Results 11 to 20 of about 3,210,341 (315)

Genome-wide studies of telomere biology in budding yeast

Microbial Cell, 2014
Telomeres are specialized DNA-protein structures at the ends of eukaryotic chromosomes. Telomeres are essential for chromosomal stability and integrity, as they prevent chromosome ends from being recognized as double strand breaks.
Yaniv Harari, Martin Kupiec
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Genome-wide analysis reveals extensive functional interaction between DNA replication initiation and transcription in the genome of trypanosoma brucei [PDF]

, 2012
Identification of replication initiation sites, termed origins, is a crucial step in understanding genome transmission in any organism. Transcription of the Trypanosoma brucei genome is highly unusual, with each chromosome comprising a few discrete ...
Dickens, N.J., Dickens, N, Kelly, S, Marcello, Lucio, Swiderski, M, Stephen D. Bell, Farr, Helen, Farr, H., Swiderski, M., Vaughan, D., Diane Vaughan, Bell, Stephen D, Nicholas Dickens, Marcello, L., Steven Kelly, Tiengwe, C, Dickens, Nicholas, Marcello, L, Bell, SD, Bell, Stephen D., Vaughan, D, McCulloch, R, Kelly, S., Swiderski, Michal, Keith Gull, Tiengwe, Calvin, Barry, J.D., McCulloch, R., Barry, J David, Barry, JD, Farr, H, Gull, K, Lucio Marcello, Richard McCulloch, J. David Barry, Bell, S.D., Calvin Tiengwe, McCulloch, Richard, Kelly, Steven, Helen Farr, Tiengwe, C., Gull, Keith, Barry, J. David, Vaughan, Diane, Gull, K., Michal Swiderski   +45 more
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Genome-wide association study of major depressive disorder: new results, meta-analysis, and lessons learned [PDF]

, 2010
Major depressive disorder (MDD) is a common complex disorder with a partly genetic etiology. We conducted a genome-wide association study of the MDD2000+ sample (2431 cases, 3673 screened controls and >1 M imputed single-nucleotide polymorphisms (SNPs)).
D I Boomsma, Maclean, A. W., Sullivan, P.F., Sullivan, P F, G Willemsen, de Geus, E.J.C., D J Statham, Willemsen, G.; id_orcid, Gordon, SD, Penninx, BWJH, Smit, J H, Medland, S E, Maclean, A.W., S E Medland, Penninx, B. W. J. H., van den Oord, E J C G, Montgomery, G W, Pergadia, M L, Byrne, E.M., Heath, A.C., Martin, N.G., MacIntyre, Donald; id_orcid, Hickie, I.B., Statham, D.J., C M Middeldorp, E M Byrne, B W J H Penninx, Nyholt, D.R., J J Hottenga, J H Smit, A K Henders, Blackwood, D.H., Liu, J. Z., N G Martin, A W Maclean, Lewis, C.M., Montgomery, G. W., McGuffin, P, S D Gordon, McEvoy, B.P., MacIntyre, D J, McGhee, K A, P A F Madden, MacIntyre, D J; id_orcid, Pergadia, M. L., van den Oord, E.J., McEvoy, B P, Gordon, S.D., Martin, N. G., D H R Blackwood, P F Sullivan, De Geus, E. J. C., Montgomery, G.W., Hottenga, J.J., Hickie, I. B., McGhee, K.A., Medland, S. E., C M Lewis, J Z Liu, Gordon, S D, Smit, J. H., Boomsma, D. I., Hottenga, J. J., Smit, J.H., Middeldorp, C.M., Ripke, S., M L Pergadia, Hickie, I B, de Geus, E.J., Wray, NR, Van Den Oord, E. J. C. G., Wray, N. R., Blackwood, DHR, de Geus, E J C, Penninx, B.W., B P McEvoy, McGhee, K. A., Middeldorp, C. M., Byrne, E. M., McEvoy, B. P., Macgregor, S, E J C G van den Oord, Statham, D J, Heath, A C, Lewis, C. M., van den Oord, E.J.C.G., I B Hickie, Willemsen, G., Pergadia, M.L., Medland, S.E., Sullivan, P. F., Penninx, B.W.J.H., Heath, A. C., Maclean, AW, Nyholt, D. R., N R Wray, S Macgregor, MacIntyre, DJ, Boomsma, D.I., G W Montgomery, Lewis, C M, Henders, A K, Madden, P. A. F., Madden, P.A.F., Henders, A.K., Hottenga, J J, McGuffin, P., Boomsma, D I, Madden, P.A., de Geus, E.J.C.; id_orcid, Oord, E.J.C.G. van den, Henders, A. K., Wray, N R, Madden, P A F, E J C de Geus, Pergadia, ML, D R Nyholt, Maclean, A W, Ripke, S, A C Heath, Ripke, Stephan, MacIntyre, D. J., Geus, E.J.C. de, Blackwood, D. H. R., Statham, D. J., Penninx, B W J H, Macgregor, S., Gordon, S. D., McGhee, KA, D J MacIntyre, Nyholt, D R, Wray, N.R., Middeldorp, C M, Liu, J Z, S Ripke, K A McGhee, P McGuffin, Nyholt, DR, Willemsen, G, Boomsma, D.I.; id_orcid, Lewis, C. M.; id_orcid, Martin, N G, Blackwood, D H R, Liu, J.Z., Byrne, E M, MacIntyre, D.J.   +145 more
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Genome-wide somatic hypermutation [PDF]

Proceedings of the National Academy of Sciences, 2004
DNA mutagenesis is generally considered harmful. Yet activated B cells normally mutate the Ig loci. Because this somatic hypermutation is potentially dangerous, it has been hypothesized that mutations do not occur throughout the genome but instead are actively targeted to the Ig loci.
Clifford L, Wang, Ryan A, Harper, Matthias, Wabl   +2 more
openaire   +2 more sources

A Genome-Wide Investigation of SNPs and CNVs in Schizophrenia [PDF]

, 2009
We report a genome-wide assessment of single nucleotide polymorphisms (SNPs) and copy number variants (CNVs) in schizophrenia. We investigated SNPs using 871 patients and 863 controls, following up the top hits in four independent cohorts comprising 1 ...
Rujescu, D., Herbert Y Meltzer, Fraser, G., Gennarelli, Massimo, St. Clair, D, JAYATHILAKE K, Rossi Giuseppe, Feng, S, Gennarelli Massimo, Feng, Sheng, Fraser, G, KASPERAVICI, Ge, D., MELTZER HY, Strittmatter, WJ, Fisher, EMC, St Clair, David, RUPPERT A, ROSES AD, Rossi, Giuseppe, Ge Dongliang, Ge, DL, YOON W, NEED AC, David St Clair, RUJESCU D, Sheng Feng, Joseph P McEvoy, Meltzer, Herbert Y, Goldstein, DB, Yoon, Woohyun, St. Clair David, Goldstein, D., Lefkos T Middleton, Meltzer, H., Feng, S., Allen D Roses, Hartmann, Annette M., St Jean, PL, Middleton, Lefkos T., David B Goldstein, Yoon, W, Kasperaviciute, Dalia, Shianna, Kevin V, Moller, HJ, TE D, GOLDSTEIN DB, Kasperavičiūtė, D., Weale, Michael E., Meltzer, HY, FRASER G, Ruppert, A., Middleton, Lefkos T, St Jean, Pamela L, WEALE ME, Shianna, K., Fisher, Elizabeth M. C., Middleton Lefkos T., Heinzen Erin L., Heinzen, E., Crombie Caroline, Ina Giegling, McEvoy, Joseph P, Bonvicini, Cristian, Pamela L St Jean, St. Jean, Pamela L., Keefe, RSE, MÖLLER HJ, Heinzen, EL, Maia, J, Caroline Crombie, Hartmann, A., Need, Anna C, Muglia Pierandrea, Francks, Clyde, St Clair, D, FISHER EM, Dongliang Ge, Giegling Ina, Moeller, H-J, Pierandrea Muglia, Fisher Elizabeth M. C., Goldstein, David B, McEvoy, J., COLA PA, St. Jean Pamela L., Feng Sheng, Cola Philip A., Kasperaviciute, D, Kevin V Shianna, Need Anna C., Weale Michael E., Goldstein, David B., Jessica Maia, Giegling, I., Francks Clyde, Bonvicini, C., Muglia, P., Strittmatter, Warren J., Yoon, W., Ge, Dongliang, McEvoy, JP, Clyde Francks, ROSSI G, Gillian Fraser, Möller, H., Strittmatter, W., MCEVOY JP, St. Clair, D., Ruppert Andreas, Meltzer, Herbert Y., Shianna Kevin V., Fraser, Gillian, Cristian Bonvicini, Roses, Allen D., Gennarelli, M, Warren J Strittmatter, Moeller, Hans-Juergen, Meltzer Herbert Y., Fisher, E., CROMBIE C, Need, AC, Michael E Weale, Ruppert, A, Kasperavičiūtė Dalia, HEINZEN EL, Hartmann, AM, KEEFE RS, Giegling, I, Möller, Hans-Jürgen, Dan Rujescu, Bonvicini Cristian, Goldstein David B., ST CLAIR D, Need, A., Erin L Heinzen, Annette M Hartmann, Heinzen, Erin L, Francks, C, Elizabeth M C Fisher, Gennarelli, M., Muglia, Pierandrea, MIDDLETON LT, Richard S E Keefe, HARTMANN AM, Shianna, KV, Rujescu, Dan, McEvoy Joseph P., Crombie, C., Crombie, Caroline, Strittmatter, Warren J, Woohyun Yoon, Rujescu Dan, St. Jean, P., Ge, D, Karu Jayathilake, McEvoy, Joseph P., Cola, Philip A., Keefe, Richard S E, Jayathilake Karu, Anna C Need, Jayathilake, K., Giegling, Ina, FENG S, Yoon Woohyun, Middleton, LT, Heinzen, Erin L., Roses, Allen D, Cola, PA, Cola, Philip A, St. Clair, David, GE D, Andreas Ruppert, Strittmatter Warren J., Bonvicini, C, St. Jean, PL, Weale, M., Shianna, Kevin V., Cola, P., Rujescu, D, Philip A Cola, Giuseppe Rossi, Middleton, L., Möller Hans-Jürgen, Jayathilake, K, Weale, ME, Jayathilake, Karu, Roses, AD, FRANCKS C, MAIA J, Hartmann, Annette M, Keefe, R., Rossi, G., Roses Allen D., Muglia, P, ST JEAN PL, Roses, A., Fisher, Elizabeth M C, BONVICINI C, Ruppert, Andreas, Maia, Jessica, Massimo Gennarelli, Maia Jessica, GIEGLING I, Francks, C., Keefe Richard S. E., SHIANNA KV, Maia, J., MUGLIA P, Rossi, G, Dalia Kasperaviciūte, Fraser Gillian, Crombie, C, Weale, Michael E, Hartmann Annette M., Need, Anna C., Keefe, Richard S. E., Hans-Jürgen Möller, STRITTMATTER WJ   +218 more
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Creating a RAW264.7 CRISPR-Cas9 Genome Wide Library

Bio-Protocol, 2017
The bacterial clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 genome editing tools are used in mammalian cells to knock-out specific genes of interest to elucidate gene function.
Brooke Napier , Denise Monack
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Genome‐wide insights into introgression and its consequences for genome‐wide heterozygosity in the Mytilus species complex across Europe

Evolutionary Applications, 2020
The three mussel species comprising the Mytilus complex are widespread across Europe and readily hybridize when they occur in sympatry, resulting in a mosaic of populations with varying genomic backgrounds. Two of these species, M.
David L. J. Vendrami, Michele De Noia, Luca Telesca, Eva‐Maria Brodte, Joseph I. Hoffman   +4 more
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First genome-wide association study on anxiety-related behaviours in childhood [PDF]

, 2013
Background: Twin studies have shown that anxiety in a general population sample of children involves both domain-general and trait-specific genetic effects.
Hanscombe, K.B., Oliver S. P. Davis, Plomin, Robert, Maciej Trzaskowski (185577), Hanscombe, Ken B, Doherty, Sophia J, Thomas Price, Haworth, C., Haworth, Claire M. A., Ken B Hanscombe, Robert Plomin (27675), Davis, OS, Haworth, Claire M A, Thalia C Eley, Sophia J. Doherty, Eley, Thalia C, Price, T.S, Hanscombe, KB, Eley Thalia C., Doherty, Sophia J., Eley, Thalia C., Oliver S P Davis, Claire M. A. Haworth (185578), Price, T, Oliver S. P. Davis (185580), Robert Plomin, Doherty, SJ, Maciej Trzaskowski, Claire M A Haworth, Haworth, CM, Thalia C. Eley (397316), Price Thomas, Davis, O.S.P., Haworth Claire M. A., Trzaskowski, Maciej, Claire M. A. Haworth, Davis, Oliver S P, Price, Thomas, Meaburn, Emma L, Thomas Price (397319), Thalia C. Eley, Eley, T.C., Davis Oliver S. P., Trzaskowski, M., Hanscombe Ken B., Docherty, Sophia J., Meaburn Emma L., Meaburn, EL, Davis, Oliver S. P., Emma L. Meaburn, Ken B. Hanscombe (185575), Plomin, R., Sophia J. Doherty (397317), Meaburn, Emma L., Price, Tom S., Plomin Robert, Sophia J Doherty, Doherty, S.J., Trzaskowski, M, Hanscombe, Ken B., Ken B. Hanscombe, Plomin, R, Emma L. Meaburn (397318), Eley, TC, Trzaskowski Maciej, Emma L Meaburn, Doherty Sophia J.   +66 more
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Novel approach for deriving genome wide SNP analysis data from archived blood spots [PDF]

, 2012
BACKGROUND: The ability to transport and store DNA at room temperature in low volumes has the advantage of optimising cost, time and storage space.
Walling, Grant A, Fowler Katie E, Fowler, K., Fowler, Katie E., Griffin, Darren K, Griffin, D., Reitter, Chris P, Reitter Chris P, Griffin Darren K, Griffin, Darren K., Reitter, C., Walling, G., Walling Grant A   +12 more
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Enhancing the genome editing toolbox: genome wide CRISPR arrayed libraries

Scientific Reports, 2017
CRISPR-Cas9 technology has accelerated biological research becoming routine for many laboratories. It is rapidly replacing conventional gene editing techniques and has high utility for both genome-wide and gene-focussed applications.
Emmanouil Metzakopian, Alex Strong, Vivek Iyer, Alex Hodgkins, Konstantinos Tzelepis, Liliana Antunes, Mathias J Friedrich, Qiaohua Kang, Teresa Davidson, Jacob Lamberth, Christina Hoffmann, Gregory D. Davis, George S. Vassiliou, William C. Skarnes, Allan Bradley   +14 more
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