection Phase [PDF]

, 2022
Maximilian R. Koch, Ruolan Gong, Verena Friedrich, Veronika Engelsberger, Lorenz Kretschmer, Andreas Wanisch, Sebastian Jarosch, Anna Ralser, Bob Lugen, Michael Quante, Michael Vieth, Riccardo Vasapolli, Christian Schulz, Veit R. Buchholz, Dirk H. Busch, Raquel Mejías‐Luque, Markus Gerhard   +16 more
openalex   +1 more source

B‐EPIC: A Transformer‐Based Language Model for Decoding B Cell Immunodominance Patterns

Advanced Science, EarlyView.
B‐Epic: Achieving high‐accuracy B cell epitope prediction through Transformer architecture. Comprehensive validation demonstrates B‐Epic's robust performance across diverse datasets. B‐Epic facilitates vaccine development for H. pylori and EBV, addressing critical public health challenges.
Jun‐Ze Liang, Youtao Wang, Cong Sun, Tao Liu, Zengfeng Wu, Lipeng Chen, Lina Chen, Penglin Li, Zhengkang Li, Cangui Zhang, Bingyun Lu, Ye Chen, Bing Gu, Qian Zhong, Xin Wei Wang, Mu‐Sheng Zeng, Jinping Liu   +16 more
wiley   +1 more source

Revealing the role of metformin in gastric intestinal metaplasia treatment

Frontiers in Pharmacology
ObjectiveGastric intestinal metaplasia (IM) is a precancerous stage associated with gastric cancer. Despite the observed beneficial effects of metformin on IM, its molecular mechanism remains not fully elucidated.
Ruoyu Hu, Ruoyu Hu, Xia Xue, Xiangdong Sun, Yang Mi, Huijuan Wen, Huijuan Wen, Huayuan Xi, Huayuan Xi, Fuhao Li, Fuhao Li, Pengyuan Zheng, Pengyuan Zheng, Simeng Liu, Simeng Liu   +14 more
doaj   +1 more source

The effect of microRNA-375 overexpression, an inhibitor of Helicobacter pylori-induced carcinogenesis, on lncRNA SOX2OT [PDF]

, 2016
Background: Helicobacter pylori is a major human pathogenic bacterium in gastric mucosa. Although the association between gastric cancer and H. pylori has been well-established, the molecular mechanisms underlying H.
Aleyasin, S.A., Mowla, S.J., Shafiee, M., Vasei, M., Yazdanparast, S.A.   +4 more
core   +1 more source

Balanced Expression of the Diiron Oxygenase BioE Is Essential for Biotin Homeostasis in Elizabethkingia meningoseptica

Advanced Science, EarlyView.
BioE is a new diiron oxygenase that catalyzes the conversion of long‐chain acyl groups into pimeloyl thioester, initiating biotin synthesis. The overexpression of EmBioE disrupts lipid metabolic homeostasis, requiring repressor BioL to maintain a balance between long‐chain fatty acids and biotin synthesis.
Meng Zhang, Ying‐ying Fu, Xiaoqiang Yang, Qiuying Qin, Xinyu Su, Jiaming Fang, Yanhua Kang, Qingwen He, Zhi Ruan, Yongchang Xu   +9 more
wiley   +1 more source

Identifying the signature of NAD+ metabolism-related genes for immunotherapy of gastric cancer

Heliyon
NAD (Nicotinamide Adenine Dinucleotide) -related metabolic reprogramming in tumor cells involves multiple vital cellular processes. However, the role of NAD metabolism in immunity and the prognosis of gastric cancer (GC) remains not elucidated.
Huijuan Wen, Yang Mi, Fazhan Li, Xia Xue, Xiangdong Sun, Pengyuan Zheng, Simeng Liu   +6 more
doaj   +1 more source

Dental Biofilm, a reservoir for Helicobacter Pylori in patients with chronic gastritis

Revista de la Facultad de Medicina Humana, 2020
Objectives: To determine the prevalence of helicobacter pylori in dental biofilm in patients with chronic gastritis in the gastroenterology service of Hospital María Helper.
Israel Armando Guerra Cuyutupac
doaj   +1 more source

\u3cem\u3eHelicobacter pylori\u3c/em\u3e infection in Havana, Cuba. Prevalence and \u3cem\u3ecagA\u3c/em\u3e status of the strains [PDF]

, 2005
There is a great paucity of information about Helicobacter pylori infection in the countries of the Caribbean basin. Almost no studies have been performed to determine the prevalence, antibiotic resistance or virulence factors of the bacterium.
Camou-Juncas, Christine, del Pilar Escobar, María, Díaz-Canel, Osvaldo, González, Nery, Gutiérrez, Beatriz, Leonard, Ibrahim, Martínez, Rolando, Mendz, George L, Mégraud, Françis, Paniagua, Manuel, Santos, Adriana, Valmaña, Carlos Ernesto, Vidal, Teresita   +12 more
core   +1 more source