Results 61 to 70 of about 52,296 (305)
FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Modeling of demoralization in breast cancer
Frontiers in PsychiatryObjectiveThis study aimed at identifying correlates of demoralization in breast cancer.Materials and methodsInformation was obtained from outpatients with breast cancer at the Oncology Clinic of a university-affiliated hospital in the United States ...
John M. de Figueiredo +3 more
doaj +1 more source
Learned helplessness in humans: Critique and reformulation. [PDF]
, 1978 The learned helplessness hypothesis is criticized and reformulated. The old hypothesis, when applied to learned helplessness in humans, has two major problems: (a) It does not distinguish between cases in which outcomes are uncontrollable for all people ...
Martin E P Seligman +2 more
core
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
A Developmental Study of Learned Helplessness [PDF]
, 1980 Examined susceptibility to learned helplessness among 20 children from each of kindergarten, Grade 1, Grade 3, and Grade 5 classes by exposing groups of Ss to either repeated failure or repeated success on hidden figures problems.
Blackwell, Janette +3 more
core +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
ISPRS International Journal of Geo-InformationThe COVID-19 outbreak followed by the strict citywide lockdown in Shanghai has sparked negative emotion surges on social media platforms in 2022. This research aims to investigate the spatial–temporal heterogeneity of a unique emotion (helplessness) and ...
Yuhao He +4 more
doaj +1 more source
The prevalence of dental anxiety across previous distressing experiences [PDF]
, 2010 Aims: To compare the prevalence of high dental anxiety across a variety of past distressing experiences with a previously reported Dutch sample. Method: University students from the UK (N=1024) completed an online survey containing; the Modified Dental ...
Humphris, Gerald Michael +3 more
core +1 more source