Results 81 to 90 of about 13,620 (172)

A single cycle influenza virus coated in H7 hemagglutinin provides heterotypic protection and neutralising antibody responses to both glycoproteins

, 2017
AbstractA non-replicating form of pseudotyped influenza virus, inactivated by suppression of the hemagglutinin signal sequence (S-FLU), can act as a broadly protective vaccine. S-FLU can infect for a single round only, and induces heterotypic protection predominantly through activation of cross-reactive T cells in the lung.
Powell, Timothy J, Rijal, Pramila, McEwen-Smith, Rosanna M, Byun, Haewon, Hardwick, Marc, Schimanski, Lisa M, Huang, Kuan-Ying A, Daniels, Rodney S, Townsend, Alain R M   +8 more
openaire   +2 more sources

Broadly protective bispecific antibodies that simultaneously target influenza virus hemagglutinin and neuraminidase

mBio
Monoclonal antibodies (mAbs) are an attractive therapeutic platform for the prevention and treatment of influenza virus infection. There are two major glycoproteins on the influenza virion surface: hemagglutinin (HA), which is responsible for viral ...
Kevin E. Ramos, Nisreen M. A. Okba, Jessica Tan, Pooja Bandawane, Philip S. Meade, Madhumathi Loganathan, Benjamin Francis, Sergey Shulenin, Frederick W. Holtsberg, M. Javad Aman, Meagan McMahon, Florian Krammer, Jonathan R. Lai   +12 more
doaj   +1 more source

Reconstruction of H3N2 influenza virus based virosome in-vitro

Iranian Journal of Microbiology, 2013
Background and Objectives: Virosomes are Virus Like Particles (VLP) assembled in-vitro. Influenza virosomes maintain the cell binding and membrane fusion activity of the wild type virus but are devoid of viral genetic material or internal proteins ...
Asghar Abdoli, Hoorieh Soleimanjahi, Masoumeh-Tavassoti Kheiri, Abbas Jamali, Hesam Sohani, Mohsen Abdoli, Hamid Reza Rahmatollahi   +6 more
doaj  

Antibody contributes to heterosubtypic protection against influenza A-induced tachypnea in cotton rats

Virology Journal, 2008
Background Influenza virus infection or vaccination evokes an antibody response to viral hemagglutinin (HA) and neuraminidase (NA) surface glycoproteins, which results in immunity against influenza A viruses of the same HA and NA subtype.
Ottolini Martin G, Straight Timothy M, Prince Gregory A, Eichelberger Maryna C   +3 more
doaj   +1 more source

The role of stearate attachment to the hemagglutinin-esterase-fusion glycoprotein HEF of influenza C virus.

Cellular microbiology, 2016
The only spike of influenza C virus, the hemagglutinin-esterase-fusion glycoprotein (HEF) combines receptor binding, receptor hydrolysis and membrane fusion activities. Like other hemagglutinating glycoproteins of influenza viruses HEF is S-acylated, but only with stearic acid at a single cysteine located at the cytosol-facing end of the transmembrane ...
Mingyang, Wang, Kai, Ludwig, Christoph, Böttcher, Michael, Veit   +3 more
openaire   +1 more source

Identification of Low- and High-Impact Hemagglutinin Amino Acid Substitutions That Drive Antigenic Drift of Influenza A(H1N1) Viruses.

PLoS Pathogens, 2016
Determining phenotype from genetic data is a fundamental challenge. Identification of emerging antigenic variants among circulating influenza viruses is critical to the vaccine virus selection process, with vaccine effectiveness maximized when ...
William T Harvey, Donald J Benton, Victoria Gregory, James P J Hall, Rodney S Daniels, Trevor Bedford, Daniel T Haydon, Alan J Hay, John W McCauley, Richard Reeve   +9 more
doaj   +1 more source

Dynamic Viral Glycoprotein Machines: Approaches for Probing Transient States That Drive Membrane Fusion

Viruses, 2016
The fusion glycoproteins that decorate the surface of enveloped viruses undergo dramatic conformational changes in the course of engaging with target cells through receptor interactions and during cell entry.
Natalie K. Garcia, Kelly K. Lee
doaj   +1 more source

Cross-neutralization of Influenza A by SARS-CoV-2 specific neutralizing antibodies and polyclonal plasma: Is pre-exposure to SARS-CoV-2 protective against Influenza A?

Heliyon
According to sparse information from various countries, the seasonal influenza virus circulation has drastically decreased during the COVID-19 pandemic. Here, we show the cross-reactivity of anti-SARS-CoV-2 antibodies against influenza viruses.
Mohammad Mamun Alam, Asma Salauddin, Sayra Moni, Md Belayet Hasan Limon, Raisha Musarrat, Sagar Bosu, Mohammad Enayet Hossain, Mohammed Ziaur Rahman, Mustafizur Rahman   +8 more
doaj   +1 more source

Low levels of influenza H5N1 HA and NA antibodies in the human population are boosted by seasonal H1N1 infection but not by H3N2 infection or influenza vaccination

mBio
An increase in the number of human cases of influenza A/H5N1 infection in the USA has raised concerns about the pandemic potential of the virus. Pre-existing population immunity is a key determinant for risk assessment and pandemic potential for any ...
Anne P. Werner, Cosette G. Schneider, Elgin H. Akin, Juliahna Hayes, Katherine Z. J. Fenstermacher, Richard E. Rothman, Lynda Coughlan, Andrew Pekosz   +7 more
doaj   +1 more source

A monoclonal antibody specific to the HA2 glycoprotein of influenza A virus hemagglutinin that inhibits its fusion activity reduces replication of the virus.

Acta virologica, 2004
Monoclonal antibody (MAb) CF2, which binds to the fusion peptide of influenza A virus hemagglutinin (HA) (amino acids (aa) 1-35 of the N-terminus of the light chain of HA), inhibited the fusion activity of HA. This MAb preferentially bound to pH 5-treated virus (with conformationally altered HA) and bound only weakly to the native wild type (wt) virus.
E, Varecková, S A, Wharton, V, Mucha, M, Gocník, F, Kostolanský   +4 more
openaire   +1 more source