Results 91 to 100 of about 1,162,311 (403)
The Role of Sp1 and Sp3 Transcription Factors in Hematopoiesis [PDF]
, 2013 Hematopoiesis is the generation of all mature blood cells from a rare pool of hematopoietic stem cells (HSCs). These blood cells serve a variety of essential functions in the vertebrate body, including gas transport, defense against pathogens, blood ...
Kulu, D.I. (Divine)
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Targeted Genome Editing in Human Repopulating Hematopoietic Stem Cells
Nature, 2014 Targeted genome editing by artificial nucleases has brought the goal of site-specific transgene integration and gene correction within the reach of gene therapy.
P. Genovese +15 more
semanticscholar +1 more source
Advanced Healthcare Materials, EarlyView.This study develops 3D‐printed Mg‐MC/PLGA scaffolds with varying Mg concentrations (0–20%). The 5% Mg scaffold shows optimal cytocompatibility, osteogenic activity in vitro, and significantly enhances bone regeneration in rabbits, improving bone volume and mechanical strength.
Shihang Liu +9 more
wiley +1 more source
P423: ADAPTING CRISPR CAS9 DROPOUT SCREENS TO IN VIVO PDX MODELS OF ACUTE LEUKEMIAS
HemaSphere, 2022 R. Ludwig +3 more
doaj +1 more source
Haematologica, 2019 Various extrinsic signals tightly control hematopoietic stem cell quiescence. Our recent study showed that hematopoietic stem cells are regulated by a special FoxP3+ regulatory T-cell population with high expression of a hematopoietic stem cell marker ...
Yuichi Hirata +3 more
doaj +1 more source
Identification of stromal cells in spleen which support myelopoiesis [PDF]
, 2019 Stromal cells in spleen organize tissue into red pulp, white pulp and marginal zone, and also interact with hematopoietic cells to regulate immune responses.
Lim, Hong, O'Neill, Helen C
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Advanced Nanoparticle Therapeutics for Targeting Neutrophils in Inflammatory Diseases
Advanced Healthcare Materials, EarlyView.This review highlights recent advances in nanoparticle‐based strategies to modulate neutrophil activity in inflammatory diseases. By targeting inflammatory neutrophils, NET formation, and neutrophil apoptosis or recruitment, these approaches aim to improve therapeutic precision.
Min Ji Byun +9 more
wiley +1 more source
Studies on Genetic Aberrations in Acute Myeloid Leukemia [PDF]
, 2011 Hematopoiesis is the formation of blood cellular components. In mammalian embryonic development, the yolk sac and its vasculature are the source of the first blood cells called hematopoietic stem cells (HSCs) from which all blood cells originate.
Abbas, S. (Saman)
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Advanced Healthcare Materials, EarlyView.Vascularized skin organoids are developed from human induced pluripotent stem cells and contain macrophages, Langerhans cells, and neutrophils. Vascularized skin organoids offer a transformative platform to model skin biology and enable mechanistic investigations of inflammatory and hematologic skin disorders.
Mitchell Mostina +9 more
wiley +1 more source
TET1 inhibits the migration and invasion of cervical cancer cells by regulating autophagy
EpigeneticsMethylation modifications play pertinent roles in regulating gene expression and various biological processes. The silencing of the demethylase enzyme TET1 can affect the expressions of key oncogenes or tumour suppressor genes, thus contributing to ...
Ji Ren +6 more
doaj +1 more source