Results 91 to 100 of about 1,175,170 (409)
Biomimetic Fibrinogen Nanofiber Scaffolds for Vascular Hematopoietic Stem Cell Niche Engineering
Advanced Healthcare Materials, EarlyView.This study presents an advanced in vitro model of the vascular hematopoietic stem cell niche using self‐assembled fibrinogen nanofibers, mimicking the basement membrane in bone marrow (BM) sinusoids. The model supports the coculture of microvascular endothelial cells, stromal cells, and hematopoietic stem and progenitor cells, providing insights into ...
Sophia Lena Meermeyer +4 more
wiley +1 more source
Engineered hematopoietic and immune cells derived from human pluripotent stem cells [PDF]
, 2023 Yun Chang +5 more
openalex +1 more source
Entropy, Ergodicity and Stem Cell Multipotency
, 2015 Populations of mammalian stem cells commonly exhibit considerable cell-cell variability. However, the functional role of this diversity is unclear. Here, we analyze expression fluctuations of the stem cell surface marker Sca1 in mouse hematopoietic ...
Chang, Hannah H. +3 more
core +1 more source
Harnessing Advances in Bone Tissue Engineering for Design of Bone‐on‐Chip Systems
Advanced Healthcare Materials, EarlyView.Bone‐on‐chip (BoC) systems demonstrate significant potential as next‐generation models to study human (patho)physiology and evaluate new therapies. However, progress toward functional, human‐like BoCs has been hindered by the structural and functional complexity of bone. This perspective discusses how insights from bone tissue engineering can guide BoC
Farhad Sanaei +6 more
wiley +1 more source
Advanced Healthcare Materials, EarlyView.Human iPSC‐derived hypertrophic chondrocyte sheet promotes bone regeneration. Abstract Bone defects are a major clinical challenge, primarily owing to the limited self‐healing capacity of bones and the high risk of complications associated with conventional treatment strategies.
Yiwei Chen +9 more
wiley +1 more source
P423: ADAPTING CRISPR CAS9 DROPOUT SCREENS TO IN VIVO PDX MODELS OF ACUTE LEUKEMIAS
HemaSphere, 2022 R. Ludwig +3 more
doaj +1 more source
Haematologica, 2019 Various extrinsic signals tightly control hematopoietic stem cell quiescence. Our recent study showed that hematopoietic stem cells are regulated by a special FoxP3+ regulatory T-cell population with high expression of a hematopoietic stem cell marker ...
Yuichi Hirata +3 more
doaj +1 more source
Targeted Genome Editing in Human Repopulating Hematopoietic Stem Cells
Nature, 2014 Targeted genome editing by artificial nucleases has brought the goal of site-specific transgene integration and gene correction within the reach of gene therapy.
P. Genovese +15 more
semanticscholar +1 more source
Hematopoietic stem cell mobilization
Haematologica, 2008 Recruitment of hematopoietic stem/progenitor cells (HSC) from the bone marrow into peripheral blood following treatment with chemotherapy and/or cytokines is termed mobilization. The release of HSC from the bone marrow is a physiological phenomenon for the protection of HSC from toxic injury ...
LEMOLI, ROBERTO MASSIMO, D'Addio A.
openaire +4 more sources
EBF1-deficient bone marrow stroma elicits persistent changes in HSC potential
, 2020 Crosstalk between mesenchymal stromal cells (MSCs) and hematopoietic stem cells (HSCs) is essential for hematopoietic homeostasis and lineage output. Here, we investigate how transcriptional changes in bone marrow (BM) MSCs result in long-lasting effects
Cauchy, P. +6 more
core +1 more source