Results 111 to 120 of about 469,315 (359)

An All-Recombinant Protein-Based Culture System Specifically Identifies Hematopoietic Stem Cell Maintenance Factors. [PDF]

, 2017
Hematopoietic stem cells (HSCs) are considered one of the most promising therapeutic targets for the treatment of various blood disorders. However, due to difficulties in establishing stable maintenance and expansion of HSCs in vitro, their insufficient ...
Ema, Hideo, Ieyasu, Aki, Ishida, Reiko, Kimura, Takaharu, Lai, Chen-Yi, Morita, Maiko, Nakamura, Yukio, Nakauchi, Hiromitsu, Nishimura, Toshinobu, Ohehara, Jun, Otsu, Makoto, Sudo, Kazuhiro, Tajima, Yoko, Wilkinson, Adam C, Yamazaki, Satoshi   +14 more
core   +3 more sources

3D Soft Hydrogels Induce Human Mesenchymal Stem Cells “Deep” Quiescence

Advanced Healthcare Materials, EarlyView.
Three‐dimensional soft hydrogels mimicking the bone marrow niche induce deep quiescence in human mesenchymal stem cells. Unlike 2D culture, 3D matrices halt proliferation, regulate cell‐cycle and quiescence markers, and downregulate mTORC1 signaling, preserving stem cell phenotype and therapeutic potential ex vivo.
David Boaventura Gomes, Timo Rademakers, Ana Filipa Henriques Lourenço, Andrea Calore, Clarissa Tomasina, Denis van Beurden, Jinjie Venema, Bryan Chömpff, Hong Liu, Nicole Bouvy, Sandra Camarero‐Espinosa, Lorenzo Moroni   +11 more
wiley   +1 more source

Non-infectious pulmonary complications of hematopoietic stem cell transplantation [PDF]

, 2014
Noninfectious pulmonary complications of hematopoietic stem cell transplant are currently more prevalent than infectious complications. Unfortunately, the pathophysiology basis is not completely understood.
Baloglu, Orkun, McArthur, Jennifer, Rowan, Courtney   +2 more
core   +1 more source

Immunomodulation Effects of Mesenchymal Stromal Cells on Acute Graft-versus-Host Disease after Hematopoietic Stem Cell Transplantation [PDF]

, 2014
Ke Zhao, Rui Lou, Fen Huang, Yanwen Peng, Zujun Jiang, Ke Huang, Xiuli Wu, Yu Zhang, Zhiping Fan, Hongsheng Zhou, Can Liu, Yang Xiao, Jing Sun, Yangqiu Li, Xiang Peng, Qifa Liu   +15 more
openalex   +1 more source

Opinion: Gavage Administration of MXene as a Route‐Specific Alternative to Intravenous Injection into the Bloodstream of Laboratory Animals for Reducing Systemic Nanotoxicity Risks in Immunosuppression and Post‐Transplantation Models with Bile Acid Modification

Advanced Healthcare Materials, EarlyView.
Recent studies reported immunosuppressive properties of specific MXene nanomaterials. Their intravenous injection into the bloodstream of laboratory animals has been a common delivery method to suppress systemic inflammation and prevent transplant rejection.
Alireza Rafieerad, M. Akif Rahman, Ahmad Amiri   +2 more
wiley   +1 more source

32. Rapamycin Treatment of Hematopoietic Stem Cells Enhances Lentiviral Transduction through Autophagy [PDF]

, 2013

openalex   +1 more source

Recapitulating Endochondral Ossification for Bone Repair: From Development to Engineering Strategy

Advanced Healthcare Materials, EarlyView.
This review summarizes the developmental basis of endochondral ossification (ECO) and its applications in bone tissue engineering (BTE). It first outlines the key biological processes and signaling pathways underlying ECO, then discusses biomaterial‐based engineering strategies derived from these principles, and finally highlights future directions for
Yiqi Su, Zihao He, Qianqian Chen, Long Chen, Caiyi Wei, Zijin Zhou, Jianhao Lin, Hui Li, Dan Xing   +8 more
wiley   +1 more source

Co‐Mutation of ASXL1 and KRAS Defines a Novel Ultra‐Adverse‐Risk Subtype of Acute Myeloid Leukemia in a Large‐Scale Cohort

Cancer Medicine
Background ASXL1 mutation acute myeloid leukemia represents a clinically aggressive subtype with heterogeneous outcomes. Current evidence remains inconclusive regarding the prognostic relevance of the KRAS mutation partner in AML with ASXL1 mutation. The
Yijing Zhao, Ting Zhao, Feifei Tang, Xiaodong Mo, Yingjun Chang, Xiaosu Zhao, Lanping Xu, Yu Wang, Xiaohui Zhang, Hao Jiang, Qian Jiang, Xiaojun Huang, Yuqian Sun   +12 more
doaj   +1 more source

An optimized peptide vaccine strategy capable of inducing multivalent CD8+ T cell responses with potent antitumor effects

OncoImmunology, 2015
Therapeutic cancer vaccines are an attractive alternative to conventional therapies for treating malignant tumors, and successful tumor eradication depends primarily on obtaining high numbers of long-lasting tumor-reactive CD8+ T cells.
Hyun-Il Cho, Soo-Hyun Jung, Hyun-Jung Sohn, Esteban Celis, Tai-Gyu Kim   +4 more
doaj   +1 more source

Hemogenic Endothelial Cells Can Transition to Hematopoietic Stem Cells through a B-1 Lymphocyte-Biased State during Maturation in the Mouse Embryo [PDF]

, 2019
Precursors of hematopoietic stem cells (pre-HSCs) have been identified as intermediate precursors during the maturation process from hemogenic endothelial cells to HSCs in the aorta-gonad-mesonephros (AGM) region of the mouse embryo at embryonic day 10.5.
Azevedo Portilho, Nathalia, Davis, Brian, Hadland, Brandon, Kobayashi, Michihiro, Mishra, Akansha, Tarnawsky, Stefan P., Wei, Haichao, Wenzel, Pamela, Wu, Jiaqian, Yoshimoto, Momoko   +9 more
core   +1 more source