Results 251 to 260 of about 157,726 (359)

A Dual‐Target Recognition System Based on Acid‐Degradable Ni‐MOF and Aptamer Guidance for Precise Tumor Diagnosis and Combined Therapy

open access: yesAdvanced Science, EarlyView.
This work reports a Ni‐doped ZIF‐8 nanoplatform co‐encapsulating glucose oxidase and horseradish peroxidase, enabling a cascade catalytic reaction that produces hydroxyl radicals from endogenous glucose and hydrogen peroxide. Upon near‐infrared irradiation, the system simultaneously achieves photothermal and chemodynamic therapy, offering an effective ...
Jing Xu   +8 more
wiley   +1 more source

Remethylation of Dnmt3a−/− hematopoietic cells is associated with partial correction of gene dysregulation and reduced myeloid skewing [PDF]

open access: yes, 2020
Bangert, Celia V.   +17 more
core   +1 more source

Bone Marrow Mesenchymal Stem Cell Hydrogel‐Mediated Fibroblast Reprogramming Restores Intestinal Function in Adhesive Small Bowel Obstruction

open access: yesAdvanced Science, EarlyView.
Conceptual diagram and schematic illustration of microenvironmental changes in individuals with ASBO before and after treatment. BMSC@Gel therapy transforms the ASBO microenvironment from an inflammatory, fibrotic state with aberrant matrix deposition and barrier dysfunction to a regenerative state with reduced inflammation and improved structural ...
Lihong Zheng *   +7 more
wiley   +1 more source

AP2M1 Amplification Orchestrates Notch‐Mediated Chemoresistance in Hematopoietic Stem Cells of Acute Myeloid Leukemia Patients

open access: yesAdvanced Science, EarlyView.
The precise regulation of AP2M1 is essential for normal hematopoiesis. Overexpression of AP2M1 negatively affects the clinical outcomes of AML patients. Upregulation of AP2M1 enhances stemness and chemoresistance in HSPC cells of AML. AP2M1 modulates NOTCH1 expression, enhancing the Notch1 signaling pathway.
Hansong Lee   +28 more
wiley   +1 more source

Retraction of Sorting protein VPS33B regulates exosomal autocrine signaling to mediate hematopoiesis and leukemogenesis. [PDF]

open access: yesJ Clin Invest
Gu H   +24 more
europepmc   +1 more source

Identifying Key Questions and Challenges in Microchimerism Biology

open access: yesAdvanced Science, EarlyView.
This study identifies key unanswered questions about microchimerism, the presence of cells from one individual living in another. Experts highlight how these cells may affect health, pregnancy, and disease. This study outlines research priorities and challenges in detecting and studying these rare microchimeric cells, aiming to guide future discoveries
Kristine J. Chua   +31 more
wiley   +1 more source

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