Results 11 to 20 of about 53,124 (263)

The Helix-Loop-Helix motif of human EIF3A regulates translation of proliferative cellular mRNAs [PDF]

PLOS ONE, 2018
Improper regulation of translation initiation, a vital checkpoint of protein synthesis in the cell, has been linked to a number of cancers. Overexpression of protein subunits of eukaryotic translation initiation factor 3 (eIF3) is associated with increased translation of mRNAs involved in cell proliferation.
Marina P. Volegova, Cynthia Hermosillo, Jamie H.D. Cate   +2 more
openaire   +5 more sources

A genome-wide identification of basic helix-loop-helix motifs in Pediculus humanus corporis (Phthiraptera: Pediculidae). [PDF]

J Insect Sci, 2014
Basic helix-loop-helix (bHLH) proteins comprise a large superfamily of transcription factors, which are involved in the regulation of various developmental processes. bHLH family members are widely distributed in various eukaryotes including yeast, fruit fly, zebrafish, mouse, and human.
Wang XH, Wang Y, Zhang DB, Liu AK, Yao Q, Chen KP.   +5 more
europepmc   +4 more sources

Regulation of TCF ETS-domain transcription factors by helix-loop-helix motifs [PDF]

Nucleic Acids Research, 2003
DNA binding by the ternary complex factor (TCF) subfamily of ETS-domain transcription factors is tightly regulated by intramolecular and intermolecular interactions. The helix-loop-helix (HLH)-containing Id proteins are trans-acting negative regulators of DNA binding by the TCFs.
Stinson J, Inoue T, Yates P, Clancy A, Norton JD, Sharrocks AD   +5 more
openaire   +4 more sources

Characterization of a Putative Helix-Loop-Helix Motif in Nucleotide Excision Repair Endonuclease, XPG [PDF]

Journal of Biological Chemistry, 1997
Complementation group G of xeroderma pigmentosum (XPG) is one of the most rare and pathophysiologically heterogeneous forms of this inherited disease. XPG patients exhibit varying phenotypes, from having a very mild defect in DNA repair to being severely affected, and a few cases are also associated with the neurological degeneracy and growth ...
M S, Park, J, Valdez, L, Gurley, C Y, Kim   +3 more
openaire   +2 more sources

Genome-wide analysis of basic helix-loop-helix transcription factors in papaya (Carica papaya L.) [PDF]

PeerJ, 2020
The basic helix-loop-helix (bHLH) transcription factors (TFs) have been identified and functionally characterized in many plants. However, no comprehensive analysis of the bHLH family in papaya (Carica papaya L.) has been reported previously.
Min Yang, Chenping Zhou, Hu Yang, Ruibin Kuang, Bingxiong Huang, Yuerong Wei   +5 more
doaj   +2 more sources

Gli3 utilizes Hand2 to synergistically regulate tissue-specific transcriptional networks

eLife, 2020
Despite a common understanding that Gli TFs are utilized to convey a Hh morphogen gradient, genetic analyses suggest craniofacial development does not completely fit this paradigm.
Kelsey H Elliott, Xiaoting Chen, Joseph Salomone, Praneet Chaturvedi, Preston A Schultz, Sai K Balchand, Jeffrey D Servetas, Aimée Zuniga, Rolf Zeller, Brian Gebelein, Matthew T Weirauch, Kevin A Peterson, Samantha A Brugmann   +12 more
doaj   +1 more source

Genome-wide identification and expression analysis of the Trihelix transcription factor family in potato (Solanum tuberosum L.) during development [PDF]

PeerJ
Trihelix transcription factors (TF) are photoresponsive proteins featuring a characteristic three-helix structure (helix-loop-helix-loop-helix) and contain the Myb/SANT-LIKE (MSL) domain.
Chao Mei, Yuwei Liu, Huiyang Song, Jinghao Li, Qianna Song, Yonghong Duan, Ruiyun Feng   +6 more
doaj   +2 more sources

Transcriptome-wide characterization of bHLH transcription factor genes in Lycoris radiata and functional analysis of their response to MeJA

Frontiers in Plant Science, 2023
As one of the biggest plant specific transcription factor (TF) families, basic helix–loop–helix (bHLH) protein, plays significant roles in plant growth, development, and abiotic stress responses. However, there has been minimal research about the effects
Ning Wang, Xiaochun Shu, Fengjiao Zhang, Zhong Wang   +3 more
doaj   +1 more source

Diversification of DNA binding specificities enabled SREBP transcription regulators to expand the repertoire of cellular functions that they govern in fungi.

PLoS Genetics, 2018
The Sterol Regulatory Element Binding Proteins (SREBPs) are basic-helix-loop-helix transcription regulators that control the expression of sterol biosynthesis genes in higher eukaryotes and some fungi.
Valentina Del Olmo Toledo, Robert Puccinelli, Polly M Fordyce, J Christian Pérez   +3 more
doaj   +1 more source

Characterization of a helix‐loop‐helix (EF hand) motif of silver hake parvalbumin isoform B [PDF]

Protein Science, 1997
AbstractParvalbumins are a class of calcium‐binding proteins characterized by the presence of several helix‐loop‐helix (EF‐hand) motifs. It is suspected that these proteins evolved via intragene duplication from a single EF‐hand. Silver hake parvalbumin (SHPV) consists of three EF‐type helix‐loop‐helix regions, two of which have the ability to bind ...
S P, Revett, G, King, J, Shabanowitz, D F, Hunt, K L, Hartman, T M, Laue, D J, Nelson   +6 more
openaire   +2 more sources