Results 61 to 70 of about 42,522 (262)

Fancy citrus, feel good: Positive judgment of citrus odor, but not the odor itself, is associated with elevated mood during experienced helplessness

Frontiers in Psychology, 2016
Aromatherapy claims that citrus essential oils exert mood lifting effects. Controlled studies, however, have yielded inconsistent results. Notably, studies so far did not control for odor pleasantness, although pleasantness is a critical determinant of ...
Matthias eHoenen, Katharina eMüller, Katharina eMüller, Bettina M. Pause, Katrin T. Lübke   +4 more
doaj   +1 more source

Helpless Wishful Thinking [PDF]

Deutsches Ärzteblatt international, 2016
I wish to criticize the fact that wound irrigation with infusion catheters or button cannulas, which are inserted into the full depth of the bite wound in order to remove foreign bodies and pathogens (1) is described as an apparently common method and in such a neutral fashion. Only “irrigation under pressure is inadvisable”.
openaire   +2 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Mentors' resources and premature match closure in challenging contexts: testing a model of mediating processes in an online and a school-based mentoring program

Frontiers in Psychology
IntroductionThis research aimed to investigate the impact of mentors' resources on the premature termination of mentoring relationships in challenging contexts as well as mediating psychological processes.MethodIn two studies, we analyzed the data of 98 ...
Sonja Bayer, Heidrun Stoeger, Albert Ziegler   +2 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Specifics of Relationship Between Stress and Helplessness in Adolescence

Теоретическая и экспериментальная психология
Background. The article considers the problem of helplessness and its contribution to the experience of everyday and traumatic stress. The relevance of the analysis of psychological aspects of helplessness is due to its currently ambiguous ...
Natalya E. Kharlamenkova
doaj   +1 more source

The Effectiveness of Interpersonal Psychotherapy on Generalized Anxiety and Helplessness Due to Complicated Grief in Female Survivors of COVID-19 Deaths [PDF]

مجله علوم پزشکی صدرا
Introduction: This present study aimed to investigate the effectiveness of interpersonal psychotherapy (IPT) in reducing generalized anxiety and helplessness resulting from complicated grief in female survivors of COVID-19 victims.
Elham Mohammad Barzi, Roghayeh Kiyani
doaj   +1 more source