Results 101 to 110 of about 321 (147)
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A Fluorescence Study of Hematoporphyrin
Applied Spectroscopy, 1973The fluorescence characteristics of hematoporphyrin have been studied at 26°C as a function of concentration and pH. The pk values are 4.7 and 8.2 as determined in water and water-ethanol mixtures. The fluorescence spectrum consists of a peak at 625 nm and a second, less intense band at 675 nm.
R. C. Srivastava +2 more
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DETERMINANTS OF HEMATOPORPHYRIN‐CATALYZED PHOTOSENSITIZATION
Photochemistry and Photobiology, 1982Abstract Using murine leukemia L1210 cells in culture, determinants of photosensitization by hemato‐porphyrin were examined. Cells incubated for 10 min with a commercial preparation of hematopor‐phyrin rapidly accumulated protoporphyrin and vinyl‐hydroxyethyldeuteroporphyrin present as impurities.
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SITES OF PHOTOSENSITIZATION BY DERIVATIVES OF HEMATOPORPHYRIN
Photochemistry and Photobiology, 1986AbstractLeukemia L1210 cells were incubatedin vitrowith the tumor‐localizing product HPD (hem‐atoporphyrin derivative) for 0.5. 4 and 18 h. Effects of subsequent irradiation on viability, membrane transport and integrity, DNA synthesis and intracellular ATP concentration were assessed. Intracellular porphyrin pools were analyzed by HPLC.
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Biological Chemistry Hoppe-Seyler, 1991
Rat liver cells incorporate monomeric as well as dimeric hematoporphyrin derivatives. Time-dependent incubation assays gave evidence that monomeric compounds are more efficiently incorporated compared to protoporphyrin dimethyl ester hematoporphyrin ether.
P, Both +4 more
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Rat liver cells incorporate monomeric as well as dimeric hematoporphyrin derivatives. Time-dependent incubation assays gave evidence that monomeric compounds are more efficiently incorporated compared to protoporphyrin dimethyl ester hematoporphyrin ether.
P, Both +4 more
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Hematoporphyrin uptake in atherosclerotic plaques
Neurosurgery, 1988Atherosclerotic plaques were induced in abdominal aortas of rabbits. At 8 weeks, 5 mg of dihematoporphyrin ether (Photofrin II) per kg was injected intravenously followed by sacrifice of the animal, fluorescence microscopy, and quantitative assay of porphyrin in the plaque-containing aortas at 1, 12, 24, 48, and 72 hours.
V, Neave +3 more
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Membrane photosensitization by hematoporphyrin and hematoporphyrin derivative.
Progress in clinical and biological research, 1985HPD-A, the putative active biologic component of HPD, photosensitized lysis of large phosphatidylcholine liposomes and lipid peroxidation in small liposomes with oxygen enhancement ratios from 4 to 5. Unambiguous proof was obtained that this damage was mediated by singlet oxygen.
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Fluorescence of hematoporphyrin in living cells and in solution
Journal of Photochemistry and Photobiology B: Biology, 1988The fluorescence properties of hematoporphyrin (Hp) and its derivative (HpD) were investigated in leukemia cells and in normal lymphocytes under a microscope, and the results were compared with those in solution. The spectra and the time behaviour of Hp (or HpD) fluorescence in living cells were found to be almost the same as those in Hp solution of ...
S, Kinoshita +3 more
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The main photosensitizing components of hematoporphyrin derivative
Cancer Letters, 1982Commercial hematoporphyrin (Hp) and the tumor-localizing and photosensitizing agent hematoporphyrin derivative (Hpd) were analysed by means of high pressure lipid chromatography (HPLC). Furthermore, their efficiencies in sensitizing the photoinactivation of human cells in vitro were compared. The comparison showed that the least polar components of Hpd
J, Moan, T, Christensen, S, Sommer
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Photochemotherapy mediated by hematoporphyrin derivative in gastroenterology
European Journal of Cancer and Clinical Oncology, 1987While results concerning photodynamic treatments of cancers in pneumology or dermatology have been published regularly, few works have been devoted to gastroenterology. Twenty-seven non-operable patients bearing various G.I. tumors of less than 40 mm dia.
T, Patrice +6 more
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57Co-Hematoporphyrin Accumulation by Experimental Tumors
Nuklearmedizin, 1976SummaryThe in vivo distribution of 57Co-hematoporphyrin in adenocarcinoma BW10232-bearing mice has been studied. Tumor-bearing and normal animals exhibit similar patterns of radioactivity accumulation. Twenty-four hours after the administration of the radiocompound the ratios tumor to blood and tumor to muscle indicate a potential value of this ...
L J, Anghileri, M, Heidbreder, R, Mathes
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