Results 61 to 70 of about 13,921 (137)

Streamlined Synthesis and Structure–Activity Relationship Analysis of 2‐Amidothiophene‐3‐Carboxamides Targeting Influenza Polymerase PA‐PB1 Heterodimerization

ChemMedChem, Volume 21, Issue 10, 27 May 2026.
Development of a three‐step synthesis and replacement of the cycloheptyl moiety in cycloheptathiophene‐3‐carboxamide derivatives revealed how thiophene C‐5 substitutions modulate PA–PB1 inhibition, antiviral potency, and water solubility. The phenyl analog 9 delivered sub‐µM potency across multiple IV strains, while the methyl analog 5 achieved the ...
Tommaso Felicetti, Alessia Zago, Andrea Astolfi, Giuseppe Manfroni, Stefano Sabatini, Maria Letizia Barreca, Oriana Tabarrini, Arianna Loregian, Serena Massari   +8 more
wiley   +1 more source

Immunopotentiation by Natural Extracts: Mechanisms and Applications in Influenza Vaccine Adjuvant Development

Food Science &Nutrition, Volume 14, Issue 5, May 2026.
Natural Extracts as Candidate Influenza Vaccine Adjuvants. Seasonal influenza vaccines face limitations due to viral mutations and low efficacy in vulnerable populations. Traditional adjuvants often have safety or immune‐activation constraints, leading to increased interest in natural extracts from plants, marine organisms, and fungi.
Thi Len Ho, Eun‐Ju Ko
wiley   +1 more source

Structural intermediates in the low pH-induced transition of influenza hemagglutinin.

PLoS Pathogens, 2020
The hemagglutinin (HA) glycoproteins of influenza viruses play a key role in binding host cell receptors and in mediating virus-host cell membrane fusion during virus infection.
Jingjing Gao, Miao Gui, Ye Xiang
doaj   +1 more source

The Impact of Surfactant Protein‐D Gene Polymorphism on COVID‐19 Clinical Outcomes

Immunity, Inflammation and Disease, Volume 14, Issue 5, May 2026.
ABSTRACT Background COVID‐19, caused by the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), presents a broad spectrum of clinical manifestations, ranging from asymptomatic cases to severe, life‐threatening respiratory complications. Pulmonary surfactant‐associated protein D (SP‐D) is a critical component of pulmonary immune defense.
Nadia Nasirzadeh Kolsari, Azarakhsh Azaran, Roya Pirmoradi, Maryam Moradi, Roohangiz Nashibi, Shahram Jalilian   +5 more
wiley   +1 more source

SARS‐CoV‐2 Variants and Immune Evasion: Mapping the Future of Vaccine Design

Reviews in Medical Virology, Volume 36, Issue 3, May 2026.
ABSTRACT The evolutionary trajectory of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS‐CoV‐2) has progressed through several distinct phases since its zoonotic emergence, transitioning from initial human adaptation to an era of rapid antigenic drift and complex immune evasion. As of early 2026, the global landscape is dominated by highly evolved
Fatih Uzer, Fulya Erendor, Salih Sanlioglu   +2 more
wiley   +1 more source

Potential recombinant vaccine against influenza A virus based on M2e displayed on nodaviral capsid nanoparticles

International Journal of Nanomedicine, 2015
Chean Yeah Yong,1 Swee Keong Yeap,2 Kok Lian Ho,3 Abdul Rahman Omar,2,4 Wen Siang Tan1,2 1Department of Microbiology, Faculty of Biotechnology and Biomolecular Sciences, 2Institute of Bioscience, 3Department of Pathology, Faculty of Medicine and Health ...
Yong CY, Yeap SK, Ho KL, Omar AR, Tan WS
doaj  

Entry Inhibition of Influenza Viruses with High Mannose Binding Lectin ESA-2 from the Red Alga Eucheuma serra through the Recognition of Viral Hemagglutinin

Marine Drugs, 2015
Lectin sensitivity of the recent pandemic influenza A virus (H1N1-2009) was screened for 12 lectins with various carbohydrate specificity by a neutral red dye uptake assay with MDCK cells.
Yuichiro Sato, Kinjiro Morimoto, Takanori Kubo, Takemasa Sakaguchi, Akira Nishizono, Makoto Hirayama, Kanji Hori   +6 more
doaj   +1 more source

Effectiveness of Influenza Vaccines in Italy in the 2024/2025 Season: A Nationwide, Test‐Negative Design Study Based on Surveillance Records

Influenza and Other Respiratory Viruses, Volume 20, Issue 5, May 2026.
ABSTRACT The 2024/2025 influenza season in Italy was characterised by cocirculation of influenza A and B viruses. Monitoring influenza vaccine effectiveness (IVE) remains essential to guide public health policy due to antigenic shifts and varying strain circulation.
Daniel Cifo, Alberto Mateo‐Urdiales, Simona Puzelli, Marzia Facchini, Sara Piacentini, Emanuela Giombini, Benedetta Bellini, Massimo Fabiani, Patrizio Pezzotti, Paola Stefanelli, Anna Teresa Palamara, Antonino Bella, the RespiVirNet network   +12 more
wiley   +1 more source

Longitudinal Surveillance of Influenza A Virus Exposure in Wild Boars (Sus scrofa) in Spain (2015–2023): Serologic and Virologic Evidence of Subtype Infections and H5N1 Spillover Risk

Zoonoses and Public Health, Volume 73, Issue 3, Page 191-204, May 2026.
ABSTRACT Introduction Influenza A viruses (IAVs) are responsible for respiratory infections in a wide range of species, including birds, swine and humans. The role of wild boar (Sus scrofa) in IAV epidemiology remains underexplored. Here, we present a longitudinal serologic and virologic surveillance study of wild boars in Spain from 2015 to 2023 ...
Paloma Encinas, Aitor Nogales, Estela Escribano‐Romero, M. Ángeles Martín del Burgo, Jorge Ramón López‐Olvera, José Enrique Granados, Gregorio Mentaberre, Adolfo García‐Sastre, Gustavo del Real   +8 more
wiley   +1 more source

Broadly protective bispecific antibodies that simultaneously target influenza virus hemagglutinin and neuraminidase

mBio
Monoclonal antibodies (mAbs) are an attractive therapeutic platform for the prevention and treatment of influenza virus infection. There are two major glycoproteins on the influenza virion surface: hemagglutinin (HA), which is responsible for viral ...
Kevin E. Ramos, Nisreen M. A. Okba, Jessica Tan, Pooja Bandawane, Philip S. Meade, Madhumathi Loganathan, Benjamin Francis, Sergey Shulenin, Frederick W. Holtsberg, M. Javad Aman, Meagan McMahon, Florian Krammer, Jonathan R. Lai   +12 more
doaj   +1 more source