Results 131 to 140 of about 732,679 (273)
ACS Chemical Biology, 2016 Small molecules active in the pathogenic bacterium Staphylococcus aureus are valuable tools for the study of its basic biology and pathogenesis, and many molecules may provide leads for novel therapeutics. We have previously reported a small molecule, 1,
Brendan F. Dutter +6 more
semanticscholar +1 more source
, 1996 Heme oxygenase (HO) converts heme to carbon monoxide (CO) and biliverdin, which is metabolized rapidly to bilirubin. CO is implicated as an intercellular messenger, whereas bilirubin could function as an antioxidant.
George Chiang +2 more
core +1 more source
Data_Sheet_1_Active Turnover of Heme in Hibernation Period in Mammals.DOCX
, 2020 Heme oxygenase (HO)-1 plays an important role during hibernation by catalyzing the degradation of heme to biliverdin/bilirubin, ferrous iron, and carbon monoxide, which activates the protective mechanisms against stress. In this context, it was important
Namki Cho (804957) +3 more
core +1 more source
Phytotherapy Research, EarlyView.Rh1 attenuates oxidative stress and mitochondrial dysfunction through SIRT1‐related signaling. ABSTRACT Alzheimer's disease (AD) remains a progressive neurodegenerative disorder with limited therapeutic options. Ginsenoside Rh1 has been reported to possess neuroprotective properties, yet its specific role and underlying mechanisms in AD are not fully ...
Shi‐Lu Li +10 more
wiley +1 more source
Regulation of Heme Biosynthesis in Neurospora crassa
Journal of Biological Chemistry, 1969 Abstract The mold Neurospora crassa does not accumulate porphyrins in iron deficiency but instead accumulates the sideramine desferricoprogen. In iron deficiency there is an accumulation of δ-aminolevulinic acid and the δ-aminolevulinic acid dehydratase level is very low. A similar situation exists in cobalt toxicity and zinc deficiency.
S, Muthukrishnan +2 more
openaire +2 more sources
Creation of novel pharmacological tools in heme oxygenase research [PDF]
, 2012 Aims: While great strides have been made in the elucidation of the physiological and pharmacological roles of heme oxygenases (HO) in experimental animals and humans, there is still an enormous potential for further research discoveries and their ...
Vukomanovic, Dragic +11 more
core +2 more sources
, 2006 The protein SiaA (Streptococcal iron acquisition) is involved in heme uptake in the bacterium Streptococcus pyogenes. It is difficult to obtain this protein in its fully holo form (completely loaded with heme).
Libkind, Marianna
core +1 more source
Biopolymer‐Based Polyelectrolyte Nanoplatforms for Targeted Photodynamic Therapy of Breast Cancer
VIEW, EarlyView.Illustration of the synthesis of 5‐aminolevulinic acid loaded chitosan‐sericin polyelectrolyte nanoparticles (CSSN/ALA NPs) using the Flash nanocomplexation (FNC) technique and their potential in photodynamic therapy (PDT) against breast cancer (BC). Abstract Nanomedicine has reshaped healthcare, especially in targeted drug delivery systems (DDSs) and ...
Athira Narayanan +14 more
wiley +1 more source
Heme Biosynthesis in Copper Deficient Swine
Experimental Biology and Medicine, 1968 SummaryThe steps in the heme biosynthetic pathway were evaluated in normal and in copper deficient swine. As anemia developed, the activity of heme biosynthetic enzymes increased. These data suggest that the anemia of copper deficiency is not the result of defective heme biosynthesis and, therefore, that copper is not a cofactor in any of the reactions
G R, Lee, G E, Cartwright, M M, Wintrobe
openaire +2 more sources
Heme a Biosynthesis and Trafficking in the Mitochondria
, 2017 Heme is an essential molecule for many cellular functions. However, due to its labile state, tight regulation of its synthesis and trafficking is necessary to prevent the formation of harmful reactive oxygen species.
Swenson, Samantha A
core