Results 161 to 170 of about 90,270 (303)

Evolutionary perspective on the hematopoietic system through a colonial chordate: allogeneic immunity and hematopoiesis

, 2020
Benyamin Rosental, Tal Raveh, Ayelet Voskoboynik, Irving L. Weissman   +3 more
openalex   +2 more sources

Hematopoiesis: Progenitors and their genetic program [PDF]

, 1998
Françoise Dieterlen‐Lièvre
openalex   +1 more source

Data from Clonal Hematopoiesis in Young Women Treated for Breast Cancer

, 2023
Christopher J. Gibson, Geoffrey Fell, Tal Sella, Adam S. Sperling, Craig Snow, Shoshana M. Rosenberg, Gregory J. Kirkner, Ashka Patel, Deborah Dillon, Alexander G. Bick, Donna Neuberg, Ann H. Partridge, Peter G. Miller   +12 more
openalex   +1 more source

A Lung‐Immune Dual‐Humanized Mouse Using Cryopreserved Tissue Enables Infection and Immune Profiling of Human Common Cold Coronaviruses

Advanced Science, EarlyView.
Cryopreserved lung‐humanized mice overcome the dependency to fresh tissues and permit head‐to‐head profiling of all four human common cold coronaviruses versus SARS‐CoV‐2 infection; the model validates Paxlovid efficacy against HKU1 and, when coupled with human immune‐system engraftment, enables interrogation of lung‐resident human immunity and HKU1 ...
Chunyu Cheng, Jing Sun, Chun Lu, Qian Yu, Yiyun He, Bingqing Wu, Deshan Ren, Shuai Ding, Jincun Zhao, Yan Li   +9 more
wiley   +1 more source

Lineage tracing of both quiescent G0 and active Hoxb5+ LT-HSCs that actively contribute to homeostatic mouse hematopoiesis. [PDF]

Proc Natl Acad Sci U S A
Xiang J, Almeida L, Pasillas J, Sun CT, Wang Y, Koren E, Hanson EC, Brakebill A, Wang C, Burden AT, Weissman IL.   +10 more
europepmc   +1 more source

Supplementary Figure 6 from Clinical Outcomes and Evolution of Clonal Hematopoiesis in Patients with Newly Diagnosed Multiple Myeloma

, 2023
Tarek H. Mouhieddine, Chidimma Nzerem, Robert Redd, Andrew Dunford, Matthew Leventhal, Romanos Sklavenitis‐Pistofidis, Sabrin Tahri, Habib El‐Khoury, David P. Steensma, Benjamin L. Ebert, Robert J. Soiffer, Jonathan J. Keats, Shaadi Mehr, Daniel Auclair, Irene M. Ghobrial, Adam S. Sperling, Chip Stewart, Gad Getz   +17 more
openalex   +1 more source

A Microbiota‐ and IL‐15‐Dependent Innate‐Like B Cell Progenitor Expressing E4BP4

Advanced Science, EarlyView.
This work identifies CD3.NKp46.CD19.NK1.1. NK‐B cells enriched in PDK1‐deficient yet present in wild‐type bone marrow. IL‐15 (via CD122) and TLR9‐microbiota signaling maintain their E4BP4 expression. These cells demonstrate innate immunity, preferentially differentiate into B cells, and unveil a novel microbiota‐ and IL‐15‐dependent regulatory pathway ...
Junming He, Xinlei Hou, Xiaomei Feng, Yayun Dong, Mengqi Ren, Surong Deng, Xinru Yang, Donglin Chen, Lingna Zhao, Shasha Chen, Meixiang Yang, Zhongjun Dong   +11 more
wiley   +1 more source

<i>In vitro</i> derivation of megakaryocytes and platelets from induced pluripotent stem cells: developmental foundations and translational perspectives. [PDF]

Front Immunol
Mazurek M, Młynarski W, Grzela DP.
europepmc   +1 more source

Additional file 5: of Cell-free DNA profiling of metastatic prostate cancer reveals microsatellite instability, structural rearrangements and clonal hematopoiesis

, 2018
Markus Mayrhofer, Bram De Laere, Tom Whitington, Peter Van Oyen, Christophe Ghysel, J Ampe, Piet Ost, Wim Demey, Lucien Hoekx, Dirk Schrijvers, Barbara Brouwers, Willem Lybaert, Els Everaert, Daan De Maeseneer, Michiel Strijbos, Alain Bols, Karen Fransis, Steffi Oeyen, Pieter‐Jan van Dam, Gert Van den Eynden, Annemie Rutten, Markus Aly, Tobias NordstrĂśm, Steven Van Laere, Mattias Rantalainen, Prabhakar Rajan, Lars Egevad, Anders UllĂŠn, Jeffrey Yachnin, Luc Dirix, Henrik GrĂśnberg, Johan Lindberg   +31 more
openalex   +1 more source

Efferocytosis‐Driven Polyamine Metabolism in Macrophages Enhances Cancer Stem Cell Enrichment after Chemotherapy in Ovarian Cancer

Advanced Science, EarlyView.
Chemotherapy‐induced efferocytosis drives ovarian cancer stem cell enrichment. By engulfing apoptotic cancer cells, macrophages upregulate ODC1 and produce putrescine, which elevates osteopontin (OPN) expression. Secreted OPN then activates the CD44 receptor on cancer cells, promoting stemness and chemoresistance.
Wenhan Li, Feiquan Ying, Xinkai Pang, Qiulei Wu, Guoqing Li, Lin Huang, Jiayu Xin, Xiaoli Liu, Pan Liu, Xiaohan Xu, Shuran Tan, Yumei Gao, Tong Liu, Si Sun, Xiaoman Wang, Yiping Wen, Liqiong Cai, Shi Du, Yuan Zhang, Jing Cai   +19 more
wiley   +1 more source