Results 171 to 180 of about 276,679 (267)

Humanized immune system animal models and their recent applications

Animal Models and Experimental Medicine, EarlyView.
In this review, we provide an updated and comprehensive overview of the current state of humanized immune system animal model research. We discuss the variety of techniques used to produce humanized mice with their respective strengths and weaknesses, and evaluate the advantages and limitations of these models, including issues with incomplete immune ...
Nicolas Skuli, Rudra B. Amin, A’ishah Bakayoko, Marisa Kruidenier, Sahara Aqui, Sarah J. Skuli, Terence P. Gade   +6 more
wiley   +1 more source

Therapeutic activity of a hematopoietic stem cell-delivered cell-penetrating frataxin in Friedreich's ataxia models. [PDF]

Cell Rep Med
Pido-Lopez J, Moula SE, Shaban E, Stamatiou K, Critchley BJ, Whittaker TE, Svensson S, Anjomani-Virmouni S, Kalef-Ezra E, Carr L, Hassel J, Thrasher AJ, Kurian MA, Blair IA, Rojsajjakul T, Santilli G, Sala A.   +16 more
europepmc   +1 more source

Engraftment of sheep splenic lymphocytes into NBSGW mice and application in Brucella infection

Animal Models and Experimental Medicine, EarlyView.
A sheep splenocyte‐reconstituted mouse model (Sh‐Spl mice) was established via intravenous injection of sheep splenic lymphocytes into immunodeficient mice to evaluate Brucella infection. Abstract Background The development of immune reconstituted xenograft mouse models has addressed the limitations imposed by interspecies immunological differences in ...
Xiaowei Wang, Shicheng Wan, Yanmin Guo, Hongyu Han, Fei Luo, Dongmei Jiang, Xiaorong Yang, Quanhai Pang, Haisheng Yu, Jinlian Hua   +9 more
wiley   +1 more source

Cytomegalovirus reactivation and the prevalence in autologous hematopoietic stem cell transplantation. [PDF]

World J Virol
Mittal A, Hutchinson HJ, Lucke-Wold BP.
europepmc   +1 more source

Nonviral Gold Nanoparticle‐Mediated Delivery of CRISPR‐Cas9 Ribonucleoprotein and Long DNA Transgenes Into Primary Blood Cells

Advanced NanoBiomed Research, EarlyView.
CRISPR/Cas9 has revolutionized the field of gene therapy, but delivery remains an outstanding issue. We propose a nonviral gold‐nanoparticle platform for co‐delivery of CRISPR/Cas9 ribonucleoprotein and long 2.1 kilobase dsDNA transgene constructs. This CRISPR‐AuNP is inexpensive to produce and mediate gene editing and DNA delivery in T cells and CD34+
Rachel A. Cunningham, Karthikeya S. V. Gottimukkala, Daniel D. Lane, Katrina Poljakov, Patricia Lipson, Mark R. Enstrom, Alessandro Rizzi, Aude G. Chapuis, Jennifer E. Adair   +8 more
wiley   +1 more source

Mesangial hyaline degeneration after hematopoietic stem cell transplantation. [PDF]

Kidney Res Clin Pract
Kawaguchi T, Yamaguchi Y.
europepmc   +1 more source

Continuous predictive mortality risk monitoring after allogeneic hematopoietic stem cell transplantation. [PDF]

Sci Rep
Rucks N, Korlakov S, Scharf SA, Rommerskirchen A, Haas R, Conrad S.   +5 more
europepmc   +1 more source

Efficacy and safety analysis of autologous hematopoietic stem cell transplantation for extraocular retinoblastoma. [PDF]

Front Pediatr
Liu H, Tang S, Liu Q, Zhang Y, Liu Y, Fang J, Gong H, Wang C, Liu Z, Sun Y.   +9 more
europepmc   +1 more source

Association of Clonal Hematopoiesis With Incident, Late‐Onset, Seropositive Rheumatoid Arthritis

Arthritis &Rheumatology, EarlyView.
Objective Clonal hematopoiesis (CH), defined by acquired driver mutations in hematopoietic stem cells, is associated with many inflammatory diseases of aging. We investigated whether CH and its subtypes, CH of indeterminate potential (CHIP) and mosaic chromosomal alteration (mCA), are associated with incident rheumatoid arthritis (RA) and whether ...
Kun Zhao, Yash Pershad, J. Brett Heimlich, Michelle Ormseth, C. Michael Stein, Brian Sharber, Caitlyn Vlasschaert, Alexander G. Bick, Robert W. Corty   +8 more
wiley   +1 more source

Synthetic Cell-Based Artificial Stem Cell Niches for Hematopoietic Stem Cell Differentiation. [PDF]

Chembiochem
Balabanov I, Madureira S, Burgstaller A, Fehlberg M, Piernitzki N, Abdukarimov N, Lautenschläger F, Staufer O.   +7 more
europepmc   +1 more source