Results 51 to 60 of about 38,345 (239)
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
ISPRS International Journal of Geo-InformationThe COVID-19 outbreak followed by the strict citywide lockdown in Shanghai has sparked negative emotion surges on social media platforms in 2022. This research aims to investigate the spatial–temporal heterogeneity of a unique emotion (helplessness) and ...
Yuhao He +4 more
doaj +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Trato y maltrato: una mirada psicoanalítica
Cuestiones de Género: de la Igualdad y la Diferencia, 2008 Veremos las razones por las que tratamientos con maltratadas fracasan. Repasaremos con Freud el devenir mujer: el desamparo radical del ser humano —la Hilflosighkeit freudiana— tiene connotaciones de cataclismo para las mujeres, y con él se confrontan ...
María Cruz Estada
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Psychosocial Problems of Thalassemic in A Tertiary Care Centre, Indore
National Journal of Community Medicine, 2016 Introduction: Chronicity of thalassemia is a powerful source of emotional problems. During adolescence and young adulthood various complications may occur and patient under goes a period of psychological readjustment. Material and Methods: This was a
Sameer Inamdar, Anila Gangrade
doaj
Indian Journal of Respiratory Care, 2018 Introduction: Mortality attributable to chronic obstructive pulmonary disease (COPD) in India is estimated to be among the highest in the world. Although identification and management of symptoms and signs of chronic lung diseases have improved, the ...
Akshee Batra +2 more
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Development of Personality with Learned Helplessness at Different Stages of Ontogenesis
Вестник Кемеровского государственного университета, 2020 Learned helplessness was discovered by American positivists in the 1970s. There are two approaches to learned helplessness: as a phenomenon (state) and as a process.
O. V. Volkova
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