Results 261 to 270 of about 339,218 (339)

On the Preparation of Nickel Porphyrins Bearing Two to Four Nitro Groups at β‐Positions

open access: yesEuropean Journal of Organic Chemistry, EarlyView.
The preparation and unambiguous identification via NMR spectroscopy of all six β$\beta$,β‐dinitrometalloporphyrin isomers and three out of fourβ$\beta$,β,β‐trinitrometalloporphyrin isomers are described, along with attempts to prepare β,β,β,β‐tetranitrometalloporphyrins via both direct nitration and condensation of nitropyrroles.
Ameneh Tatar   +8 more
wiley   +1 more source

Emerging Target Discovery Strategies Drive the Decoding of Therapeutic Power of Natural Products and Further Drug Development: A Case Study of Celastrol

open access: yesExploration, EarlyView.
Using celastrol as a case study, this review summarizes various target discovery strategies for natural products, including chemical proteomics, protein microarray, degradation‐based protein profiling, proteome‐wide label‐free approaches, network pharmacology, target‐based drug screening, and indirect strategies.
Yanbei Tu   +5 more
wiley   +1 more source

Curcuma comosa‐Derived Diarylheptanoid Ameliorates Ulcerative Colitis by Inhibiting JNK/NF‐κB and Activating AMPK/Nrf2 Pathways

open access: yesFood Frontiers, EarlyView.
In this study, we isolated and investigated the protective effect of 1,7‐diphenyl‐(6E)‐6‐hepten‐3‐ol (DPHP) against ulcerative colitis. Our results demonstrate that DPHP administration effectively alleviates colitis symptoms, inhibits inflammation, and strengthens antioxidant defense mechanisms. A combination of network pharmacology analysis, molecular
Van‐Long Truong   +2 more
wiley   +1 more source

Structural and clinical characterization of Hb Móstoles (HBA2:c.176A>G; p.His59Arg): a new unstable alpha-globin variant with thalassemic features. [PDF]

open access: yesAm J Blood Res
Ferrer-Benito S   +8 more
europepmc   +1 more source

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