Results 61 to 70 of about 40,335 (261)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Mentors' resources and premature match closure in challenging contexts: testing a model of mediating processes in an online and a school-based mentoring program

Frontiers in Psychology
IntroductionThis research aimed to investigate the impact of mentors' resources on the premature termination of mentoring relationships in challenging contexts as well as mediating psychological processes.MethodIn two studies, we analyzed the data of 98 ...
Sonja Bayer, Heidrun Stoeger, Albert Ziegler   +2 more
doaj   +1 more source

THE GEOPOLITICS OF HELPLESSNESS [PDF]

CES Working Papers, 2014
The events in Ukraine are in the thick of actuality, at the crossroads of East and West. From a buffer zone it has become an acute space of exhibition of Russia’s interests, on one side, and of the European Union’s, on the other side. As the EU does not have a unique army or a strong political leadership, the presence - as major actors - of NATO and ...
openaire   +2 more sources

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Specifics of Relationship Between Stress and Helplessness in Adolescence

Теоретическая и экспериментальная психология
Background. The article considers the problem of helplessness and its contribution to the experience of everyday and traumatic stress. The relevance of the analysis of psychological aspects of helplessness is due to its currently ambiguous ...
Natalya E. Kharlamenkova
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Predictors of poor medication adherence in patients undergoing peritoneal dialysis: a LASSO-based risk model from a cross-sectional study in Xinjiang, China

Renal Failure
Medication nonadherence is a major challenge in peritoneal dialysis, yet predictive tools are available. This study aimed to identify key determinants of poor medication adherence and develop a clinically applicable prediction model.
Hui Liu, Hong Tan, Li Li
doaj   +1 more source

The Effectiveness of Interpersonal Psychotherapy on Generalized Anxiety and Helplessness Due to Complicated Grief in Female Survivors of COVID-19 Deaths [PDF]

مجله علوم پزشکی صدرا
Introduction: This present study aimed to investigate the effectiveness of interpersonal psychotherapy (IPT) in reducing generalized anxiety and helplessness resulting from complicated grief in female survivors of COVID-19 victims.
Elham Mohammad Barzi, Roghayeh Kiyani
doaj   +1 more source