Results 131 to 140 of about 44,892 (270)

Mitochondrial ClpX Activates a Key Enzyme for Heme Biosynthesis and Erythropoiesis

, 2017
The mitochondrion maintains and regulates its proteome with chaperones primarily inherited from its bacterial endosymbiont ancestor. Among these chaperones is the AAA+ unfoldase ClpX, an important regulator of prokaryotic physiology with poorly defined ...
Yien, Yvette, Hildick-Smith, Gordon J., Baker, Tania A., Branco, Diana S., Paw, Barry Htin, Rhee, Kevin, Huston, Nicholas C.   +6 more
core   +1 more source

Chrysin Mitigates Acetamiprid‐Induced Testicular Injury in Mice via Suppression of Endoplasmic Reticulum Stress and Inflammation

Environmental Toxicology, EarlyView.
ABSTRACT Acetamiprid (ACP) is a neonicotinoid pesticide that is extensively utilized for the management of insect populations, but its toxic effects on the male reproductive system have become a source of concern. Chrysin (CHR) is a natural flavone found in many plants and bee products, including honey and propolis.
Selim Demir, Nihal Turkmen Alemdar, Esin Yulug, Ali Kulaber, Elif Ayazoglu Demir, Nadire Sevdenur Erdogan, Ahmet Mentese, Yuksel Aliyazicioglu   +7 more
wiley   +1 more source

DHR51 as a coordinator of heme biosynthesis and steroid hormone production to time metamorphosis in Drosophila melanogaster

, 2019
Development from a juvenile to an adult animal is driven by pulses of steroid hormones released at precise developmental times. Inputs from the environment, timing cues, and nutritional factors are all coordinated to produce a steroid hormone pulse ...
Phelps, Brian T.
core   +1 more source

Iron Physiology and Its Impact on Atopic Diseases: An EAACI Taskforce Report

Allergy, EarlyView.
ABSTRACT Iron is essential for oxygen transport, energy metabolism, and immune regulation. Yet iron deficiency is the most common micronutrient disorder across all age groups, affecting nearly one quarter of the global population. Iron deficiency triggers nutritional immunity, a host defense mechanism that withholds and redistributes iron, contributing
Franziska Roth‐Walter, Ioana Agache, Beatriz Cabanillas, Roberto Berni Canani, Pasquale Comberiati, Holger Garn, Cristina Gomez‐Casado, Karin Hufnagl, Ekaterina Khaleva, Gregorio P. Milani, Daniel Munblit, Nikolaos Douladiris, Liam O'Mahony, Frank Redegeld, Carmen Riggioni, Peter K. Smith, Betty van Esch, Emilia Vassilopoulou, Carina Venter, Diego G. Peroni   +19 more
wiley   +1 more source

NirN Protein from Pseudomonas aeruginosa is a Novel Electron-bifurcating Dehydrogenase Catalyzing the Last Step of Heme d(1) Biosynthesis

, 2014
Heme d(1) plays an important role in denitrification as the essential cofactor of the cytochrome cd(1) nitrite reductase NirS. At present, the biosynthesis of heme d(1) is only partially understood.
Weimar, Rebecca, Hoffmann, Martin, Papke, Ulrich, Adamczack, Julia, Haufschildt, Kristin, SEZER, Murat, Kuhlmann, Uwe, Layer, Gunhild, Hildebrandt, Peter, Broering, Martin, Nicke, Tristan, Bröring, Martin   +11 more
core   +1 more source

The role of iron in normal and impaired testicular function

Andrology, EarlyView.
Abstract Iron plays a critical role in testicular physiology, impacting spermatogenesis, testosterone production, and overall testicular function. Iron homeostasis is maintained through systemic and cellular regulatory mechanisms, including hepcidin‐mediated systemic iron control and the iron‐responsive element/iron regulatory protein (IRE/IRP) system ...
Aileen Harrer, Esther G. Meyron‐Holtz, Andreas Meinhardt   +2 more
wiley   +1 more source

Functional Genomics Investigation of Siroheme and Heme d1 Biosynthesis

, 2019
Many bacteria and archaea grow under anaerobic or microaerophilic conditions. In order for these organisms to survive under these conditions, many utilize nitrate or nitrite as terminal electron acceptors for anaerobic respiration.
Owens, Victoria
core  

Fn14 signalling participates in pristane‐induced murine lupus through exacerbating oxidative stress

British Journal of Pharmacology, EarlyView.
Background and Purpose Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by oxidative stress and immune dysregulation. Fibroblast growth factor‐inducible 14 (Fn14) has been implicated in tissue injury, but its specific role in SLE pathogenesis remains unclear.
Zhu Yan, Rongfang Feng, Mai Luo, Yaqi Wang, Min Gao, Qin Chen, Yufei Zhang, Yale Liu, Yumin Xia   +8 more
wiley   +1 more source

Transport of cytochrome c heme lyase [PDF]

, 1983
Neupert, Walter, Hennig, Bernd, Köhler, Helmut, Schweyen, Rudolf J.   +3 more
core   +1 more source

Heme biosynthesis in a chicken hepatoma cell line (LMH): comparison with primary chick embryo liver cells (CELC)

, 2008
5-Aminolevulinic acid synthase (ALA synthase), the rate-controlling enzyme of hepatic heme biosynthesis, is feed-back repressed by heme. In the liver, chemicals such as barbiturates markedly induce ALA synthase, especially in the presence of partial ...
Bonkovsky, Herbert L., Kolluri, Sridevi, Elbirt, Kimberly K.   +2 more
core   +1 more source