Results 1 to 10 of about 845,626 (266)
Genome Wide Methylome Alterations in Lung Cancer. [PDF]
PLoS ONE, 2015 Aberrant cytosine 5-methylation underlies many deregulated elements of cancer. Among paired non-small cell lung cancers (NSCLC), we sought to profile DNA 5-methyl-cytosine features which may underlie genome-wide deregulation.
Nandita Mullapudi +12 more
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Myopia genetics in genome-wide association and post-genome-wide association study era [PDF]
International Journal of Ophthalmology, 2019 Genome-wide association studies (GWAS) of myopia and refractive error have generated exciting results and identified novel risk-associated loci. However, the interpretation of the findings of GWAS of complex diseases is not straightforward and has ...
Xuan Liao, Qing-Qing Tan, Chang-Jun Lan
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Genome wide study of tardive dyskinesia in schizophrenia
Translational Psychiatry, 2021 Tardive dyskinesia (TD) is a severe condition characterized by repetitive involuntary movement of orofacial regions and extremities. Patients treated with antipsychotics typically present with TD symptomatology.
Keane Lim +13 more
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Genome-wide studies of telomere biology in budding yeast
Microbial Cell, 2014 Telomeres are specialized DNA-protein structures at the ends of eukaryotic chromosomes. Telomeres are essential for chromosomal stability and integrity, as they prevent chromosome ends from being recognized as double strand breaks.
Yaniv Harari, Martin Kupiec
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Creating a RAW264.7 CRISPR-Cas9 Genome Wide Library
Bio-Protocol, 2017 The bacterial clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 genome editing tools are used in mammalian cells to knock-out specific genes of interest to elucidate gene function.
Brooke Napier , Denise Monack
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Evolutionary Applications, 2020 The three mussel species comprising the Mytilus complex are widespread across Europe and readily hybridize when they occur in sympatry, resulting in a mosaic of populations with varying genomic backgrounds. Two of these species, M.
David L. J. Vendrami +4 more
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Enhancing the genome editing toolbox: genome wide CRISPR arrayed libraries
Scientific Reports, 2017 CRISPR-Cas9 technology has accelerated biological research becoming routine for many laboratories. It is rapidly replacing conventional gene editing techniques and has high utility for both genome-wide and gene-focussed applications.
Emmanouil Metzakopian +14 more
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Genome wide analysis of
BMC Genomics, 2005 Background Core promoters are the gene regulatory regions most proximal to the transcription start site (TSS), central to the formation of pre-initiation complexes and for combinatorial gene regulation.
Molina Carlos, Grotewold Erich
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A concise history of genome-wide association studies
Saudi Journal of Medicine and Medical Sciences, 2013 Genome-wide association studies (GWASs) have had a tremendous impact on the pace of genomic research of common diseases. The number of identified genetic variants associated has grown exponentially. For some diseases, such as coronary heart disease (CHD),
Bobby P. C. Koeleman +3 more
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Unbiased population heterozygosity estimates from genome‐wide sequence data
Methods in Ecology and Evolution, 2021 Heterozygosity is a metric of genetic variability frequently used to inform the management of threatened taxa. Estimating observed and expected heterozygosities from genome‐wide sequence data has become increasingly common, and these estimates are often ...
Thomas L. Schmidt +3 more
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