Results 151 to 160 of about 90,270 (303)

CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

Advanced Science, EarlyView.
CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He, Yuzhong Peng, Lat‐lun Leong, Jingbo Zhou, Dongyang Tang, Weilu Wang, Xiaoran Wu, Josh haipeng Lei, Yongqin Ye, Yangyang Feng, Yunfeng Qiao, Xiangpeng Chu, Di Mu, Qi Zhao, Tzuming Liu, Yan Chen, Paul Kwonghang Tam, Chu‐Xia Deng   +17 more
wiley   +1 more source

Memory CD8+ T cells support the maintenance of hematopoietic stem cells in the bone marrow

Haematologica, 2018
Sulima Geerman, Giso Brasser, Sudeep Bhushal, Fiamma Salerno, Natasja A. Kragten, Mark Hoogenboezem, Gerald de Haan, Monika C. Wolkers, María Fernanda Pascutti, Martijn A. Nolte   +9 more
doaj   +1 more source

Investigating the causal relationship and mediating mechanisms between Clonal hematopoiesis and vitamin D levels: A Mendelian randomization study. [PDF]

Medicine (Baltimore)
Liang C, Li M, Sun Z.
europepmc   +1 more source

Hematopoiesis in the Fetus and Neonate [PDF]

, 1989
Robert D. Christensen
openalex   +1 more source

Red Blood Cells Internalize Extracellular DNA via Apoptotic Bodies with Clinical Relevance to Cancer Patients

Advanced Science, EarlyView.
Mature red blood cells (RBCs) can capture extracellular DNA, with short fragments homologous to cfDNA. This uptake is mediated by apoptotic bodies, which induce RBC oxidative stress, deformation, and accelerated in vivo clearance. The rbcDNA abundance correlates with tumor burden and therapeutic response, highlighting its potential as a liquid biopsy ...
Zihang Zeng, Zongbi Yi, Jing Hu, Jiali Li, Yu Xu, Xiuli Guo, Qian Ji, Kaixiang Feng, Ying Zhang, Sirui Bai, Yushuang Tan, Yufei Yan, Linzhi Han, Jing Jiang, Tengfei Wang, Xiang Wang, Ziqing Zhan, Ruiying Huang, Jinfang Zhang, Conghua Xie, Binghe Xu   +20 more
wiley   +1 more source

PROGNOSIS OF ACUTE LEUKEMIA IN CHILDREN DEPENDING ON THE STAGE OF HEMATOPOIESIS AND PHASES OF CHEMOTHERAPY

, 2018
V. Bebeshko, K. M. Bruslova, T. I. Pushkareva, N. M. Tsvyetkova, L. Lyashenko, J. S. Yaroshenko, O.Ye. Kuznyetsova, L. O. Gonchar, V. M. Ivankin, О. I. Makovei   +9 more
openalex   +2 more sources

The Yin and Yang of Stem Cell Gene Therapy: Insights into Hematopoiesis, Leukemogenesis, and Gene Therapy Safety [PDF]

, 2007
Cynthia E. Dunbar
openalex   +1 more source

Supplemental Table S3 from Clonal Hematopoiesis in Young Women Treated for Breast Cancer

, 2023
Christopher J. Gibson, Geoffrey Fell, Tal Sella, Adam S. Sperling, Craig Snow, Shoshana M. Rosenberg, Gregory J. Kirkner, Ashka Patel, Deborah Dillon, Alexander G. Bick, Donna Neuberg, Ann H. Partridge, Peter G. Miller   +12 more
openalex   +1 more source

Mammalian Proteome Profiling Reveals Readers and Antireaders of Strand‐Symmetric and ‐Asymmetric 5‐Hydroxymethylcytosine‐Modifications in DNA

Advanced Science, EarlyView.
ABSTRACT The cytosine (C) modifications 5‐methylcytosine (mC) and 5‐hydroxymethylcytosine (hmC) are central regulatory elements of mammalian genomes. Both marks occur in double‐stranded DNA in either strand‐symmetric or ‐asymmetric fashion, but it is still poorly understood how this symmetry information is selectively read out by the nuclear proteome ...
Lena Engelhard, Zeyneb Vildan Cakil, Marlon S. Zambrano‐Mila, Simone Eppmann, Tye Gonzalez, Rasmus Linser, Petra Janning, Sidney Becker, Daniel Summerer   +8 more
wiley   +1 more source

Driver mutation-defined molecular landscapes of essential thrombocythemia. [PDF]

Blood Sci
Lorenzen AL, Huang G.
europepmc   +1 more source