Results 1 to 10 of about 197,693 (253)
Donor Clonal Hematopoiesis and Recipient Outcomes After Transplantation [PDF]
medRxiv, 2021 PURPOSE Clonal hematopoiesis (CH) can be transmitted from a donor to a recipient during allogeneic hematopoietic cell transplantation. Exclusion of candidate donors with CH is controversial since its impact on recipient outcomes and graft alloimmune ...
Christopher J. Gibson +28 more
openalex +2 more sources
Nature Genetics, 2022 Clonal hematopoiesis (CH), the clonal expansion of a blood stem cell and its progeny driven by somatic driver mutations, affects over a third of people, yet remains poorly understood.
Siddhartha P Kar +2 more
exaly +2 more sources
Cancer therapy shapes the fitness landscape of clonal hematopoiesis
Nature Genetics, 2020 Acquired mutations are pervasive across normal tissues. However, understanding of the processes that drive transformation of certain clones to cancer is limited.
Kelly L Bolton +2 more
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Clonal hematopoiesis in human aging and disease
Science, 2019 Cryptic signs of aging in our blood Time is not a friend to our DNA. Aging is associated with an accumulation of somatic mutations in normal dividing cells, including the hematopoietic stem cells (HSCs) that give rise to all blood cells.
Siddhartha Jaiswal, Benjamin L Ebert
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Cardiovascular Disease, Aging, and Clonal Hematopoiesis
Annual Review of Pathology: Mechanisms of Disease, 2020 Traditional risk factors are incompletely predictive of cardiovascular disease development, a leading cause of death in the elderly. Recent epidemiological studies have shown that human aging is associated with an increased frequency of somatic mutations
Soichi Sano, Kenneth Walsh
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Distinction of lymphoid and myeloid clonal hematopoiesis
Nature Medicine, 2021 Abhishek Niroula +2 more
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Age-Related Clonal Hematopoiesis Associated with Adverse Outcomes
New England Journal of Medicine, 2014 Siddhartha Jaiswal +2 more
exaly +2 more sources
Clonal hematopoiesis of indeterminate potential and its distinction from myelodysplastic syndromes
Blood, 2015 Rafael Bejar +2 more
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Spectrum of clonal hematopoiesis in VEXAS syndrome.
Blood, 2023 VEXAS is caused by somatic mutations in UBA1 (UBA1mut) and characterized by heterogenous systemic auto-inflammation and progressive hematologic manifestations, meeting criteria for myelodysplastic syndrome (MDS) and plasma cell dyscrasias.
Fernanda Gutierrez-Rodrigues +35 more
semanticscholar +1 more source
CD14+ monocytes repress gamma globin expression at early stages of erythropoiesis
Scientific Reports, 2021 In β-hemoglobinopathies, reactivation of gamma- at the expense of beta-globin is a prominent therapeutic option. Expression of the globin genes is not strictly intrinsically regulated during erythropoiesis, supported by the observation that fetal ...
Steven Heshusius +3 more
doaj +1 more source