Results 31 to 40 of about 102,104 (304)

CSF1R regulates the dendritic cell pool size in adult mice via embryo-derived tissue-resident macrophages

Nature Communications, 2018
Dendritic cells (DC) are important regulators of both innate and adaptive immunity, but how the DC pool is homeostatically maintained in vivo is unclear.
Gulce Itir Percin, Jiri Eitler, Andrea Kranz, Jun Fu, Jeffrey W. Pollard, Ronald Naumann, Claudia Waskow   +6 more
doaj   +1 more source

Single-cell RNA-seq reveals a concomitant delay in differentiation and cell cycle of aged hematopoietic stem cells

BMC Biology, 2021
Background Hematopoietic stem cells (HSCs) are the guarantor of the proper functioning of hematopoiesis due to their incredible diversity of potential.
Léonard Hérault, Mathilde Poplineau, Adrien Mazuel, Nadine Platet, Élisabeth Remy, Estelle Duprez   +5 more
doaj   +1 more source

Interferons in hematopoiesis and leukemia [PDF]

, 2013
Interferons not only exert a fundamental role during inflammation and immune responses but also modulate the activity of hematopoietic stem cells during homeostatic and demand-adapted hematopoiesis.
Ochsenbein, Adrian F., Schürch, Christian M., Riether, Carsten   +2 more
core   +2 more sources

Clonal hematopoiesis in cancer. [PDF]

, 2020
Clonal hematopoiesis is a common premalignant condition defined by the abnormal expansion of clonally derived hematopoietic stem cells carrying somatic mutations in leukemia-associated genes.
Bejar, Rafael, Park, Soo J
core   +1 more source

Polyfunctional tumor-reactive T cells are effectively expanded from non-small cell lung cancers, and correlate with an immune-engaged T cell profile

OncoImmunology, 2019
Non-small cell lung cancer (NSCLC) is the second most prevalent type of cancer. With the current treatment regimens, the mortality rate remains high. Therefore, better therapeutic approaches are necessary.
Rosa De Groot, Marleen M. Van Loenen, Aurélie Guislain, Benoît P. Nicolet, Julian J. Freen-Van Heeren, Onno J.H.M. Verhagen, Michel M. Van Den Heuvel, Jeroen De Jong, Patrick Burger, C.Ellen Van Der Schoot, Robbert M. Spaapen, Derk Amsen, John B. A. G. Haanen, Kim Monkhorst, Koen J. Hartemink, Monika C. Wolkers   +15 more
doaj   +1 more source

CD82 expression marks the endothelium to hematopoietic transition at the onset of blood specification in human

iScience, 2023
Summary: During embryonic development, all blood progenitors are initially generated from endothelial cells that acquire a hemogenic potential. Blood progenitors emerge through an endothelial-to-hematopoietic transition regulated by the transcription ...
Sara Menegatti, Bethany Potts, Roberto Paredes, Eva Garcia-Alegria, Syed Murtuza Baker, Valerie Kouskoff   +5 more
doaj   +1 more source

The Potential of Tissue-Resident Memory T Cells for Adoptive Immunotherapy against Cancer

Cells, 2021
Tissue-resident memory T cells (TRM) comprise an important memory T cell subset that mediates local protection upon pathogen re-encounter. TRM populations preferentially localize at entry sites of pathogens, including epithelia of the skin, lungs and ...
Ammarina Beumer-Chuwonpad, Renske L. R. E. Taggenbrock, T. An Ngo, Klaas P. J. M. van Gisbergen   +3 more
doaj   +1 more source

Bone Marrow Harbors a Unique Population of Dendritic Cells with the Potential to Boost Neutrophil Formation upon Exposure to Fungal Antigen

Cells, 2021
Apart from controlling hematopoiesis, the bone marrow (BM) also serves as a secondary lymphoid organ, as it can induce naïve T cell priming by resident dendritic cells (DC).
Marieke Goedhart, Edith Slot, Maria F. Pascutti, Sulima Geerman, Timo Rademakers, Benjamin Nota, Stephan Huveneers, Jaap D. van Buul, Katherine C. MacNamara, Carlijn Voermans, Martijn A. Nolte   +10 more
doaj   +1 more source

Characterization of the Proteins HPIP and VENTX2 as Novel Regulatory Proteins of Human Hematopoiesis [PDF]

, 2006
The hallmark of hematopoietic stem cells (HSC) is their ability of self-renewal and differentiation into multiple hematopoietic cell lineages. Although the molecular network controlling stem cell fate decisions is largely unknown, multiple studies have ...
Arseni, Natalia, Arseni, N.
core   +1 more source

MEIS1 regulates early erythroid and megakaryocytic cell fate

Haematologica, 2014
MEIS1 is a transcription factor expressed in hematopoietic stem and progenitor cells and in mature megakaryocytes. This biphasic expression of MEIS1 suggests that the function of MEIS1 in stem cells is distinct from its function in lineage committed ...
Sabrina Zeddies, Sjoert B. G. Jansen, Franca di Summa, Dirk Geerts, Jaap J. Zwaginga, C. Ellen van der Schoot, Marieke von Lindern, Daphne C. Thijssen-Timmer   +7 more
doaj   +1 more source