Results 181 to 190 of about 121,287 (371)
Advanced Science, EarlyView.A critical aspect of chromosomal remodeling in small molecule‐induced multilineage trans‐differentiation(iMT) is elucidated. A dynamic atlas spanning over 35 days profiles terminal trans‐differentiated cells, which reverted to a more youthful state. This study reveals parallels between iMT and other cell fate determination processes, emphasizing an ...
Weigao E +13 more
wiley +1 more source
Assessment of Clonal Hematopoiesis of Indeterminate Potential from Cardiac Magnetic Resonance Imaging using Deep Learning in a Cardio-oncology Population [PDF]
arXivBackground: We propose a novel method to identify who may likely have clonal hematopoiesis of indeterminate potential (CHIP), a condition characterized by the presence of somatic mutations in hematopoietic stem cells without detectable hematologic malignancy, using deep learning techniques.
arxiv
Advanced Science, EarlyView.This study uses gut microbiome data to predict corticosteroid response in patients with immune thrombocytopenia (ITP). Fecal samples from 212 patients with ITP are sequenced. Six machine‐learning algorithms are used to train predictive models. The support vector machine‐based model integrated clinical data and selected microbial species, diversities ...
Feng‐Qi Liu +38 more
wiley +1 more source
HNF3α Targets Nckap1l and Promotes Renal Fibrosis Following Ischemia‐Reperfusion Injury
Advanced Science, EarlyView.Hepatocyte Nuclear Factor 3 alpha (HNF3α) is significantly upregulated in renal tubular epithelial cells of CKD patients and fibrotic mice. Deletion of HNF3α mitigates IRI‐induced renal fibrosis, while overexpression worsens it. HNF3α directly regulates NCK‐associated protein 1‐like (Nckap1l), whose overexpression exacerbates fibrosis.
Ling Hou +7 more
wiley +1 more source
Hematopoiesis and Serum Iron Changes Following Vincristine Sulfate [PDF]
, 1969 Mark E. Nesbit, James T. Lowman
openalex +1 more source
Advanced Science, EarlyView.Hypoxic and low‐glucose conditions in tumor tissues trigger colorectal tumor cell pyroptosis via sequential activation of the Caspase‐1/Caspase‐6/GSDMC axis. High mobility group box 1 (HMGB1), released from GSDMC‐mediated pyroptotic tumor cells, upregulates CXCL2 expression in adjacent tumor cells, thereby recruiting myeloid‐derived suppressor cells ...
Hanchao Gao +11 more
wiley +1 more source
Niches that regulate stem cells and hematopoiesis in adult bone marrow.
Developmental Cell, 2021 Stefano Comazzetto, Bo Shen, S. Morrison
semanticscholar +1 more source
Advanced Science, EarlyView.NRAS mutations are widespread in hematologic malignancies. Our study shows that GOLGA7 serves as a safe and effective therapeutic target for NRAS‐driven leukemia. Loss of Golga7 in adult mice effectively suppresses NrasG12D‐driven myeloproliferative neoplasm by disrupting its PM localization and impairing subsequent MAPK signaling, without affecting ...
Bo Jiao +18 more
wiley +1 more source