Results 21 to 30 of about 102,104 (304)

siddhartha-kar/clonal-hematopoiesis: clonal hematopoiesis paper code repository

, 2022
This is the repository accompanying the pre-print titled, "Genome-wide analyses of 200,453 individuals yields new insights into the causes and consequences of clonal hematopoiesis" (https://www.medrxiv.org/content/10.1101/2022.01.06.22268846v1)
Siddhartha Kar
core   +1 more source

The oncogenic fusion protein TAZ::CAMTA1 promotes genomic instability and senescence through hypertranscription

Communications Biology, 2023
TAZ::CAMTA1 is a fusion protein found in over 90% of Epithelioid Hemangioendothelioma (EHE), a rare vascular sarcoma with an unpredictable disease course. To date, how TAZ::CAMTA1 initiates tumour formation remains unexplained.
Emily Neil, Roberto Paredes, Oscar Pooley, Brian Rubin, Valerie Kouskoff   +4 more
doaj   +1 more source

Induction of apoptosis by Shikonin through ROS-mediated intrinsic and extrinsic apoptotic pathways in primary effusion lymphoma

Translational Oncology, 2021
Primary effusion lymphoma (PEL) is an incurable non-Hodgkin's lymphoma and novel biology-based treatments are urgently needed in clinical settings. Shikonin (SHK), a napthoquinone derivative, has been used for the treatment of solid tumors.
Md Masud Alam, Ryusho Kariya, Piyanard Boonnate, Azusa Kawaguchi, Seiji Okada   +4 more
doaj   +1 more source

Clonal hematopoiesis [PDF]

Seminars in Hematology, 2017
Cancer results from multistep pathogenesis, yet the pre-malignant states that precede the development of many hematologic malignancies have been difficult to identify. Recent genomic studies of blood DNA from tens of thousands of people have revealed the presence of remarkably common, age-associated somatic mutations in genes associated with ...
Max, Jan, Benjamin L, Ebert, Siddhartha, Jaiswal   +2 more
openaire   +2 more sources

Differential Hox expression in murine embryonic stem cell models of normal and malignant hematopoiesis [PDF]

, 2011
The Hox family are master transcriptional regulators of developmental processes, including hematopoiesis. The Hox regulators, caudal homeobox factors (Cdx1-4), and Meis1, along with several individual Hox proteins, are implicated in stem cell expansion ...
Glenda J. Dickson, Pamela M. Corrigan, Freeburn, R.W., Robin W. Freeburn, Dickson, Glenda, Thompson, Alexander, Ramsey, Joanne, Helen Wheadon, Wheadon, H., Dickson, G.J., Edwina Dobbin, Alexander Thompson, Ramsey, J.M., Corrigan, P.M., Joanne M. Ramsey, Dobbin, E., Thompson, A.   +16 more
core   +1 more source

Generation of human erythroblast-derived iPSC line using episomal reprogramming system

Stem Cell Research, 2017
Peripheral blood mononuclear cells were isolated and cultured to a pure pro-EBL population and reprogrammed using episomal plasmids. The pluripotency of transgene-free induced pluripotent stem cell (iPSC) line was verified by the expression of ...
Eszter Varga, Marten Hansen, Tatjana Wüst, Marieke von Lindern, Emile van den Akker   +4 more
doaj   +1 more source

Transforming growth factor-ß (TGF-ß) signaling in hematopoiesis and tumorigenesis [PDF]

, 2008
Transforming growth factor β (TGF-β) signaling regulates numerous cellular and physiological processes. Dysfunction of components of this signaling pathway leads to a wide range of diseases ranging from malignant hematopoiesis, cardiovascular disease,
Pan, Dejing
core   +1 more source

Comprehensive network modeling from single cell RNA sequencing of human and mouse reveals well conserved transcription regulation of hematopoiesis

BMC Genomics, 2020
Background Presently, there is no comprehensive analysis of the transcription regulation network in hematopoiesis. Comparison of networks arising from gene co-expression across species can facilitate an understanding of the conservation of functional ...
Shouguo Gao, Zhijie Wu, Xingmin Feng, Sachiko Kajigaya, Xujing Wang, Neal S. Young   +5 more
doaj   +1 more source

Establishment of regulatory elements during erythro-megakaryopoiesis identifies hematopoietic lineage-commitment points

Epigenetics & Chromatin, 2018
Background Enhancers and promoters are cis-acting regulatory elements associated with lineage-specific gene expression. Previous studies showed that different categories of active regulatory elements are in regions of open chromatin, and each category is
Elisabeth F. Heuston, Cheryl A. Keller, Jens Lichtenberg, Belinda Giardine, Stacie M. Anderson, NIH Intramural Sequencing Center, Ross C. Hardison, David M. Bodine   +7 more
doaj   +1 more source

Author Correction to: Single-cell RNA-seq reveals a concomitant delay in differentiation and cell cycle of aged hematopoietic stem cells

BMC Biology, 2021
An amendment to this paper has been published and can be accessed via the original article.
Léonard Hérault, Mathilde Poplineau, Adrien Mazuel, Nadine Platet, Élisabeth Remy, Estelle Duprez   +5 more
doaj   +1 more source