Results 81 to 90 of about 195,584 (302)
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Dispositional Influences on Attributions Concerning Absenteeism [PDF]
, 1994 Because the degree to which absenteeism is within or beyond an employee\u27s control is a significant yet unresolved issue in the absence literature, it is important to understand the factors which influence employees\u27 attributions about the causes of
Judge, Timothy A. +1 more
core +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Indian Journal of Respiratory Care, 2018 Introduction: Mortality attributable to chronic obstructive pulmonary disease (COPD) in India is estimated to be among the highest in the world. Although identification and management of symptoms and signs of chronic lung diseases have improved, the ...
Akshee Batra +2 more
doaj +1 more source
Catastrophizing mediates the relationship between the personal belief in a just world and pain outcomes among chronic pain support group attendees [PDF]
, 2016 Health-related research suggests the belief in a just world can act as a personal resource that protects against the adverse effects of pain and illness.
A Furnham +58 more
core +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Psychosocial Problems of Thalassemic in A Tertiary Care Centre, Indore
National Journal of Community Medicine, 2016 Introduction: Chronicity of thalassemia is a powerful source of emotional problems. During adolescence and young adulthood various complications may occur and patient under goes a period of psychological readjustment. Material and Methods: This was a
Sameer Inamdar, Anila Gangrade
doaj
Development of Personality with Learned Helplessness at Different Stages of Ontogenesis
Вестник Кемеровского государственного университета, 2020 Learned helplessness was discovered by American positivists in the 1970s. There are two approaches to learned helplessness: as a phenomenon (state) and as a process.
O. V. Volkova
doaj +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source