Results 181 to 190 of about 157,726 (359)

Variations in Innate Immune Cell Subtypes Correlate with Epigenetic Clocks, Inflammaging and Health Outcomes

open access: yesAdvanced Science, EarlyView.
This study uses a high‐resolution DNA methylation reference panel for 19 immune cell‐types, as well as transcriptomic, metabolomic, and large population cohort data to show that age‐related epigenetic heterogeneity within monocytes correlates with inflammaging, biological age, and all‐causemortality, and does so more strongly than existing monocyte ...
Xiaolong Guo   +17 more
wiley   +1 more source

Lithium is an ineffective therapy for human cyclic hematopoiesis [PDF]

open access: bronze, 1983
WP Hammond   +3 more
openalex   +1 more source

Engineered crRNA Drives RPA‐T7‐CRISPR/Cas14a Cascade for Ultrasensitive Detection of ctDNA PIK3CA H1047R

open access: yesAdvanced Science, EarlyView.
The TIDE‐Cas14a system, an integrated RPA‐T7‐CRISPR/Cas14a cascade platform incorporating engineered crRNA mismatches, enables ultrasensitive detection of the PIK3CA H1047R mutation in breast cancer circulating tumor DNA, with a limit of detection as low as 0.01%, surpassing the sensitivity of droplet digital PCR.
Yuanyuan Yu   +19 more
wiley   +1 more source

Cell Fate Determination and Lineage Tracing: Technological Evolution and Multidimensional Applications

open access: yesAdvanced Science, EarlyView.
This figure is a candidate for the cover image. It shows a whole‐mount fluorescent image of lymphatic vessels (red) in the heart of an adult Cdh5‐Dre; Prox1‐RSR‐CreER; Rosa26‐tdT mouse. Image courtesy of Ximeng Han. Abstract Cell fate determination is a fundamental process in multicellular development.
Hui Chen   +3 more
wiley   +1 more source

The pathogenesis of splenic extramedullary hematopoiesis in metastatic carcinoma [PDF]

open access: bronze, 1989
J. C. O’Keane   +2 more
openalex   +1 more source

Mitochondria‐Localized Nestin Protects Mesenchymal Stem Cells from Senescence by Maintaining Cristae Structure and Function

open access: yesAdvanced Science, EarlyView.
Nestin localizes to the mitochondrial IMS through its MTS and the TOM20 import machinery. Within the mitochondria, Nestin interacts with Mic60 via its C‐terminal Tail3 domain. Loss of mitochondrial Nestin disrupts cristae architecture, leading to mitochondrial swelling, bioenergetic dysfunction, and ultimately the senescence of hMSCs.
Hainan Chen   +14 more
wiley   +1 more source

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