Results 71 to 80 of about 23,124 (216)

Antiviral effects and mechanism of Qi pi pill against influenza viruses

Animal Models and Experimental Medicine, EarlyView.
Qi pi pill presents anti‐influenza effect and inhibits viral replication in vitro by targeting both the viral RNA replication and the release of new viral particles. Furthermore, QPP modulates the production of proinflammatory cytokines induced by influenza infection in host cells.
Chengcheng Zhang, Jing Gao, Meiyue Dong, Carolina Q. Sacramento, Ping Li, Xiangyu Lian, Lingyuan Fan, Lijun Rong, Ruikun Du, Jingzhen Tian, Qinghua Cui   +10 more
wiley   +1 more source

Innate Sensing of Influenza A Virus Hemagglutinin Glycoproteins by the Host Endoplasmic Reticulum (ER) Stress Pathway Triggers a Potent Antiviral Response via ER-Associated Protein Degradation [PDF]

Journal of Virology, 2018
ABSTRACT Innate immunity provides an immediate defense against infection after host cells sense danger signals from microbes. Endoplasmic reticulum (ER) stress arises from accumulation of misfolded/unfolded proteins when protein load overwhelms the ER folding capacity, which activates the unfolded protein response (UPR) to restore ER ...
Dylan A. Frabutt, Bin Wang, Sana Riaz, Richard C. Schwartz, Yong-Hui Zheng   +4 more
openaire   +3 more sources

A temperature sensitive live-attenuated canine influenza virus H3N8 vaccine [PDF]

, 2017
Canine influenza is a respiratory disease of dogs caused by canine influenza virus (CIV). CIV subtypes responsible for influenza in dogs include H3N8, which originated from the transfer of H3N8 equine influenza virus to dogs; and the H3N2 CIV, which is ...
Chauché, Caroline, Huang, Kai, Martínez-Sobrido, Luis, Murcia, Pablo R., Nogales, Aitor, Parrish, Colin R., Reilly, Emma C., Rodriguez, Laura, Topham, David J.   +8 more
core   +1 more source

MARCH8 Inhibits Ebola Virus Glycoprotein, Human Immunodeficiency Virus Type 1 Envelope Glycoprotein, and Avian Influenza Virus H5N1 Hemagglutinin Maturation

mBio, 2020
Enveloped viruses express three classes of fusion proteins that are required for their entry into host cells via mediating virus and cell membrane fusion. Class I fusion proteins are produced from influenza viruses, retroviruses, Ebola viruses, and coronaviruses.
Changqing Yu, Yu Wang, Ilyas Khan, Yong Hui Zheng, Yong Hui Zheng, Iqbal Ahmad, Shuo Li, Jing Shi, Yulong Zhou, Sunan Li, Xianfeng Zhang   +10 more
openaire   +4 more sources

Gene constellation of influenza A virus reassortants with high growth phenotype prepared as seed candidates for vaccine production. [PDF]

PLoS ONE, 2011
BACKGROUND: Influenza A virus vaccines undergo yearly reformulations due to the antigenic variability of the virus caused by antigenic drift and shift.
Andrew A Fulvini, Manojkumar Ramanunninair, Jianhua Le, Barbara A Pokorny, Jennifer Minieri Arroyo, Jeanmarie Silverman, Rene Devis, Doris Bucher   +7 more
doaj   +1 more source

Immunity-induced criticality of the genotype network of influenza A (H3N2) hemagglutinin [PDF]

arXiv, 2021
Seasonal influenza kills hundreds of thousands every year, with multiple constantly-changing strains in circulation at any given time. A high mutation rate enables the influenza virus to evade recognition by the human immune system, including immunity acquired through past infection and vaccination.
arxiv  

Assembly and budding of influenza virus. [PDF]

, 2004
Influenza viruses are causative agents of an acute febrile respiratory disease called influenza (commonly known as "flu") and belong to the Orthomyxoviridae family.
Barman, Subrata, Hui, Eric Ka-Wai, Nayak, Debi P   +2 more
core  

Generation of virus-specific cytotoxic T cells in vitro II. Induction requirements with functionally inactivated virus preparations [PDF]

, 1980
Using noninfectious Sendai virus preparations after selective enzymatic digestion of either of the two viral envelope glycoproteins, it was possible to study the effect of different virion-cell membrane interactions on virus-specific cytotoxic T ...
Bosslet, Braciale, Ennis, Ertl, Ertl, Finberg, Gething, Halloran, Hapel, Homma, Hosaka, Julius, Klenk, Koszinowski, Koszinowski, Koszinowski, Levy, Palmer, Pfitzenmaier, Rosenthal, Scheid, Schrader, Shimizu, Sugamura, Sugamura, Wiktor, Zinkernagel, Zweerink   +27 more
core   +1 more source

Indirect Detection of Swine Influenza Activity in Porcine Blood Using Raman Spectroscopy and Machine Learning

Journal of Biophotonics, EarlyView.
Blood serum from healthy swine, unvaccinated or vaccinated against porcine reproductive and respiratory syndrome, and vaccinated swine infected with H1N1 and H1N2 variants of swine influenza was analyzed using Raman spectroscopy. Partial least squares discriminant analysis and eXtreme gradient boosting discriminant analysis of the acquired spectra ...
Aidan Paul Holman, Axell Rodriguez, Ragd Elsaigh, Roa Elsaigh, Joseph Wilson, Matt H. Cohran, Dmitry Kurouski   +6 more
wiley   +1 more source

The Antiviral Activity of Polyphenols

Molecular Nutrition &Food Research, EarlyView.
Polyphenols demonstrate remarkable antiviral properties by effectively disrupting multiple biochemical processes essential for viral replication. ABSTRACT Polyphenols are secondary metabolites produced by a large variety of plants. These compounds that comprise the class of phenolic acids, stilbenes, lignans, coumarins, flavonoids, and tannins have a ...
Markus Burkard, Alban Piotrowsky, Christian Leischner, Katja Detert, Sascha Venturelli, Luigi Marongiu   +5 more
wiley   +1 more source