Results 101 to 110 of about 394,042 (312)

Radiation‐Resistant Bacteria Deinococcus radiodurans‐Derived Extracellular Vesicles as Potential Radioprotectors

Advanced Healthcare Materials, EarlyView.
Deinococcus radiodurans‐derived extracellular vesicles (R1‐EVs) provide radioprotection against total‐body irradiation‐induced acute radiation syndrome in mice. R1‐EVs mitigate oxidative damage by scavenging free radicals, promoting intestinal repair, enhancing hematopoietic function, and modulating immune responses. This study highlights the potential
Jeong Moo Han, Godfrey Mwiti, Seo‐Joon Yeom, Jaeyoon Lim, Woo Sik Kim, Sangyong Lim, Seung‐Taik Lim, Eui‐Baek Byun   +7 more
wiley   +1 more source

P423: ADAPTING CRISPR CAS9 DROPOUT SCREENS TO IN VIVO PDX MODELS OF ACUTE LEUKEMIAS

HemaSphere, 2022
R. Ludwig, D. Amend, E. Bahrami, I. Jeremias   +3 more
doaj   +1 more source

T-lymphoid differentiation potential measured in vitro is higher in CD34+CD38−/lo hematopoietic stem cells from umbilical cord blood than from bone marrow and is an intrinsic property of the cells

Haematologica, 2011
Background Human bone marrow and umbilical cord blood are sources of allogeneic hematopoietic stem cells for transplantation, which is a life-saving treatment in a variety of diseases but is burdened by delayed T-cell reconstitution.
Magda De Smedt, Georges Leclercq, Bart Vandekerckhove, Tessa Kerre, Tom Taghon, Jean Plum   +5 more
doaj   +1 more source

Hemogenic Endothelial Cells Can Transition to Hematopoietic Stem Cells through a B-1 Lymphocyte-Biased State during Maturation in the Mouse Embryo [PDF]

, 2019
Precursors of hematopoietic stem cells (pre-HSCs) have been identified as intermediate precursors during the maturation process from hemogenic endothelial cells to HSCs in the aorta-gonad-mesonephros (AGM) region of the mouse embryo at embryonic day 10.5.
Azevedo Portilho, Nathalia, Davis, Brian, Hadland, Brandon, Kobayashi, Michihiro, Mishra, Akansha, Tarnawsky, Stefan P., Wei, Haichao, Wenzel, Pamela, Wu, Jiaqian, Yoshimoto, Momoko   +9 more
core   +1 more source

Immunosuppressive Formulations for Immunological Defense against Traumatic Brain Injury

Advanced Healthcare Materials, EarlyView.
A novel subcutaneous formulation combining alpha‐ketoglutarate, glycolysis inhibitor PFK15, and a myelin peptide reduces inflammation in a mouse TBI model. This formulation promotes regulatory immune cells, enhances autophagy, and improves motor function, suggesting its potential as a prophylactic immunosuppressive therapy to mitigate TBI‐induced ...
Kelly Lintecum, Abhirami Thumsi, Kara Dunn, Lindsey Druschel, Sierra Chimene, David Flores Prieto, Amberlyn Simmons, Shivani Mantri, Arezoo Esrafili, Srivatsan J. Swaminathan, Mytreyi Trivedi, Shreya Anandan, Crystal Willingham, Alondra Davila, Sahil Inamdar, Joslyn L. Mangal, Abhirami P. Suresh, Niveda M. Kasthuri, Madan Mohan Chandra Sekhar Jaggarapu, Nicole Appel, Taravat Khodaei, Nathan D. Ng, Alison Sundem, Sanmoy Pathak, George Bjorklund, Jason Newbern, Jeffrey Capadona, Sarah E. Stabenfeldt, Abhinav P. Acharya   +28 more
wiley   +1 more source

Hematopoietic stem and progenitor cells use podosomes to transcellularly cross the bone marrow endothelium

Haematologica, 2020
Bone marrow endothelium plays an important role in the homing of hematopoietic stem and progenitor cells upon transplantation, but surprisingly little is known on how the bone marrow endothelial cells regulate local permeability and hematopoietic stem ...
Timo Rademakers, Marieke Goedhart, Mark Hoogenboezem, Alexander García Ponce, Jos van Rijssel, Maryna Samus, Michael Schnoor, Stefan Butz, Stephan Huveneers, Dietmar Vestweber, Martijn A. Nolte, Carlijn Voermans, Jaap D. van Buul   +12 more
doaj   +1 more source

The distinct nature of hematopoietic stem cell subpopulations studied in long-term stroma-associated culture in the mouse [PDF]

, 1993
In this thesis a number of experiments is described which give evidence for the notion of a distinct nature of CFU-S and cells with LTRA in the mouse. The distinct nature is illustrated by the difference in growth characteristics of CFU-S and LTRA cells ...
Sluijs, J.P. van der
core  

Engineering CAR‐T Therapeutics for Enhanced Solid Tumor Targeting

Advanced Materials, EarlyView.
CART cell therapy has proven effective for blood cancers but struggles with solid tumors due to diverse antigens and complex environments. Recent efforts focus on improving CAR design and validation platforms. Advances in protein engineering, machine learning, and organoid systems aim to enhance CAR‐T therapy against solid tumors.
Danqing Zhu, Won Joon Kim, Hyunjin Lee, Xiaoping Bao, Pilnam Kim   +4 more
wiley   +1 more source

P323: STREAMLINING PRECLINICAL IN VIVO TREATMENT TRIALS BY MULTIPLEXING GENETICALLY LABELLED PDX MODELS OF SEVERAL PATIENTS IN A SINGLE MOUSE

HemaSphere, 2022
K. Hunt, D. Amend, R. Ludwig, B. Vick, A. K. Wirth, T. Herold, I. Jeremias   +6 more
doaj   +1 more source

Saikogenin A improves ethanol-induced liver injury by targeting SIRT1 to modulate lipid metabolism

Communications Biology
Chronic alcohol consumption can lead to alcohol live disease (ALD). Steatosis is a critical hallmark of ALD, making it an important stage for therapeutic intervention.
Mingzhu Jiang, Ying Feng, Jingxian Wang, Xiang Xu, Zegan Liu, Tongfei Li, Shinan Ma, Yufeng Wang, Xingrong Guo, Shiming Du   +9 more
doaj   +1 more source