Results 101 to 110 of about 416,052 (359)

P121 | A VALID PREDICTIVE APPROACH IN PATIENTS WITH CHRONIC LYMPHOCYTIC LEUKEMIA: COMBINATION OF MULTIGENE PROFILING AND HIGH-SENSITIVITY MINIMAL RESIDUAL DISEASE ASSESSMENT

Haematologica
The correlation between the genetic heterogeneity of CLL and clinical diversity still remains unclear, although Next Generation Sequencing (NGS) approaches have contributed to the improvement of such knowledge.
E. Borotti, E. Ronda, A. Scarpa, V. Scaglia, A. Arcari, L. Morello, A. Rossi, D. Vallisa   +7 more
doaj  

ANGPTL8 deficiency attenuates lipopolysaccharide-induced liver injury by improving lipid metabolic dysregulation

Journal of Lipid Research
Liver injury is closely related to poor outcomes in sepsis patients. Current studies indicate that sepsis is accompanied by metabolic disorders, especially those related to lipid metabolism.
Ying Feng, Shan Luo, Chen Fang, Shinan Ma, Dandan Fan, Yanghui Chen, Zhuo Chen, Xiang Zheng, Yijun Tang, Xiaobei Duan, Xingling Liu, Xuzhi Ruan, Xingrong Guo   +12 more
doaj   +1 more source

Microphysiological Systems of Lymphatics and Immune Organs

Advanced Healthcare Materials, EarlyView.
This review surveys recent progress in engineering lymphatic microenvironments and immune organoids within microphysiological systems, emphasizing innovative strategies to recreate the biochemical and biophysical complexity of native lymphatic tissues.
Ishita Jain, Ankur Singh, Andrés J. García   +2 more
wiley   +1 more source

P094 | HIGH-SENSITIVITY DETECTION OF LOW ALLELE FREQUENCY V617F VARIANT IN THE JAK2 GENE USING DIGITAL PCR (DPCR): A NOVEL TOOL FOR DIAGNOSIS OF MYELOPROLIFERATIVE NEOPLASMS

Haematologica
Accurate quantification of the V617F variant in the JAK2 gene using highly sensitive technologies is crucial for the diagnosis, therapeutic monitoring and prognostic assessment of patients with myeloproliferative neoplasms (MPNs).
N. Codeluppi, E. Ronda, A. Schiro, E. Borotti, S. Guidotti, E. Follini, A. Rossi, D. Vallisa   +7 more
doaj  

T-lymphoid differentiation potential measured in vitro is higher in CD34+CD38−/lo hematopoietic stem cells from umbilical cord blood than from bone marrow and is an intrinsic property of the cells

Haematologica, 2011
Background Human bone marrow and umbilical cord blood are sources of allogeneic hematopoietic stem cells for transplantation, which is a life-saving treatment in a variety of diseases but is burdened by delayed T-cell reconstitution.
Magda De Smedt, Georges Leclercq, Bart Vandekerckhove, Tessa Kerre, Tom Taghon, Jean Plum   +5 more
doaj   +1 more source

FHL2 regulates hematopoietic stem cell functions under stress conditions. [PDF]

, 2015
FHL2, a member of the four and one half LIM domain protein family, is a critical transcriptional modulator. Here, we identify FHL2 as a critical regulator of hematopoietic stem cells (HSCs) that is essential for maintaining HSC self-renewal under ...
Chen, J, Fan, R, Hou, Y, Hou, Y, Jiang, Y, Li, L, Li, W, Mittal, N, Peace, D, Qian, Z, Wang, X, Wu, W, Zhu, T   +12 more
core   +2 more sources

Biomimetic Fibrinogen Nanofiber Scaffolds for Vascular Hematopoietic Stem Cell Niche Engineering

Advanced Healthcare Materials, EarlyView.
This study presents an advanced in vitro model of the vascular hematopoietic stem cell niche using self‐assembled fibrinogen nanofibers, mimicking the basement membrane in bone marrow (BM) sinusoids. The model supports the coculture of microvascular endothelial cells, stromal cells, and hematopoietic stem and progenitor cells, providing insights into ...
Sophia Lena Meermeyer, Arundhati Joshi, Constantin von Kaisenberg, Dorothea Brüggemann, Cornelia Lee‐Thedieck   +4 more
wiley   +1 more source

Efficacy and safety of camrelizumab plus apatinib for solid tumors: a meta-analysis

Frontiers in Immunology
ObjectiveThis study used meta-analysis to explore the efficacy and safety of camrelizumab plus apatinib in the treatment of solid tumors.MethodsPubMed, Embase, web of science, and Cochrane library databases were searched for this study, and the searches ...
Ping Yu, Xiaoyu Song, Xiaoyu Song, Yue Li, Xuanlong Chen, Xuanlong Chen, Yuan Zhou, Yuan Zhou, Fei Jiang   +8 more
doaj   +1 more source

Prostaglandin E2 Increases Lentiviral Vector Transduction Efficiency of Adult Human Hematopoietic Stem and Progenitor Cells [PDF]

, 2017
Garrett C. Heffner, Melissa Bonner, Lauryn Christiansen, Francis J. Pierciey, Dakota Campbell, Yegor Smurnyy, Wenliang Zhang, Amanda Hamel, Seema Shaw, Gretchen Lewis, Kendrick A. Goss, Olivia Garijo, Bruce E. Torbett, Holly M. Horton, Mitchell Finer, Philip D. Gregory, Gábor Veres   +16 more
openalex   +1 more source

Improved arteriogenesis with simultaneous skeletal muscle repair in ischemic tissue by SCL plus multipotent adult progenitor cell clones from peripheral blood [PDF]

, 2004
Background: The CD34- murine stem cell line RM26 cloned from peripheral blood mononuclear cells has been shown to generate hematopoietic progeny in lethally irradiated animals.
Gottgens, Berthold, Heil, Matthias, Huss, Ralf, Kinston, Sarah, Moosmann, Sabine, Sagebiel, Sabine, Seliger, Christian, Ziegelhoeffer, Tibor   +7 more
core   +1 more source