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Genome-Wide Variation in Potyviruses [PDF]
Frontiers in Plant Science, 2019 Potyviruses (family Potyviridae, genus Potyvirus) are the result of an initial radiation event that occurred 6,600 years ago. The genus currently consists of 167 species that infect monocots or dicots, including domesticated and wild plants.
Deepti Nigam +3 more
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The future is genome-wide [PDF]
Genome Biology, 2006 A report of the annual meeting of the European Society of Human Genetics, Amsterdam, 6-9 May 2006.
Deutsch, S., Reymond, A.
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Journal of Investigative Dermatology, 2013 WhaT is epiGeneTics? The term “epigenetics” was coined by Conrad Waddington to describe “the branch of biology which studies the causal interactions between genes and their products, which bring the phenotype into being” (Goldberg et al., 2007). Very broadly, the word has come to refer to the study of the regulation of genes, their expression, and how ...
Capell, Brian C., Berger, Shelley L.
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Genome-wide approaches to schizophrenia [PDF]
Brain Research Bulletin, 2010 Schizophrenia (SZ) is a common and severe psychiatric disorder with both environmental and genetic risk factors, and a high heritability. After over 20 years of molecular genetics research, new molecular strategies, primarily genome-wide association studies (GWAS), have generated major tangible progress.
Jubao, Duan +2 more
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Genome-Wide Variation in Betacoronaviruses
Journal of Virology, 2021 Natural infection with SARS-CoV-2 and vaccines triggers the formation of antibodies against the S glycoprotein, which are detected by antibody-based diagnostic tests. Our analysis showed that variation in the S glycoprotein is a general feature of all species in the genus Betacoronavirus , including three species ...
Katherine LaTourrette +4 more
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Genome-wide somatic hypermutation [PDF]
Proceedings of the National Academy of Sciences, 2004 DNA mutagenesis is generally considered harmful. Yet activated B cells normally mutate the Ig loci. Because this somatic hypermutation is potentially dangerous, it has been hypothesized that mutations do not occur throughout the genome but instead are actively targeted to the Ig loci.
Clifford L, Wang +2 more
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Genome-wide analysis of insomnia disorder [PDF]
Molecular Psychiatry, 2018 Insomnia is a worldwide problem with substantial deleterious health effects. Twin studies have shown a heritable basis for various sleep-related traits, including insomnia, but robust genetic risk variants have just recently begun to be identified. We conducted genome-wide association studies (GWAS) of soldiers in the Army Study To Assess Risk and ...
Murray B. Stein +13 more
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INFERRING GENOME-WIDE MOSAIC STRUCTURE [PDF]
Biocomputing 2009, 2008 Genetic recombination plays two essential biological roles. It ensures the fidelity of the transmission of genetic information from one generation to the next and it generates new combinations of genetic variants. Therefore, recombination is a critical process in shaping arrangement of polymorphisms within populations.
Qi Zhang 0025 +4 more
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Genome-wide Association Studies
, 2013 Genome-wide association studies (GWAS) are a powerful hypothesis-free tool for the dissection of susceptibility to common heritable human diseases, including osteoporosis. To date, more than 2000 loci for common human diseases have been identified by GWAS.
Duncan, Emma, Brown, Matthew
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A genome‐wide investigation of food addiction [PDF]
Obesity, 2016 ObjectiveEvidence of parallels between drug addiction and eating behavior continues to accumulate. Genetic studies of addictive substances have yielded a number of susceptibility loci that point to common higher order genetic pathways underlying addiction.
Cornelis, Marilyn +6 more
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