Gutted adenoviral vector growth using E1/E2b/E3-deleted helper viruses [PDF]
Journal of Gene Medicine, 2002 AbstractBackgroundHelper‐dependent, or gutted, adenoviruses (Ad) lack viral coding sequences, resulting in reduced immunotoxicity compared with conventional Ad vectors. Gutted Ad growth requires a conventional Ad to supply replication and packaging functions in trans.
Jeffrey Chamberlain
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Mathematical Models of Host Plant Infection by Helper-Dependent Virus Complexes: Why Are Helper Viruses Always Avirulent? [PDF]
Phytopathology, 2000 Interactions between viruses in plants are common, and some viruses depend on such interactions for their survival. Frequently, a virus lacks some essential molecular function that another provides. In “helper-dependent” virus complexes, the helper virus is transmitted independently by a vector, whereas the dependent virus depends on molecular agents ...
J Colvin
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Isolation of Helper Viruses from Preparations of Hamster-specific Sarcoma Viruses
Journal of General Virology, 1971 Summary Non-transforming helper viruses were isolated from pools of two hamster-specific sarcoma viruses in which isolations by terminal dilution procedures had previously been unsuccessful. This presumably resulted from approximately equivalent levels of sarcoma and helper viruses in the original pools.
G J Kelloff, R V Gilden, R J Huebner
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The helper strategy in vector-transmission of plant viruses
Peer Community Journal, 2023 An intriguing aspect of vector-transmission of plant viruses is the frequent involvement of a helper component (HC). HCs are virus-encoded non-structural proteins produced in infected plant cells that are mandatory for the transmission success. Over five
Di Mattia, Jérémy +3 more
doaj +5 more sources
5'-terminal nucleotide sequences of mammalian type C helper viruses are conserved in the genomes of replication-defective mammalian transforming viruses [PDF]
Journal of Virology, 1978 The RNAs of replication-defective murine and primate type C transforming viruses were analyzed for the presence of nucleotide sequences homologous to the genomes of their respective helper type C viruses by using DNAs complementary (cDNA) to either the 5'-terminal (cDNA5') or total (cDNAtotal) nucleotide sequences of the helper virus RNA. The defective
Stuart Aaronson +2 more
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In vitro interactions between cucumoviral satellite RNAs and RNAs of helper and non-helper viruses
Physiological and Molecular Plant Pathology, 1993 A model, previously proposed for the interaction of the satellite RNAs with the genomic RNAs of cucumber mosaic virus (CMV), has been evaluated experimentally.
A. Fraile +2 more
semanticscholar +2 more sources
Construction of Recombinant Vaccinia Viruses Using PUV-Inactivated Virus as a Helper [PDF]
BioTechniques, 2001 Recombinant vaccinia viruses (VVs) are widely used as expression vectors in molecular biology and immunology and are now under evaluation for gene therapy.
Tatyana M. Timiryasova +3 more
doaj +3 more sources
Demonstration of Insect Vector-Mediated Transfer of a Betasatellite between Two Helper Viruses [PDF]
VirusesBegomoviruses, transmitted by the whitefly Bemisia tabaci, pose significant threats to global agriculture due to their severe impact on various crops.
Noun Fouad +4 more
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An siRNA Screen Identifies the U2 snRNP Spliceosome as a Host Restriction Factor for Recombinant Adeno-associated Viruses. [PDF]
PLoS Pathogens, 2015 Adeno-associated viruses (AAV) have evolved to exploit the dynamic reorganization of host cell machinery during co-infection by adenoviruses and other helper viruses.
Claire A Schreiber +9 more
doaj +2 more sources
Rauscher spleen focus-forming virus: biological properties and relationship to helper viruses.
Journal of General Virology, 1982 A Rauscher virus (RV)-transformed erythroid cell line, RA-1, was shown to be a non-producer cell line. RA-1 cells express not only gp51-54 env-related glycoprotein, but also gp70, which is more closely related to gp51-54 coded by a recombinant env gene than to the MuLV-R gp70.
J. N. Mol +3 more
semanticscholar +3 more sources