Results 131 to 140 of about 84,691 (282)

Enhancing CAR‐T Cell Efficacy in Solid Tumors by Inhibiting CCL5/VEGF‐Mediated Angiogenesis

Advanced Science, EarlyView.
This study reveals that CAR‐T cells in solid tumors produce CCL5, which paradoxically induces VEGF and angiogenesis to promote tumor growth. Blocking CCL5/VEGF signaling—through gene knockout, or the CCR5 inhibitor maraviroc—significantly enhances the antitumor efficacy of CAR‑T therapy (the diagram was created in Biorender).
Shishuo Sun, Qihong Li, Bixi Wang, Gang Wang, Ying Xue, Yibing Liang, Chenhe Hu, Zhenyu Wang, Xiaoge Gao, Haiheng Xu, Jun Song, Hailong Li, Liantao Li, Xiaoxiao Liu, Patrick Ming‐Kuen Tang, Qing Zhang   +15 more
wiley   +1 more source

Retrospective study of splenectomy specimens with clinical and pathological features in Southern Iran

Scientific Reports
The spleen is the target of numerous non-neoplastic and uncommon neoplastic lesions. Our study’s objective was to evaluate the main indications and clinicopathologic features of a large number of splenectomy specimens from southern Iran, with a focus on ...
Neda Soleimani, Mitra Soleimani, Firouze Jafari, Sahand Mohammadzadeh, Mehrdad Karajizadeh   +4 more
doaj   +1 more source

Epigenetic Effects of Benzene in Hematologic Neoplasms: The Altered Gene Expression. [PDF]

Cancers (Basel), 2021
Spatari G, Allegra A, Carrieri M, Pioggia G, Gangemi S.   +4 more
europepmc   +1 more source

Cytogenetic and hematologic characteristics of 8 cases with hematologic neoplasms and structural abnormalities of chromosome 1.

, 2013
Адрес за кореспонденция: Д-р Милена Велизарова, дм, Катедра по клинична лаборатория ***** Address for correspondence: Milena Velizarova, MD, Department of Clinical Laboratory and Clinical Immunology, Medical University – Sofi a, 1 G. Sofi yski str., tel.:
Велизарова/Velizarova, М./M., Райнов/Rainov, Ю./Y., Гигов/Gigov, И./I., Узунова/Uzunova, В./V., Митев/Mitev, Л./L., Станчев/Stanchev, Р./R.   +5 more
core  

Aptamer‐Engineered Liposomal Platform Enables in Situ cDC1 Vaccination to Potentiate Immunotherapy in Prostate Cancer

Advanced Science, EarlyView.
Prostate cancer is immunologically ‘cold’, with scarce, dysfunctional type 1 conventional dendritic cells (cDC1s) that limit T cell priming. We introduce an aptamer‐targeted liposomedelivering FMS‐like tyrosine kinase 3 ligand (Flt3L) and chlorin e6 (Ce6). Ultrasound induces antigen release and cDC1s recruitment, creating an in situ cDC1 vaccine.
Jiayi Wang, Xuan Wang, Xinfeng Dai, Linxin Tian, Wencheng Shen, Xueliang Liu, Wei Xue, Jiahua Pan, Yu Yang   +8 more
wiley   +1 more source

Immune-Mediated Cutaneous Paraneoplastic Syndromes Associated With Hematologic Malignancies: Skin as a Mirror of Hematologic Neoplasms. [PDF]

Cureus, 2021
Alvarez-Payares JC, Molina A, Gallo S, Ramirez J, Hernandez J, Lopez F, Ramirez-Urrea SI, Álvarez C.   +7 more
europepmc   +1 more source

Fungal and Viral Oral Infections in individuals with Onco-Hematologic Neoplasms in a University Hospital

ction: Individuals undergoing onco-hematologic treatment present higher risk for developing oral and/or systemic infections, due to the intense immunosuppression and compromise of the mucosal barriers during treatment.
Thaiane Dantas Dias dos Santos, Patrícia Leite Ribeiro, Renata Portela de Rezende, Davi Silva Carvalho Curi, João Frank Carvalho Dantas de Oliveira, Viviane Almeida Sarmento
core  

The Development and Pilot Clinical Study of CD147 Targeted Antagonistic Peptide Probe for Tumor Imaging

Advanced Science, EarlyView.
This study establishes [68Ga]Ga‐DOTA‐AP9 as a first‐in‐human CD147‐targeted PET tracer with favorable safety and specific tumor uptake. Tracer accumulation correlates with CD147 expression in patients, enabling noninvasive quantification of CD147‐positive malignancies.
Xiaokun Ma, Rui Guo, Dongfeng Niu, Yufei Song, Zhenyao Zhang, Xiangxi Meng, Lili Mao, Haifeng Huang, Hua Zhu, Zhi Yang, Teli Liu   +10 more
wiley   +1 more source

Epigenetics-Associated Risk Reduction of Hematologic Neoplasms in a Nationwide Cohort Study: The Chemopreventive and Therapeutic Efficacy of Hydralazine. [PDF]

Front Oncol, 2022
Yang BH, Lin WZ, Chiang YT, Chen YC, Chung CH, Chien WC, Shiau CY.   +6 more
europepmc   +1 more source

Harnessing MDM2‐Mediated Targeted Degradation of Transcriptional and Epigenetic Machinery to Disrupt Oncogenic Addictions in Pediatric Sarcoma

Advanced Science, EarlyView.
MDM2 dependency in pediatric sarcomas is driven by a novel p53‐independent oncogenic cistrome alongside canonical p53 pathway suppression. This study introduces MDM2‐recruiting transcriptional and epigenetic machinery degraders (MDM2‐TEMADs) as a novel precision oncology modality.
Jiawei Zhou, Xian Guan, Nan Li, Ying Zhang, Long Xie, Xingze Huang, Zhipeng Zhu, Zhuolin Ren, Xiaoyan Yu, Hanjun Guo, Yuanfang Wu, Lin Ma, Suya Zheng, Jingyao Zhang, Jiyang Liu, Victor Kuanmin Lee, Wenhao Chen, H. Phillip Koeffler, Jinhu Wang, Xin Han, Ye Chen, Liang Xu   +21 more
wiley   +1 more source