Results 21 to 30 of about 3,210,341 (315)

Genome wide analysis of Arabidopsis core promoters

open access: yesBMC Genomics, 2005
Background Core promoters are the gene regulatory regions most proximal to the transcription start site (TSS), central to the formation of pre-initiation complexes and for combinatorial gene regulation.
Molina Carlos, Grotewold Erich
doaj   +1 more source

Genome-wide significance for dense SNP and resequencing data. [PDF]

open access: yes, 2008
The problem of multiple testing is an important aspect of genome-wide association studies, and will become more important as marker densities increase.
Whittaker, John C   +4 more
core   +1 more source

Genome-Wide Association Studies of the PR Interval in African Americans [PDF]

open access: yes, 2011
The PR interval on the electrocardiogram reflects atrial and atrioventricular nodal conduction time. The PR interval is heritable, provides important information about arrhythmia risk, and has been suggested to differ among human races.
Paltoo, Dina N.   +180 more
core   +1 more source

Genome-Wide Association Study Identifies Novel Restless Legs Syndrome Susceptibility Loci on 2p14 and 16q12.1 [PDF]

open access: yes, 2011
Restless legs syndrome (RLS) is a sensorimotor disorder with an age-dependent prevalence of up to 10% in the general population above 65 years of age. Affected individuals suffer from uncomfortable sensations and an urge to move in the lower limbs that ...
Juliane Winkelmann   +328 more
core   +1 more source

A concise history of genome-wide association studies

open access: yesSaudi Journal of Medicine and Medical Sciences, 2013
Genome-wide association studies (GWASs) have had a tremendous impact on the pace of genomic research of common diseases. The number of identified genetic variants associated has grown exponentially. For some diseases, such as coronary heart disease (CHD),
Bobby P. C. Koeleman   +3 more
doaj   +1 more source

H3AGWAS: a portable workflow for genome wide association studies

open access: yesBMC Bioinformatics, 2022
Background Genome-wide association studies (GWAS) are a powerful method to detect associations between variants and phenotypes. A GWAS requires several complex computations with large data sets, and many steps may need to be repeated with varying ...
Jean-Tristan Brandenburg   +6 more
doaj   +1 more source

Meta-analysis of genome-wide association studies identifies novel loci that influence cupping and the glaucomatous process [PDF]

open access: yes, 2014
Glaucoma is characterized by irreversible optic nerve degeneration and is the most frequent cause of irreversible blindness worldwide. Here, the International Glaucoma Genetics Consortium conducts a meta-analysis of genome-wide association studies of ...
Springelkamp, H   +667 more
core   +1 more source

A genome‐wide investigation of food addiction [PDF]

open access: yesObesity, 2016
ObjectiveEvidence of parallels between drug addiction and eating behavior continues to accumulate. Genetic studies of addictive substances have yielded a number of susceptibility loci that point to common higher order genetic pathways underlying addiction.
Cornelis, Marilyn   +6 more
openaire   +4 more sources

Genome-Wide Joint Meta-Analysis of SNP and SNP-by-Smoking Interaction Identifies Novel Loci for Pulmonary Function [PDF]

open access: yes, 2012
Genome-wide association studies have identified numerous genetic loci for spirometic measures of pulmonary function, forced expiratory volume in one second (FEV1), and its ratio to forced vital capacity (FEV1/FVC).
Wenbo Tang (110161)   +678 more
core   +1 more source

Adiposity-Related Heterogeneity in Patterns of Type 2 Diabetes Susceptibility Observed in Genome-Wide Association Data [PDF]

open access: yes, 2009
OBJECTIVE-This study examined how differences in the BMI distribution of type 2 diabetic case subjects affected genome-wide patterns of type 2 diabetes, association mid considered the implications for the etiological heterogeneity of type 2 diabetes ...
Timpson, NJ   +53 more
core   +1 more source

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