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Heterogeneity of hematopoietic stem cells
Current Opinion in Immunology, 1993Hematopoietic stem cells are capable of multi-lineage differentiation to all blood cell types as well as self-renewal and radioprotection. Thy-1.1lo Lin-/lo Sca-1+ cells are a heterogeneous mixture of quiescent and self-renewing hematopoietic stem cells as well as multi-lineage expanding cells.
Eytan J. Alpern +3 more
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Hematopoietic Stem Cells and Aging
Science of Aging Knowledge Environment, 2002Hematopoiesis is a process by which a single cell--called a hematopoietic stem cell (HSC)--has the proliferative potential to give rise to all of the major lineages of blood and immune cells. Stem cells can undergo both symmetric division, which results in two copies of the parent stem cell, and asymmetric division, which results in self-renewal of the
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Neovascularization and Hematopoietic Stem Cells
Cell Biochemistry and Biophysics, 2011Vasculogenesis and angiogenesis are the major forms of blood vessel formation. Angiogenesis is the process where new vessels grow from pre-existing blood vessels, and is very important in the functional recovery of pathological conditions, such as wound healing and ischemic heart diseases. The development of better animal model and imaging technologies
Hiranmoy Das +2 more
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2012
Hematopoietic stem cells are adult stem cells found mainly in the bone marrow and they provide the blood cells required for daily blood turnover and for fighting infections. Compared to adult stem cells from other tissues, hematopoietic stem cells are easy to obtain, as they can be either aspirated directly out of the bone marrow or stimulated to move ...
Mirjana Pavlovic, Bela Balint
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Hematopoietic stem cells are adult stem cells found mainly in the bone marrow and they provide the blood cells required for daily blood turnover and for fighting infections. Compared to adult stem cells from other tissues, hematopoietic stem cells are easy to obtain, as they can be either aspirated directly out of the bone marrow or stimulated to move ...
Mirjana Pavlovic, Bela Balint
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Hematopoietic stem-cell differentiation
Current Opinion in Immunology, 1991Hematopoietic stem cells can be identified and isolated from hematopoietic tissues of mammalian hosts. Assay systems that solely reflect hematopoietic stem cell activity are being developed, and new cytokines that influence hematopoietic stem-cell proliferation and differentiation have been described.
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Mobilization of hematopoietic stem cells
Blood Reviews, 2000Hematopoietic stem cell transplantation has been extensively exploited as a therapeutic and research modality and has revolutionized current patient care. At present, more and more medical centers use peripheral blood progenitor cells for transplantation by mobilizing hematopoietic stem cells from bone marrow to peripheral blood because of potential ...
Jane L. Liesveld, Siqing Fu
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2020
In vertebrates, the cellular compartment of blood is composed of many different cell types, including lymphocytes (T- and B-cells), Natural Killer (NK) cells, myeloid cells (granulocytes and monocytes/macrophages), erythrocytes (red blood cells), platelets (derived from megakaryocytes) and mast cells.
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In vertebrates, the cellular compartment of blood is composed of many different cell types, including lymphocytes (T- and B-cells), Natural Killer (NK) cells, myeloid cells (granulocytes and monocytes/macrophages), erythrocytes (red blood cells), platelets (derived from megakaryocytes) and mast cells.
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Hematopoietic Stem-Cell Transplantation
New England Journal of Medicine, 2006Hematopoietic stem-cell transplantation, which is used to treat both malignant and nonmalignant conditions, was first conceived more than 50 years ago, but problems associated with transplanting a nonsolid organ and modulating the immune response had to be solved before the procedure could be used clinically.
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Hematopoietic stem cells: An overview
Transfusion and Apheresis Science, 2014Considerable efforts have been made in recent years in understanding the mechanisms that govern hematopoietic stem cell (HSC) origin, development, differentiation, self-renewal, aging, trafficking, plasticity and transdifferentiation. Hematopoiesis occurs in sequential waves in distinct anatomical locations during development and these shifts in ...
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