Results 51 to 60 of about 40,335 (261)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Learned helplessness and learned controllability: from neurobiology to cognitive, emotional and behavioral neurosciences

Frontiers in Psychiatry
The sustained and prolonged exposure to environmental stressors may provoke different reactions, depending on the subjective perception of control. Repeated perception of lack of control may lead to learned helplessness, which has been linked to the ...
Gustavo E. Tafet, Tomas Ortiz Alonso
doaj   +1 more source

Trato y maltrato: una mirada psicoanalítica

Cuestiones de Género: de la Igualdad y la Diferencia, 2008
Veremos las razones por las que tratamientos con maltratadas fracasan. Repasaremos con Freud el devenir mujer: el desamparo radical del ser humano —la Hilflosighkeit freudiana— tiene connotaciones de cataclismo para las mujeres, y con él se confrontan ...
María Cruz Estada
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

FEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

Psychosocial Problems of Thalassemic in A Tertiary Care Centre, Indore

National Journal of Community Medicine, 2016
Introduction: Chronicity of thalassemia is a powerful source of emotional problems. During adolescence and young adulthood various complications may occur and patient under goes a period of psychological readjustment. Material and Methods: This was a
Sameer Inamdar, Anila Gangrade
doaj  

Helplessness in chronic obstructive pulmonary disease patients: Assessment and correlation with sociodemographic factors and spirometry-based severity

Indian Journal of Respiratory Care, 2018
Introduction: Mortality attributable to chronic obstructive pulmonary disease (COPD) in India is estimated to be among the highest in the world. Although identification and management of symptoms and signs of chronic lung diseases have improved, the ...
Akshee Batra, Garvit Chhabra, Pradeep Kumar Gupta   +2 more
doaj   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Fancy citrus, feel good: Positive judgment of citrus odor, but not the odor itself, is associated with elevated mood during experienced helplessness

Frontiers in Psychology, 2016
Aromatherapy claims that citrus essential oils exert mood lifting effects. Controlled studies, however, have yielded inconsistent results. Notably, studies so far did not control for odor pleasantness, although pleasantness is a critical determinant of ...
Matthias eHoenen, Katharina eMüller, Katharina eMüller, Bettina M. Pause, Katrin T. Lübke   +4 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source