Results 81 to 90 of about 52,296 (305)

Helplessness in chronic obstructive pulmonary disease patients: Assessment and correlation with sociodemographic factors and spirometry-based severity

Indian Journal of Respiratory Care, 2018
Introduction: Mortality attributable to chronic obstructive pulmonary disease (COPD) in India is estimated to be among the highest in the world. Although identification and management of symptoms and signs of chronic lung diseases have improved, the ...
Akshee Batra, Garvit Chhabra, Pradeep Kumar Gupta   +2 more
doaj   +1 more source

Learned Helplessness and the Self-Control Model of Depression [PDF]

, 1981
Self-reinforcement, one element of the self-control model of depression proposed by Rehm, was evaluated as to its relationship with Seligman's learned helplessness phenomenon.
Ronald H. Rozensky, Susan Kravitz, Rebecca Unger   +2 more
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Fancy citrus, feel good: Positive judgment of citrus odor, but not the odor itself, is associated with elevated mood during experienced helplessness

Frontiers in Psychology, 2016
Aromatherapy claims that citrus essential oils exert mood lifting effects. Controlled studies, however, have yielded inconsistent results. Notably, studies so far did not control for odor pleasantness, although pleasantness is a critical determinant of ...
Matthias eHoenen, Katharina eMüller, Katharina eMüller, Bettina M. Pause, Katrin T. Lübke   +4 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Effect of Learned Helplessness on Students [PDF]

, 2016
This experiment was conducted in order to see if a relationship existed between learned helplessness and students. In other words, I sought to see if enforced learned helplessness would have a negative impact on student test performance.
Moll, Alex
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Adaptation and Validation of Learned Helplessness Scale in Chinese Law School Students [PDF]

Cuiyu Lan,1 Tianshu Zhou,2,3 Yuchang Bao,4 Ruizhe Wang,5 Xinying Weng,6 Jie Su,7 Yinlin Li,8 Peijing Qiao,9 Danfeng Guo2 1Faculty of Law, Qingdao University, Qingdao, Shandong, People’s Republic of China; 2Department of Political Science, Suzhou ...
Lan C, Li Y, Wang R, Bao Y, Weng X, Zhou T, Guo D, Su J, Qiao P   +8 more
core   +1 more source

A narrative analysis of helplessness in depression [PDF]

, 2008
The transcripts of semistructured clinical interviews with forty psychiatrically hospitalized adolescents were subjected to narrative analysis in an effort to map the logic of their explanations as they spontaneously talked about helplessness experiences,
Stijn Vanheule, Hauser, Stuart T., Vanheule, Stijn, Stuart T. Hauser, Vanheule, StijnPP088010014148430000-0001-8580-5809F5E87094-F0ED-11E1-A9DE-61C894A0A6B4   +4 more
core   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source