Results 231 to 240 of about 121,287 (371)

Identification and Drug Screening of Single Cells from Human Tumors on Semiconductor Chip for Cancer Precision Medicine

Advanced Science, EarlyView.
The study innovatively integrates single‐cell electric impedance identification and drug screening on a semiconductor chip, addressing tumor heterogeneity limitations. The system achieves label‐free cancer cell recognition while concurrently evaluating drug efficacy on cancer cells and toxicity on noncancerous cells.
Wenhao Hui, Ka‐Meng Lei, Yingying Liu, Xinru Huang, Yunlong Zhong, Xiaojun Chen, Mingji Wei, Jie Yan, Ren Shen, Pui‐In Mak, Rui P. Martins, Shuhong Yi, Ping Wang, Yanwei Jia   +13 more
wiley   +1 more source

Transcription‐independent functions of p53 in DNA repair pathway selection

BioEssays, Volume 45, Issue 1, January 2023., 2023
Transcription‐independent early recruitment and PARylation of p53 at DNA damage sites promotes the recruitment of particular repair factors (e.g. DDB1 and 53BP1) and thereby tipping the balance of repair pathway selection. Abstract Recently discovered transcription‐independent features of p53 involve the choice of DNA damage repair pathway after ...
Yu‐Hsiu Wang, Michael P. Sheetz
wiley   +1 more source

Association between clonal hematopoiesis and periodontitis: a two-sample mendelian randomization study. [PDF]

Sci Rep
Qiu F, Shao W, Qin X, Xu R, Lu H.
europepmc   +1 more source

Antigenic analysis of hematopoiesis: II. Expression of human neutrophil antigens on normal and leukemic marrow cells [PDF]

, 1984
LC Strauss, KM Skubitz, JT August, CI Civin   +3 more
openalex   +1 more source

Targeted Penetrating Motif Engineering of BH3 Mimetic: Harnessing Non‐Canonical Amino Acids for Coinhibition of MCL‐1 and BCL‐xL in Acute Myeloid Leukemia

Advanced Science, EarlyView.
A structure‐guided peptide derived from a non‐canonical amino acid library simultaneously targets MCL‐1 and BCL‐xL to overcome apoptotic resistance in acute myeloid leukemia. Fused with a CXCR4‐binding motif, the engineered peptide exhibits selective intracellular delivery and potent in vivo efficacy, offering a promising therapeutic strategy against ...
Zhe Wang, Ruizhi Lai, Xinpei Wang, Xu Chen, Youjian Zhou, Shengbin Li, Xiaohui Qiu, Zekai Zeng, Jianye Yuan, Jinghuan Mao, Zhidong Chen, Junqing Wang   +11 more
wiley   +1 more source

Chromosomal breaks at the origin of small tandem DNA duplications

BioEssays, Volume 45, Issue 1, January 2023., 2023
Small tandem DNA duplications form a specific mutational signature frequently found in human disease alleles and cancer genes. Here we hypothesize that these duplications mainly arise at chromosomal DNA breaks that result from two closely located single‐stranded nicks, through error‐prone repair by the non‐homologous end‐joining pathway. Abstract Small
Joost Schimmel, Marloes D. van Wezel, Robin van Schendel, Marcel Tijsterman   +3 more
wiley   +1 more source

Pelvic extramedullary hematopoiesis with life-threatening hemorrhage: a case report. [PDF]

Int J Emerg Med
Habbash Z, Hassan A, Kadhem S, Mujbel N, Aljawad M.   +4 more
europepmc   +1 more source

Memory CD8+ T cells support the maintenance of hematopoietic stem cells in the bone marrow

Haematologica, 2018
Sulima Geerman, Giso Brasser, Sudeep Bhushal, Fiamma Salerno, Natasja A. Kragten, Mark Hoogenboezem, Gerald de Haan, Monika C. Wolkers, María Fernanda Pascutti, Martijn A. Nolte   +9 more
doaj   +1 more source

Extramedullary Hematopoiesis Presenting as Pleural Thickening in a Patient With Choroidal Melanoma. [PDF]

Cureus
Li S, Mubin A, Cantu D.
europepmc   +1 more source

Thymic regulation of hematopoiesis. III: Isolation of helper and suppressor populations using counterflow centrifugal elutriation [PDF]

, 1986
SJ Sharkis, C Cremo, MI Collector, SJ Noga, A.D. Donnenberg   +4 more
openalex   +1 more source