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The aging of hematopoietic stem cells
Nature Medicine, 1996We have purified hematopoietic stem cells (HSCs) from the bone marrow of old mice and compared their properties to HSCs in young and middle-aged mice. Single, reconstituting HSCs (by limit dilution) from old and young mice exhibited indistinguishable progenitor activities in vivo. HSCs were five times as frequent in the bone marrow of old mice; however,
S J, Morrison +4 more
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The biology of hematopoietic stem cells
Archives of Medical Research, 2003Rarely has so much interest from the lay public, government, biotechnology industry, and special interest groups been focused on the biology and clinical applications of a single type of human cell as is today on stem cells, the founder cells that sustain many, if not all, tissues and organs in the body.
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The Biology of Hematopoietic Stem Cells
Annual Review of Cell and Developmental Biology, 1995Hematopoietic stem cells (HSC) are the only cells in the blood-forming tissues that can give rise to all blood cell types and that can self-renew to produce more HSC. In mouse and human, HSC represent up to 0.05% of cells in the bone marrow. HSC are almost entirely responsible for the radioprotective and short- and long-term reconstituting effects ...
S J, Morrison, N, Uchida, I L, Weissman
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Thrombopoietin and the Hematopoietic Stem Cell
Blood, 1998Abstract: The molecular mechanisms that underlie the favorable effects of thrombopoietin on stem cell survival, selfârenewal, and expansion are unknown. On the basis of known effects of HoxB4, HoxA9, and vascular endothelial cell growth factor on stem cells, we explored whether TPO might affect these pathways.
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Hematopoietic Stem Cell Transplantation
Clinical Journal of Oncology Nursing, 2004Nonniekaye Shelburne +2 more
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Aspartate availability limits hematopoietic stem cell function during hematopoietic regeneration
Cell Stem Cell, 2021Le Qi, Wen Gu, Matthias Eckhardt
exaly
Hematopoietic stem cell transplantation in its 60s: A platform for cellular therapies
Science Translational Medicine, 2018C. Chabannon +8 more
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PU.1 enforces quiescence and limits hematopoietic stem cell expansion during inflammatory stress
Journal of Experimental Medicine, 2021James S Chavez +2 more
exaly