Results 61 to 70 of about 195,584 (302)
ABSTRACT Background Neuromyelitis optica spectrum disorder (NMOSD) is a relapsing autoimmune disease of the central nervous system. High‐dose intravenous methylprednisolone (IVMP) is the standard first‐line therapy for acute attacks, although some patients remain refractory.
Wataru Horiguchi +5 more
wiley +1 more source
Mapping the evolution of mitochondrial complex I through structural variation
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin +2 more
wiley +1 more source
Trauma e Infância : Considerações sobre a Vivência de Situações Potencialmente Traumáticas
RESUMOA partir da teoria freudiana, o artigo propõe uma discussão em torno do lugar ocupado pelo acontecimento na constituição do trauma. O principal ponto de interesse consiste em pensar as conseqüências da vivência, ainda na infância, de acontecimentos
Dione de Medeiros Lula Zavaroni +1 more
doaj +1 more source
Objectives of the research: This article presents a diagnosis of the learned helplessness experienced by secondary-school students learning English remotely during the 2021 lockdown due to the COVID-19 pandemic.
Magdalena Kolber
doaj +1 more source
Incorporating family function into chronic pain disability: the role of catastrophizing [PDF]
Background. Observers' responses to pain are recently investigated to more comprehensively explain chronic pain (CP) and disability. However, the role of family context, defined as interference in roles, communication, and problem-solving, and how (i.e.,
Akbari, F +3 more
core +7 more sources
The newfound relationship between extrachromosomal DNAs and excised signal circles
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
The Trouble with Trible: The Limitation of a Feminist Biblical Interpretation [PDF]
In lieu of an abstract, below is the essay\u27s first paragraph: In her book, Texts of Terror: Literary-Feminist Readings of Biblical Narratives, Phyllis Trible describes the story of the unnamed concubine in the Book of Judges as depicting “the horrors ...
MacCammon, Linda
core +1 more source
Helpless Wishful Thinking [PDF]
I wish to criticize the fact that wound irrigation with infusion catheters or button cannulas, which are inserted into the full depth of the bite wound in order to remove foreign bodies and pathogens (1) is described as an apparently common method and in such a neutral fashion. Only “irrigation under pressure is inadvisable”.
openaire +2 more sources
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source

