Results 1 to 10 of about 132,703 (360)

A case of intrathoracic extramedullary hematopoiesis-associated pleural effusion in a beta-thalassemia intermedia patient and a short literature review [PDF]

SAGE Open Medical Case Reports
Extramedullary hematopoiesis is a phenomenon that occurs in conditions of ineffective bone marrow function. In the context of thalassemias, extramedullary hematopoiesis is more frequently observed in beta-thalassemia intermedia patients, with thoracic ...
Georgios Petros Barakos, Athanasia Papazafiropoulou, Konstantinos Mihos, Valeria Eminidou, Stefani Andronikou, Lemonia Ainalidou, Niki Mofori, Themis Gkraikou, Georgios Athanasakis, Nikolaos Papanas, Stavros Antonopoulos   +10 more
doaj   +2 more sources

CD14+ monocytes repress gamma globin expression at early stages of erythropoiesis

Scientific Reports, 2021
In β-hemoglobinopathies, reactivation of gamma- at the expense of beta-globin is a prominent therapeutic option. Expression of the globin genes is not strictly intrinsically regulated during erythropoiesis, supported by the observation that fetal ...
Steven Heshusius, Esther Heideveld, Marieke von Lindern, Emile van den Akker   +3 more
doaj   +1 more source

A Plethora of Functions Condensed into Tiny Phospholipids: The Story of PI4P and PI(4,5)P₂

Cells, 2023
Phosphoinositides (PIs) are small, phosphorylated lipids that serve many functions in the cell. They regulate endo- and exocytosis, vesicular trafficking, actin reorganization, and cell mobility, and they act as signaling molecules. The most abundant PIs
Ana Bura, Sara Čabrijan, Iris Đurić, Tea Bruketa, Antonija Jurak Begonja   +4 more
doaj   +1 more source

CAISC: A software to integrate copy number variations and single nucleotide mutations for genetic heterogeneity profiling and subclone detection by single-cell RNA sequencing

BMC Bioinformatics, 2022
Background Although both copy number variations (CNVs) and single nucleotide variations (SNVs) detected by single-cell RNA sequencing (scRNA-seq) are used to study intratumor heterogeneity and detect clonal groups, a software that integrates these two ...
Jeerthi Kannan, Liza Mathews, Zhijie Wu, Neal S. Young, Shouguo Gao   +4 more
doaj   +1 more source

The oncogenic fusion protein TAZ::CAMTA1 promotes genomic instability and senescence through hypertranscription

Communications Biology, 2023
TAZ::CAMTA1 is a fusion protein found in over 90% of Epithelioid Hemangioendothelioma (EHE), a rare vascular sarcoma with an unpredictable disease course. To date, how TAZ::CAMTA1 initiates tumour formation remains unexplained.
Emily Neil, Roberto Paredes, Oscar Pooley, Brian Rubin, Valerie Kouskoff   +4 more
doaj   +1 more source

Shikonin Induces ROS-Dependent Apoptosis Via Mitochondria Depolarization and ER Stress in Adult T Cell Leukemia/Lymphoma

Antioxidants, 2023
Adult T cell leukemia/lymphoma (ATLL) is an aggressive T-cell malignancy that develops in some elderly human T-cell leukemia virus (HTVL-1) carriers.
Piyanard Boonnate, Ryusho Kariya, Seiji Okada   +2 more
doaj   +1 more source

Iron-loaded deferiprone can support full hemoglobinization of cultured red blood cells

Scientific Reports, 2023
Iron, supplemented as iron-loaded transferrin (holotransferrin), is an essential nutrient in mammalian cell cultures, particularly for erythroid cultures.
Joan Sebastián Gallego-Murillo, Nurcan Yağcı, Eduardo Machado Pinho, Sebastian Aljoscha Wahl, Emile van den Akker, Marieke von Lindern   +5 more
doaj   +1 more source

Generation of human erythroblast-derived iPSC line using episomal reprogramming system

Stem Cell Research, 2017
Peripheral blood mononuclear cells were isolated and cultured to a pure pro-EBL population and reprogrammed using episomal plasmids. The pluripotency of transgene-free induced pluripotent stem cell (iPSC) line was verified by the expression of ...
Eszter Varga, Marten Hansen, Tatjana Wüst, Marieke von Lindern, Emile van den Akker   +4 more
doaj   +1 more source

Author Correction to: Single-cell RNA-seq reveals a concomitant delay in differentiation and cell cycle of aged hematopoietic stem cells

BMC Biology, 2021
An amendment to this paper has been published and can be accessed via the original article.
Léonard Hérault, Mathilde Poplineau, Adrien Mazuel, Nadine Platet, Élisabeth Remy, Estelle Duprez   +5 more
doaj   +1 more source

Single-cell RNA-seq reveals a concomitant delay in differentiation and cell cycle of aged hematopoietic stem cells

BMC Biology, 2021
Background Hematopoietic stem cells (HSCs) are the guarantor of the proper functioning of hematopoiesis due to their incredible diversity of potential.
Léonard Hérault, Mathilde Poplineau, Adrien Mazuel, Nadine Platet, Élisabeth Remy, Estelle Duprez   +5 more
doaj   +1 more source