Results 71 to 80 of about 52,296 (305)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Learned helplessness and learned controllability: from neurobiology to cognitive, emotional and behavioral neurosciences

Frontiers in Psychiatry
The sustained and prolonged exposure to environmental stressors may provoke different reactions, depending on the subjective perception of control. Repeated perception of lack of control may lead to learned helplessness, which has been linked to the ...
Gustavo E. Tafet, Tomas Ortiz Alonso
doaj   +1 more source

Trato y maltrato: una mirada psicoanalítica

Cuestiones de Género: de la Igualdad y la Diferencia, 2008
Veremos las razones por las que tratamientos con maltratadas fracasan. Repasaremos con Freud el devenir mujer: el desamparo radical del ser humano —la Hilflosighkeit freudiana— tiene connotaciones de cataclismo para las mujeres, y con él se confrontan ...
María Cruz Estada
doaj   +1 more source

Learned Helplessness, Giving Up [PDF]

, 2019
This paper explores the interplay between psychology and neurobiology. Does human depression relate to the concept of Learned Helplessness - first observed in animal research?
Anderson, Jesse
core  

Learned helplessness [PDF]

, 2020
U radu je opisan koncept naučene bespomoćnosti, povezani teorijski koncepti, njegova pojava u nekim od područja važnih za socijalni rad i načini na koje socijalni radnik može utjecati na ublažavanje i prevenciju naučene bespomoćnosti.
Galinec, Tamara
core  

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Secondary Analysis of Helplessness, Depressive Symptoms, and Sleep Quality on Health Status: A Moderated Mediation Analysis [PDF]

Terry A Cronan,1 Taylor L Skow,1 Lucy Ishkhanian,1 Melody Sadler,1 Kalila Wash,1 Angelina Van Dyne2 1Department of Psychology, San Diego State University, San Diego, CA, USA; 2San Diego State University/University of CA, San Diego Joint Doctoral Program ...
Van Dyne A, Cronan TA, Sadler M, Skow TL, Wash K, Ishkhanian L   +5 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Psychosocial Problems of Thalassemic in A Tertiary Care Centre, Indore

National Journal of Community Medicine, 2016
Introduction: Chronicity of thalassemia is a powerful source of emotional problems. During adolescence and young adulthood various complications may occur and patient under goes a period of psychological readjustment. Material and Methods: This was a
Sameer Inamdar, Anila Gangrade
doaj