Results 11 to 20 of about 1,162,311 (403)

The Impact of Mesenchymal Stem Cells on Differentiation of Hematopoietic Stem Cells [PDF]

Advanced Pharmaceutical Bulletin, 2015
Bone marrow microenvironment contains cellular and acellular compartments. The cellular compartment includes hematopoietic stem cells, mesenchymal stem cells and some other stromal cell types, while the acellular compartment is composed of scaffold ...
Mahshid Saleh, karim Shamsasanjan, Aliakbar Movassaghpourakbari, Parvin Akbarzadehlaleh, Zahra Molaeipour   +4 more
doaj   +2 more sources

Aging of hematopoietic stem cells. [PDF]

Blood, 2018
AbstractHematopoietic stem cells (HSCs) ensure a balanced production of all blood cells throughout life. As they age, HSCs gradually lose their self-renewal and regenerative potential, whereas the occurrence of cellular derailment strongly increases. Here we review our current understanding of the molecular mechanisms that contribute to HSC aging.
G. de Haan, Seka S Lazare
semanticscholar   +5 more sources

GPX4 and vitamin E cooperatively protect hematopoietic stem and progenitor cells from lipid peroxidation and ferroptosis

Cell Death and Disease, 2021
Ferroptosis, a newly defined mode of regulated cell death caused by unbalanced lipid redox metabolism, is implicated in various tissue injuries and tumorigenesis. However, the role of ferroptosis in stem cells has not yet been investigated.
Qian Hu, Yifan Zhang, Huiling Lou, Zexian Ou, Jin Liu, Wentao Duan, Hao Wang, Yuanlong Ge, J. Min, Fudi Wang, Z. Ju   +10 more
semanticscholar   +1 more source

Hematopoietic Stem Cells [PDF]

, 2006
Hematopoietic stem cells (HSCs) have the capacity to self-renew and the potential to differentiate into all of the mature blood cell types. The ability to prospectively identify and isolate HSCs has been the subject of extensive investigation since the first transplantation studies implying their existence almost 50 years ago.
Teresa S. Hawley, Ali Ramezani, Robert G. Hawley   +2 more
openaire   +4 more sources

Combined proteomics and CRISPR‒Cas9 screens in PDX identify ADAM10 as essential for leukemia in vivo

Molecular Cancer, 2023
Background Acute leukemias represent deadly malignancies that require better treatment. As a challenge, treatment is counteracted by a microenvironment protecting dormant leukemia stem cells. Methods To identify responsible surface proteins, we performed
Ehsan Bahrami, Jan Philipp Schmid, Vindi Jurinovic, Martin Becker, Anna-Katharina Wirth, Romina Ludwig, Sophie Kreissig, Tania Vanessa Duque Angel, Diana Amend, Katharina Hunt, Rupert Öllinger, Roland Rad, Joris Maximilian Frenz, Maria Solovey, Frank Ziemann, Matthias Mann, Binje Vick, Christian Wichmann, Tobias Herold, Ashok Kumar Jayavelu, Irmela Jeremias   +20 more
doaj   +1 more source

A reporter system for enriching CRISPR/Cas9 knockout cells in technically challenging settings like patient models

Scientific Reports, 2021
CRISPR/Cas9 represents a valuable tool to determine protein function, but technical hurdles limit its use in challenging settings such as cells unable to grow in vitro like primary leukemia cells and xenografts derived thereof (PDX).
Wen-Hsin Liu, Kerstin Völse, Daniela Senft, Irmela Jeremias   +3 more
doaj   +1 more source

In vivo hematopoietic stem cell modification by mRNA delivery

Science, 2023
Hematopoietic stem cells (HSCs) are the source of all blood cells over an individual’s lifetime. Diseased HSCs can be replaced with gene-engineered or healthy HSCs through HSC transplantation (HSCT).
L. Breda, Tyler E. Papp, M. Triebwasser, A. Yadegari, M. Fedorky, Naoto Tanaka, O. Abdulmalik, G. Pavani, Yongping Wang, S. Grupp, S. Chou, Houping Ni, B. Mui, Ying K. Tam, D. Weissman, S. Rivella, H. Parhiz   +16 more
semanticscholar   +1 more source

Hematopoietic stem cell mobilization

Tzu Chi Medical Journal, 2022
ABSTRACT Hematopoietic stem cell (HSC) transplantation has been used to treat hematopoietic diseases for over 50 years. HSCs can be isolated from bone marrow (BM), umbilical cord blood, or peripheral blood. Because of lower costs, shorter hospitalization, and faster engraftment, peripheral blood has become the predominant ...
Yu-Shan Liou, Der-Shan Sun, Hsin-Hou Chang   +2 more
openaire   +3 more sources

Gene expression profiles and cytokine environments determine the in vitro proliferation and expansion capacities of human hematopoietic stem and progenitor cells

Hematology, 2022
Objective The interplay between intrinsic and extrinsic elements involved in the physiology of hematopoietic cells is not completely understood. In the present study, we analyzed the transcriptional profiles of human cord blood-derived hematopoietic stem
Roberto Dircio-Maldonado, Rosario Castro-Oropeza, Patricia Flores-Guzman, Alberto Cedro-Tanda, Fredy Omar Beltran-Anaya, Alfredo Hidalgo-Miranda, Hector Mayani   +6 more
doaj   +1 more source

DARS2 overexpression is associated with PET/CT metabolic parameters and affects glycolytic activity in lung adenocarcinoma

Journal of Translational Medicine, 2023
Background This study investigated the correlation between the expression of DARS2 and metabolic parameters of 18F-FDG PET/CT, and explored the potential mechanisms of DARS2 affecting the proliferation and glycolysis of lung adenocarcinoma (LUAD) cells ...
Xu-Sheng Liu, Ling-Ling Yuan, Yan Gao, Xing Ming, Yao-Hua Zhang, Yu Zhang, Zi-Yue Liu, Yi Yang, Zhi-Jun Pei   +8 more
doaj   +1 more source