Results 91 to 100 of about 321 (147)
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Tumor Fluorescence with Hematoporphyrin Derivative
Annals of Otology, Rhinology & Laryngology, 1977Hematoporphyrin derivative (HpD) is one of several photodynamically active dyes that accumulate in tumor cells and can be used to differentiate neoplastic from normal tissue by violet light activation. Degree of tumor fluorescence was studied in relation to the nature of the hematoporphyrin compound, dose of HpD injected, route of injection, and ...
R J, Carpenter +3 more
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Advanced Materials Research, 2013
With the application of 405nm semiconductor laser as a light source, this paper presents the fluorescent characteristics of Hematoporphyrin monomethylether and Hematoporphyrin in the following five solvents: Dimethyl sulfoxide, Dimethylformamide, Tetrahydrofuran, Ethyl acetate and Deionized water.
Mao Tai Zhao, Xiao Feng Yang
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With the application of 405nm semiconductor laser as a light source, this paper presents the fluorescent characteristics of Hematoporphyrin monomethylether and Hematoporphyrin in the following five solvents: Dimethyl sulfoxide, Dimethylformamide, Tetrahydrofuran, Ethyl acetate and Deionized water.
Mao Tai Zhao, Xiao Feng Yang
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Studies on the interaction of hematoporphyrin with hemoglobin
Journal of Photochemistry and Photobiology B: Biology, 1997Spectrophotometric and spectrofluorimetric studies reveal that an interaction occurs between hemoglobin and hematoporphyrin, a photosensitizing drug used in photodynamic therapy. Two concentration ranges of hematoporphyrin, 0.4-0.9 microM and 1.8-3.6 microM, representing significantly monomeric and aggregated (dimeric) state, respectively, have been ...
S, Sil, M, Kar, A S, Chakraborti
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HEMATOPORPHYRIN AS A PHOTOSENSITIZER OF TUMORS*
Photochemistry and Photobiology, 1983Abstract— The ability of hematoporphyrin (Hp) to act as a photosensitizer of cells in vitro or in vivo is a matter of dispute, while hematoporphyrin derivative (Hpd), a mixture of porphyrins including hematoporphyrin, has been consistently found to be an effective photosensitizer both in vitro and in vivo. Until recently the actual component of the Hpd
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The photodynamic modification of DNA by hematoporphyrin
Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1977Illumination (white light: 300-750 nm) of DNA in the presence of hematoporphyrin (less than or equal to 5-10 (-4) M) results in selective degradation of the guanine moiety. DNA so illuminated exhibits physical chemical properties (lowered sedimentation coefficients, lower temperatures of helix-coil transitions, increased buoyant density values ...
B, Gutter, W T, Speck, H S, Rosenkranz
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Journal of Photochemistry and Photobiology B: Biology, 1988
The influence of the polarity of the medium on the efficiency of Type I and Type II photosensitization as carried out by hematoporphyrin and its derivative Photofrin II was studied by EPR techniques. Our results suggest that porphyrin aggregates do not participate as such in the photosensitized processes.
M, Shopova, T, Gantchev
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The influence of the polarity of the medium on the efficiency of Type I and Type II photosensitization as carried out by hematoporphyrin and its derivative Photofrin II was studied by EPR techniques. Our results suggest that porphyrin aggregates do not participate as such in the photosensitized processes.
M, Shopova, T, Gantchev
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Photochemistry and Photobiology, 1987
AbstractA ternary‐solvent HPLC method for analysis of the components of the tumor‐localizing product HPD is described. This HPLC system was used to assess the utility of a new method, based on gel exclusion chromatography, for purification of hematoporphyrin.
D, Kessel, P, Thompson
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AbstractA ternary‐solvent HPLC method for analysis of the components of the tumor‐localizing product HPD is described. This HPLC system was used to assess the utility of a new method, based on gel exclusion chromatography, for purification of hematoporphyrin.
D, Kessel, P, Thompson
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ELECTROPHORESIS, 2005
AbstractAn investigation of the basic factors which govern the microemulsion electrokinetic chromatography (MEEKC) and micellar electrokinetic chromatography (MEKC) separation of Hematoporphyrin D and its base hydrolysis product, hematoporphyrin derivative (HpD), was performed.
Li, Q., Chang, CK, Huie, CW
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AbstractAn investigation of the basic factors which govern the microemulsion electrokinetic chromatography (MEEKC) and micellar electrokinetic chromatography (MEKC) separation of Hematoporphyrin D and its base hydrolysis product, hematoporphyrin derivative (HpD), was performed.
Li, Q., Chang, CK, Huie, CW
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Hematoporphyrin and isohematoporphyrin ethers
International Journal of Biochemistry, 1992Abstract 1. 1. The finding that the action catalysed by HClO4 of the alkylating reagent triethylorthoformate upon isohematoporphyrin and hematoporphyrin results in mono-etherification has been considered in relation to the structure of the porphyrin molecule since simple aromatic phenols such as catechol and saligenin react as expected to yield ...
C. Rimington +3 more
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Hematoporphyrin Derivative Photoradiation Therapy
Archives of Ophthalmology, 1984To the Editor. —I read with interest the article in the JulyArchivesregarding hematoporphyrin derivatives in photoradiation therapy. 1 I found a number of references to this subject appearing in the literature. When I introduced porphyrins to clinical medicine in 1955, at the Johns Hopkins Hospital, Baltimore, 2 I originally used it as a surgical tool.
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