Results 1 to 10 of about 123,085 (346)
Journal of Allergy and Clinical Immunology, 1994 Cellular turnover of the hematopoietic system is supported by a small population of cells termed hematopoietic stem cells. Stem cells are capable of self-renewal and differentiation into individual lymphomyeloid lineages. Available evidence indicates that the decision of a stem cell to self-renew or differentiate and the decision of a multipotential ...
Makio Ogawa
openalex +3 more sources
Causes and Consequences of Clonal Hematopoiesis.
Blood, 2023 Clonal hematopoiesis (CH) describes the outsized contribution of expanded clones of hematopoietic stem and progenitor cells (HSPCs) to blood cell production. The prevalence of CH increases dramatically with age.
L. Weeks, Benjamin L. Ebert
semanticscholar +1 more source
Nature Genetics, 2022 Clonal hematopoiesis (CH), the clonal expansion of a blood stem cell and its progeny driven by somatic driver mutations, affects over a third of people, yet remains poorly understood.
S. Kar +13 more
semanticscholar +1 more source
Trends in Immunology, 2021 Hematopoiesis is a dynamic process in which stem and progenitor cells give rise to the ~1013 blood and immune cells distributed throughout the human body. We argue that a quantitative description of hematopoiesis can help consolidate existing data, identify knowledge gaps, and generate new hypotheses.
Cosgrove, Jason +3 more
openaire +4 more sources
CD14+ monocytes repress gamma globin expression at early stages of erythropoiesis
Scientific Reports, 2021 In β-hemoglobinopathies, reactivation of gamma- at the expense of beta-globin is a prominent therapeutic option. Expression of the globin genes is not strictly intrinsically regulated during erythropoiesis, supported by the observation that fetal ...
Steven Heshusius +3 more
doaj +1 more source
Cold Spring Harbor Perspectives in Biology, 2012 Enormous numbers of adult blood cells are constantly regenerated throughout life from hematopoietic stem cells through a series of progenitor stages. Accessibility, robust functional assays, well-established prospective isolation, and successful clinical application made hematopoiesis the classical mammalian stem cell system. Most of the basic concepts
Rieger, M., Schroeder, T.
openaire +3 more sources
Development, 2013 Hematopoiesis – the process by which blood cells are formed – has been studied intensely for over a century using a variety of model systems. There is conservation of the overall hematopoietic process between vertebrates, although some differences do exist.
Madhumita, Jagannathan-Bogdan +1 more
openaire +4 more sources
Prediction of Risk for Myeloid Malignancy in Clonal Hematopoiesis
Blood, 2022 BACKGROUND Clonal hematopoiesis of indeterminate potential (CHIP) and clonal cyto-penia of undetermined signi fi cance (CCUS) are de fi ned by somatic mutations in genes associated with myeloid neoplasms (MN) at a variant allele fraction (VAF) of 0.02 or ...
L. Weeks +17 more
semanticscholar +1 more source
BMC Bioinformatics, 2022 Background Although both copy number variations (CNVs) and single nucleotide variations (SNVs) detected by single-cell RNA sequencing (scRNA-seq) are used to study intratumor heterogeneity and detect clonal groups, a software that integrates these two ...
Jeerthi Kannan +4 more
doaj +1 more source