Results 121 to 130 of about 276,679 (267)

Cellular memory and, hematopoietic stem cell aging

, 2006
Hematopoietic stem cells (HSCs) balance self-renewal and differentiation in order to sustain lifelong blood production and simultaneously maintain the HSC pool.
Leonie M. Kamminga, Kamminga, Leonie M., de Haan, Gerald, Gerald de Haan, de Haan, Gerald; id_orcid   +4 more
core   +1 more source

Targeting a Myeloid–Regulatory B Cell Network Reverses Immune Paralysis in Periprosthetic Joint Infections

Advanced Science, EarlyView.
Periprosthetic joint infection establishes a sophisticated immunosuppressive network between CXCR4+ PMN‐MDSCs and Bregs, inducing profound CD8+ T cell paralysis. Alendronate effectively disrupts this CXCR4+ PMN‐MDSC–Breg axis by targeting STAT3, thereby restoring local immune surveillance.
Jintao Wu, Shutao Zhang, Yumin Lin, Juyang Jiao, Zhiwei Fu, Qimin Hong, Ziyi Zhao, Xinhua Qu, Fei Su, Bing Yue   +9 more
wiley   +1 more source

A neutrophil extracellular trap-related risk score predicts prognosis and characterizes the tumor microenvironment in multiple myeloma

Scientific Reports
Multiple myeloma (MM) is a distinguished hematologic malignancy, with existing studies elucidating its interaction with neutrophil extracellular traps (NETs), which may potentially facilitate tumor growth. However, systematic investigations into the role
Zhijia Zhao, Yuan Huo, Yufeng Du, Yanan Huang, Hongchen Liu, Chengtao Zhang, Jinsong Yan   +6 more
doaj   +1 more source

Novelty in improvement of CAR T cell-based immunotherapy with the aid of CRISPR system

Hematology, Transfusion and Cell Therapy
Introduction: Chimeric Antigen Receptor (CAR) T cells have tremendous potentials for cancer treatment; however, various challenges impede their universal use.
Abbas Hajifathali, Maryam Vahdat Lasemi, Maryam Mehravar, Mohammad Reza Moshari, Afshin Mohammad Alizadeh, Elham Roshandel   +5 more
doaj   +1 more source

Human Urine Stem Cells Alleviate Pulmonary Fibrosis via Inhibiting Macrophage‐Myofibroblast Transition

Advanced Science, EarlyView.
Therapeutic role and mechanism of human urine stem cells (hUSCs) in pulmonary fibrosis. hUSCs alleviated pulmonary fibrosis by selectively inhibiting macrophage‐myofibroblast transition (MMT) in two ways: on one hand, hUSCs inhibited mitochondrial reactive oxygen species (mtROS) production and apoptosis/senescence of epithelial cells in pulmonary ...
Zhou‐Hang Zhang, Guan‐Lin Guo, Xiao‐Hui Guan, Min Hu, Qi‐Ming Huang, Ding‐Wen Guo, Hao‐Cheng Gu, You‐Qiong Zhuo, Ning Li, Hong‐Bo Xin, Ke‐Yu Deng   +10 more
wiley   +1 more source

P1302: SALVAGE ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION IS ALSO THE CURATIVE AND SAFE TREATMENT FOR RELAPSED/REFRACTORY ACUTE MYELOID LEUKEMIA IN THE ERA OF TARGETED THERAPY

HemaSphere, 2023
占祥 刘, 二辉 袁, 空 高, 启姝 秦, 琪 王, 艳智 宋, 彤 吴   +6 more
doaj   +1 more source

Hematopoietic Stem Cell Intracellular Levels of Ca2+ to the Rescue! What Next?

, 2019
Calcium ions (Ca2+), ubiquitous signaling and second messenger molecules, are communicators for the transmission of messages in numerous cell functions. In this issue of Cell Stem Cell, Luchsinger et al.
Broxmeyer, Hal E.
core   +1 more source

Beyond Potency: Emerging Determinants and Optimization Strategies Enhancing Therapeutic Efficacy of Adult Stem Cells

Advanced Science, EarlyView.
Adult stem cell therapy requires more than high in vitro potency. This review proposes a systems framework in which cell‐intrinsic programs, instructive microenvironmental cues, and pre‐/post‐delivery engineering are co‐designed under standardized translational rules.
Soo‐Rim Kim, Yun Jae Jung, Hwa‐Yong Lee   +2 more
wiley   +1 more source

Expansão ex vivo de células-tronco/progenitoras hematopoiéticas de sangue de cordão umbilical e placentário [PDF]

, 2014
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Farmácia, Florianópolis, 2014.As Células-tronco progenitoras hematopoiéticas (CTPHs) do sangue de cordão umbilical e placentário (SCUP ...
Benedetti, Aloisio Luiz
core  

CD177 Deficiency Defines a Stable Subtype of Human Neutrophil Granulocytes with Tumor Promoting Activity

Advanced Science, EarlyView.
Human neutrophils exist as two epigenetically imprinted subtypes defined by stable CD177 expression or absence — a ratio that persists across time, circadian rhythms, and inflammation. CD177− neutrophils display a distinct molecular landscape enriched in arginase 1 and lipid metabolism markers, accumulate in head‐and‐neck tumors, and associate with ...
Marcel Jung, Alexander Beer, Susmita Ghosh, Ekaterina Pylaeva, Belal Alshaar, Tobias Tertel, Nils Bastian Leimkühler, Thomas Schroeder, Janine Gronewold, Nina Hagemann, Ayan Mohamud Yusuf, Benedikt Frank, Yiqiao Zhang, Dennis Nagel, Kim Schloeßer, Laura Karsch, Emily Hedtfeld, Sabrina Lohmann, Kathrin Blank, Andreas Kraus, Max Krumbein, Nastassia Kabankova, Hongxiao Wang, Almke Bader, Mathis Richter, Fengjun Zhang, Raphael Chevre, Bernd Giebel, Stephan Lang, Anika Grüneboom, Daniela Maier‐Begandt, Anja Hasenberg, Oliver Soehnlein, Hans Christian Reinhardt, Sven Heiles, Jianxu Chen, Jadwiga Jablonska, Albert Sickmann, Dirk M. Hermann, Matthias Gunzer   +39 more
wiley   +1 more source