Results 1 to 10 of about 154,498 (360)

CD14+ monocytes repress gamma globin expression at early stages of erythropoiesis

Scientific Reports, 2021
In β-hemoglobinopathies, reactivation of gamma- at the expense of beta-globin is a prominent therapeutic option. Expression of the globin genes is not strictly intrinsically regulated during erythropoiesis, supported by the observation that fetal ...
Steven Heshusius, Esther Heideveld, Marieke von Lindern, Emile van den Akker   +3 more
doaj   +1 more source

A Plethora of Functions Condensed into Tiny Phospholipids: The Story of PI4P and PI(4,5)P₂

Cells, 2023
Phosphoinositides (PIs) are small, phosphorylated lipids that serve many functions in the cell. They regulate endo- and exocytosis, vesicular trafficking, actin reorganization, and cell mobility, and they act as signaling molecules. The most abundant PIs
Ana Bura, Sara Čabrijan, Iris Đurić, Tea Bruketa, Antonija Jurak Begonja   +4 more
doaj   +1 more source

CAISC: A software to integrate copy number variations and single nucleotide mutations for genetic heterogeneity profiling and subclone detection by single-cell RNA sequencing

BMC Bioinformatics, 2022
Background Although both copy number variations (CNVs) and single nucleotide variations (SNVs) detected by single-cell RNA sequencing (scRNA-seq) are used to study intratumor heterogeneity and detect clonal groups, a software that integrates these two ...
Jeerthi Kannan, Liza Mathews, Zhijie Wu, Neal S. Young, Shouguo Gao   +4 more
doaj   +1 more source

The oncogenic fusion protein TAZ::CAMTA1 promotes genomic instability and senescence through hypertranscription

Communications Biology, 2023
TAZ::CAMTA1 is a fusion protein found in over 90% of Epithelioid Hemangioendothelioma (EHE), a rare vascular sarcoma with an unpredictable disease course. To date, how TAZ::CAMTA1 initiates tumour formation remains unexplained.
Emily Neil, Roberto Paredes, Oscar Pooley, Brian Rubin, Valerie Kouskoff   +4 more
doaj   +1 more source

Induction of apoptosis by Shikonin through ROS-mediated intrinsic and extrinsic apoptotic pathways in primary effusion lymphoma

Translational Oncology, 2021
Primary effusion lymphoma (PEL) is an incurable non-Hodgkin's lymphoma and novel biology-based treatments are urgently needed in clinical settings. Shikonin (SHK), a napthoquinone derivative, has been used for the treatment of solid tumors.
Md Masud Alam, Ryusho Kariya, Piyanard Boonnate, Azusa Kawaguchi, Seiji Okada   +4 more
doaj   +1 more source

Iron-loaded deferiprone can support full hemoglobinization of cultured red blood cells

Scientific Reports, 2023
Iron, supplemented as iron-loaded transferrin (holotransferrin), is an essential nutrient in mammalian cell cultures, particularly for erythroid cultures.
Joan Sebastián Gallego-Murillo, Nurcan Yağcı, Eduardo Machado Pinho, Sebastian Aljoscha Wahl, Emile van den Akker, Marieke von Lindern   +5 more
doaj   +1 more source

Shikonin Induces ROS-Dependent Apoptosis Via Mitochondria Depolarization and ER Stress in Adult T Cell Leukemia/Lymphoma

Antioxidants, 2023
Adult T cell leukemia/lymphoma (ATLL) is an aggressive T-cell malignancy that develops in some elderly human T-cell leukemia virus (HTVL-1) carriers.
Piyanard Boonnate, Ryusho Kariya, Seiji Okada   +2 more
doaj   +1 more source

Optimal experimental design for mathematical models of haematopoiesis. [PDF]

, 2021
The haematopoietic system has a highly regulated and complex structure in which cells are organized to successfully create and maintain new blood cells.
Iniguez, Abdon, Jena, Nilamani, Lander, Arthur D, Liu, Zhong-Ying, Lomeli, Luis Martinez, Lowengrub, John S, Minin, Vladimir N, Shahbaba, Babak, Tata, Prasanthi, Van Etten, Richard   +9 more
core   +1 more source

The Differentiation Balance of Bone Marrow Mesenchymal Stem Cells Is Crucial to Hematopoiesis. [PDF]

, 2018
Bone marrow mesenchymal stem cells (BMSCs), the important component and regulator of bone marrow microenvironment, give rise to hematopoietic-supporting stromal cells and form hematopoietic niches for hematopoietic stem cells (HSCs).
Li, Shengwen Calvin, Li, Zhongjun, Ran, Qian, Wu, Jiang, Xiang, Yang, Zhang, Weiwei, Zhong, Jiang F   +6 more
core   +2 more sources

Generation of human erythroblast-derived iPSC line using episomal reprogramming system

Stem Cell Research, 2017
Peripheral blood mononuclear cells were isolated and cultured to a pure pro-EBL population and reprogrammed using episomal plasmids. The pluripotency of transgene-free induced pluripotent stem cell (iPSC) line was verified by the expression of ...
Eszter Varga, Marten Hansen, Tatjana Wüst, Marieke von Lindern, Emile van den Akker   +4 more
doaj   +1 more source