Identification, characterization, and expression profiling of the bHLH gene family in Beta vulgaris [PDF]
BMC Plant BiologyBackground Basic helix-loop-helix (bHLH) is one of the largest families of transcription factors in plants, animals, and microorganisms and plays important complex physiological role in plant growth and development, metabolic regulation, and ...
Haizhu Yang +8 more
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A generalized allosteric mechanism for cis-regulated cyclic nucleotide binding domains. [PDF]
PLoS Computational Biology, 2008 Cyclic nucleotides (cAMP and cGMP) regulate multiple intracellular processes and are thus of a great general interest for molecular and structural biologists.
Alexandr P Kornev +2 more
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MD investigation on the binding of microphthalmia-associated transcription factor with DNA
Journal of Saudi Chemical Society, 2022 As a main regulator of melanocyte development and an key melanoma oncogene, microphthalmia-associated transcription factor (MITF) is one of the proteins in the basic helix-loop-helix zipper (bHLHZip) transcription factor family. The study on the detailed
Xiang-Feng Wang +6 more
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Conformational preference of 'CαNN' short peptide motif towards recognition of anions. [PDF]
PLoS ONE, 2013 Among several 'anion binding motifs', the recently described 'C(α)NN' motif occurring in the loop regions preceding a helix, is conserved through evolution both in sequence and its conformation. To establish the significance of the conserved sequence and
Tridip Sheet +2 more
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The MX-Helix of Muscle nAChR Subunits Regulates Receptor Assembly and Surface Trafficking
Frontiers in Molecular Neuroscience, 2020 Nicotinic acetylcholine receptors (AChRs) are pentameric channels that mediate fast transmission at the neuromuscular junction (NMJ) and defects in receptor expression underlie neuromuscular disorders such as myasthenia gravis and congenital myasthenic ...
Jolene Chang Rudell +4 more
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Combinatorial action of Grainyhead, Extradenticle and Notch in regulating Hox mediated apoptosis in Drosophila larval CNS. [PDF]
PLoS Genetics, 2017 Hox mediated neuroblast apoptosis is a prevalent way to pattern larval central nervous system (CNS) by different Hox genes, but the mechanism of this apoptosis is not understood.
Risha Khandelwal +4 more
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Structural variation and uniformity among tetraloop-receptor interactions and other loop-helix interactions in RNA crystal structures. [PDF]
PLoS ONE, 2012 Tetraloop-receptor interactions are prevalent structural units in RNAs, and include the GAAA/11-nt and GNRA-minor groove interactions. In this study, we have compiled a set of 78 nonredundant loop-helix interactions from X-ray crystal structures, and ...
Li Wu +3 more
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Scientific Reports, 2021 Genome-wide association studies (GWAS) have identified multiple genetic risk signals for Parkinson’s disease (PD), however translation into underlying biological mechanisms remains scarce.
Victoria Berge-Seidl +2 more
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Phosphopeptide mapping of proteins ectopically expressed in tissue culture cell lines
Biological Procedures Online, 2004 Post-translational modifications such as phosphorylation play a vital role in the regulation of protein function. In our study of the basic Helix-loop-Helix (bHLH) transcription factor HAND1, it was suspected that HAND1 was being phosphorylated during ...
Firulli Beth A. +2 more
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Amyloid Assembly Endows Gad m 1 with Biomineralization Properties
Biomolecules, 2018 Acid proteins capable of nucleating Ca2+ and displaying aggregation capacity play key roles in the formation of calcium carbonate biominerals. The helix-loop helix EF-hands are the most common Ca2+-binding motifs in proteins. Calcium is bound by the loop
Milagros Castellanos +3 more
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