Results 191 to 200 of about 53,124 (263)

Mini‐Hairpin DNA: Extraordinarily Stable Structure and Its Applications

Chemistry – A European Journal, EarlyView.
Mini‐hairpin DNA fragments containing GCGAAGC and GCGAAAGC form exceptionally stable hairpin‐like structures, with only two G−C pairs and one sheared G−A pair, remaining undenatured in 7 M urea and resisting nuclease digestion. These mini‐hairpin sequences frequently appear in replication and transcription origins, influence DNA sequencing fidelity ...
Michiko Kimoto, Ichiro Hirao
wiley   +1 more source

Designer RNA nanostructures co-transcribed and self-assembled inside human cell nuclei. [PDF]

Nat Commun
Chang X, Jeziorek M, Yang Q, Bonder EM, Yan H, Etchegaray JP, Zhang F.   +6 more
europepmc   +1 more source

A Bifunctional Small Molecule Degrader of the Long Noncoding RNA MALAT1 Triplex

Chemistry – A European Journal, EarlyView.
Targeting disease‐linked RNAs with small molecules is often limited by the modest impact of binding RNA structure alone. Here, we present a first‐in‐class bifunctional molecule that degrades the oncogenic lncRNA MALAT‐1 by inducing proximity between the RNA and a cleaving warhead.
Christian A. T. Brega, Benjamin A. Craig, Sigitas Mikutis, Rupert S. J. Proctor, Yuliia Vyborna, Maria Eleftheriou, Kostas Tzelepis, Mo Yang, Shaifaly Parmar, Javier Bonet‐Aleta, John S. Schneekloth Jr., Gonçalo J. L. Bernardes   +11 more
wiley   +1 more source

How conformational changes near the F pocket of MHC class I proteins mediate chaperone assisted peptide loading. [PDF]

Front Immunol
Göppert S, Springer S, Zacharias M.
europepmc   +1 more source

Chemical Ligation of Backbone N‐hydroxylated Peptides

Chemistry – A European Journal, EarlyView.
Peptide backbone N‐hydroxylation enables sequence‐agnostic fragment ligation via hydroxamate O‐acyl capture and O→N acyl transfer in water. Broad tolerance of sterically demanding nucleophilic residues is observed, and reductive N─O cleavage restores the native amide bond.
Natalia Cano‐Sampaio, Juan R. Del Valle   +1 more
wiley   +1 more source

Complex cooperativity in DNA origami revealed via design-dependent defectivity. [PDF]

Nucleic Acids Res
Majikes JM, Hasni A, Haridas S, Robertson JWF, Pintar AL, Zwolak M, Liddle JA.   +6 more
europepmc   +1 more source

Post‐LECA Origin and Diversification of an Axonemal Outer Arm Dynein Motor

Cytoskeleton, EarlyView.
ABSTRACT Dyneins were present in the last eukaryotic common ancestor (LECA) and play key roles in eukaryotic biology. Axonemal dyneins form the inner and outer arms that power ciliary beating, and it has long been recognized that outer arms in some organisms contain two different heavy chain motors, whereas those from other species contain a third unit
Stephen M. King
wiley   +1 more source

<i>In silico</i> reconstruction of a salmonid alphavirus virion reveals distinctive molecular features implicated in virulence. [PDF]

iScience
Biacchesi S, Fauvet C, Mérour E, Bernard J, Lamoureux A, Lallias D, Millet JK.   +6 more
europepmc   +1 more source

Enhancing Knowledge and Technology Transfer: Determinants and Indicators of Successful University–Industry Collaboration

Corporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT Both universities and companies create value and innovation to maintain their position and remain competitive. Different, but still similar, with two goals that are shared. With their collaboration, they can enhance their pursuit of sustainability and as well corporate social responsibility by creating and delivering value and thus ...
Jana Hojnik, Štefan Bojnec, Simona Kustec, Vaida Zemlickienė, Zenonas Turskis   +4 more
wiley   +1 more source

Translocation mechanism of xeroderma pigmentosum group D protein on single-stranded DNA and genetic disease etiology. [PDF]

Nat Commun
Paul T, Yan C, Derdeyn-Blackwell G, Ivanov I.   +3 more
europepmc   +1 more source