Results 121 to 130 of about 53,124 (263)

Structural Basis of the Membrane Association by the Conserved RocS Membrane‐Targeting Sequence in Streptococcus

Advanced Science, EarlyView.
Chromosome segregation in Streptococcus pneumoniae depends on RocS, a bitopic protein whose membrane‐anchoring mechanisms were unclear. Using NMR and AFM, this study reveals that the widely conserved RocS anchor binds to membranes via a conserved kink‐helix motif which inserts into lipid nanodomains.
Ana Álvarez‐Mena, Estelle Morvan, Clara Lambert, Anagha Kallisseri Parambil, Martin Lefeuvre, Zeren Xu, Nadia El Mammeri, Florian Malard, Erick J. Dufourc, Cécile Feuillie, Christophe Grangeasse, Birgit Habenstein   +11 more
wiley   +1 more source

Coronavirus Nsp3 Hijacks CLTC to Modulate Autophagosome Nucleation for Promoting DMV Formation and Viral Replication

Advanced Science, EarlyView.
In wild‐type cells, FIPV infection recruits CLTC to nsp3, facilitates DMV biogenesis and block autophagic flux to promote viral replication. CLTC knockout impairs autophagosome nucleation by reducing Beclin1–ATG14 complex expression. This disrupts the formation of autophagic precursor membranes, thereby preventing their hijacking by nsp3 for DMV ...
Juan Xu, Hang Li, Peng Liu, Zhe Jiao, Ding Zhang, Zhelin Su, Sai Niu, Jintao Zhang, Yuejun Shi, Guiqing Peng   +9 more
wiley   +1 more source

Kinetic Traps in RNA Folding: Targeted Design of Frameshifting Element Mutants by Thermodynamic and Kinetic Analysis of the Chikungunya Virus. [PDF]

J Phys Chem B
Lee S, Schlick T.
europepmc   +1 more source

Emerging of Anomalous Higher‐Order Topological Phases in Altermagnet/Topological Insulator Heterostructure by Floquet Engineering

Advanced Science, EarlyView.
We combine altermagnet with topological insulators and subject the structure to Floquet driving. This breaks time‐reversal symmetry and creates a new type of higher‐order topological insulator. Its key feature is the emergence of programmable “0/π‐corner modes” that can be controlled by magnetic field direction, offering a novel dynamic platform for ...
Donghao Wang, Arnob Kumar Ghosh, Yongchun Tao, Fusheng Ma, Cheng Song   +4 more
wiley   +1 more source

Molecular identifiers of the evolutionarily conserved titin pseudokinase. [PDF]

Biochem J
Dorendorf T, Gravenhorst P, Mayans O.
europepmc   +1 more source

Advanced Corneal Hydrogels: From Passive Replacement to Active Regeneration and Intelligent Interaction

Advanced Science, EarlyView.
This review charts the evolution of corneal hydrogels from passive replacements to active and intelligent systems, evaluating natural and synthetic materials while addressing design challenges such as transparency and strength. Advanced applications such as scarless wound healing, three‐dimensional bioprinting, and smart wearables are highlighted to ...
Xinwei Wang, Wen Zhou, Haotian Xue, Wenjun Xue, Guangping Gao, Bing Zhu, Hongyuan Song, Qingqiang Xu, Jing Zhao, Wei Shen   +9 more
wiley   +1 more source

Linking hierarchical classification of transcription factors by the structure of their DNA-binding domains to the variability of their binding site motifs. [PDF]

Vavilovskii Zhurnal Genet Selektsii
Levitsky VG, Vatolina TY, Raditsa VV.
europepmc   +1 more source

Extreme Kinetic Stability and RNase Resistance of Human Telomerase RNA G‐Quadruplexes Overcome by DHX36 Helicase

Advanced Science, EarlyView.
The RNA G‐quadruplexes formed at the 5'‐end of the RNA component of human telomerase possess extreme slow unfolding rate, rendering them resistant to nuclease degradation. The helicase DHX36 overcame this kinetic barrier and significantly reduced the folded fraction.
Qun Luo, Yashuo Zhang, Yingxian Qian, Huiying Zhan, Wenqiang Wu, Huijuan You   +5 more
wiley   +1 more source

Allosteric Regulation of RNA Affinity by Motif V-VI Coupling in West Nile Virus NS3 Helicase. [PDF]

Proteins
Roy P, McCullagh M.
europepmc   +1 more source

Rapid Design and Fabrication of Body Conformable Surfaces with Kirigami Cutting and Machine Learning

Advanced Science, EarlyView.
By integrating the principles of kirigami cutting and data‐driven modeling, this study aims to develop a personalized, rapid, and low‐cost design and fabrication pipeline for creating body‐conformable surfaces around the knee joint. This pipeline presents a balanced trade‐off between conformability performance and cost for personalizing wearables, thus
Jyotshna Bali, Jinyang Li, Jie chen, Suyi Li   +3 more
wiley   +1 more source