Results 1 to 10 of about 187,916 (412)
On the existence and exponential attractivity of a unique positive almost periodic solution to an impulsive hematopoiesis model with delays [PDF]
Acta Math Vietnam 41 (2016) 337-354, 2015 In this paper, a generalized model of hematopoiesis with delays and impulses is considered. By employing the contraction mapping principle and a novel type of impulsive delay inequality, we prove the existence of a unique positive almost periodic solution of the model.
Anh, Trinh Tuan +2 more
arxiv +3 more sources
Modelling hematopoiesis mediated by growth factors with applications to periodic hematological diseases [PDF]
Bulletin of Mathematical Biology 68, 8 (2006) 2321-2351, 2009 Hematopoiesis is a complex biological process that leads to the production and regulation of blood cells. It is based upon differentiation of stem cells under the action of growth factors. A mathematical approach of this process is proposed to carry out explanation on some blood diseases, characterized by oscillations in circulating blood cells.
Adimy, Mostafa +2 more
arxiv +8 more sources
Bayesian inference and model choice in a hidden stochastic two-compartment model of hematopoietic stem cell fate decisions [PDF]
Annals of Applied Statistics 2009, Vol. 3, No. 4, 1695-1709, 2010 Despite rapid advances in experimental cell biology, the in vivo behavior of hematopoietic stem cells (HSC) cannot be directly observed and measured. Previously we modeled feline hematopoiesis using a two-compartment hidden Markov process that had birth and emigration events in the first compartment.
Abkowitz, Janis +2 more
arxiv +3 more sources
Efficient Transition Probability Computation for Continuous-Time Branching Processes via Compressed Sensing [PDF]
arXiv, 2015 Branching processes are a class of continuous-time Markov chains (CTMCs) with ubiquitous applications. A general difficulty in statistical inference under partially observed CTMC models arises in computing transition probabilities when the discrete state space is large or uncountable.
Minin, Vladimir N., Xu, Jason
arxiv +4 more sources
Causes and Consequences of Clonal Hematopoiesis.
Blood, 2023 Clonal hematopoiesis (CH) describes the outsized contribution of expanded clones of hematopoietic stem and progenitor cells (HSPCs) to blood cell production. The prevalence of CH increases dramatically with age.
L. Weeks, Benjamin L. Ebert
semanticscholar +1 more source
Nature Genetics, 2022 Clonal hematopoiesis (CH), the clonal expansion of a blood stem cell and its progeny driven by somatic driver mutations, affects over a third of people, yet remains poorly understood.
S. Kar +13 more
semanticscholar +1 more source
Development, 2013 Hematopoiesis – the process by which blood cells are formed – has been studied intensely for over a century using a variety of model systems. There is conservation of the overall hematopoietic process between vertebrates, although some differences do exist.
Madhumita, Jagannathan-Bogdan +1 more
openaire +4 more sources
CD14+ monocytes repress gamma globin expression at early stages of erythropoiesis
Scientific Reports, 2021 In β-hemoglobinopathies, reactivation of gamma- at the expense of beta-globin is a prominent therapeutic option. Expression of the globin genes is not strictly intrinsically regulated during erythropoiesis, supported by the observation that fetal ...
Steven Heshusius +3 more
doaj +1 more source
Cold Spring Harbor Perspectives in Biology, 2012 Enormous numbers of adult blood cells are constantly regenerated throughout life from hematopoietic stem cells through a series of progenitor stages. Accessibility, robust functional assays, well-established prospective isolation, and successful clinical application made hematopoiesis the classical mammalian stem cell system. Most of the basic concepts
Rieger, M., Schroeder, T.
openaire +3 more sources
Prediction of Risk for Myeloid Malignancy in Clonal Hematopoiesis
Blood, 2022 BACKGROUND Clonal hematopoiesis of indeterminate potential (CHIP) and clonal cyto-penia of undetermined signi fi cance (CCUS) are de fi ned by somatic mutations in genes associated with myeloid neoplasms (MN) at a variant allele fraction (VAF) of 0.02 or ...
L. Weeks +17 more
semanticscholar +1 more source