Results 111 to 120 of about 732,679 (273)

image_1_Involvement of Small Colony Variant-Related Heme Biosynthesis Genes in Staphylococcus aureus Persister Formation in vitro.tif

, 2021
Background: Persisters are important reasons for persistent infections, and they can lead to antibiotic treatment failure in patients and consequently chronic infection.
Shiyong Wang (1411471), Tao Xu (3537), Wenhong Zhang (207387), Weizheng Li (11195778), Xuyang Wang (1723648), Wenjie Wang (413433), Jiazhen Chen (207371)   +6 more
core   +1 more source

Repurposing antimicrobial agents for neuroprotection: Mechanisms, clinical potential, and challenges

Neuroprotection, EarlyView.
Antimicrobial agents exert neuroprotective effects through modulation of interconnected pathways. Tetracyclines, macrolides, antimalarial agents, sulfones, and antiparasitic agents suppress neuroinflammation, oxidative stress, and apoptosis while preserving mitochondrial function and neurotransmission.
Mohammad Amin Manavi, Mohammadreza Salehi, Razieh Mohammad Jafari, Ramin Goudarzi, Saman Khosravi, Ahmad Reza Dehpour   +5 more
wiley   +1 more source

Heme b in marine cyanobacteria and the (sub-) tropical North Atlantic

, 2012
Heme b is the iron containing prosthetic group to an important pool of iron proteins known as the hemoproteins. Hemoproteins are functionally diverse, playing key roles in photosynthetic and respiratory electron transfer (e.g. cytochrome b6f, photosystem
Honey, David James
core   +1 more source

Heme (dys)homeostasis and liver disease

Frontiers in Physiology
Heme is essential for a variety of proteins involved in vital physiological functions in the body, such as oxygen transport, drug metabolism, biosynthesis of steroids, signal transduction, antioxidant defense and mitochondrial respiration.
Tiago L. Duarte, Tiago L. Duarte, Nicole Viveiros, Catarina Godinho, Catarina Godinho, Delfim Duarte, Delfim Duarte, Delfim Duarte   +7 more
doaj   +1 more source

Reductions in the mitochondrial ABC transporter Abcb10 affect the transcriptional profile of heme biosynthesis genes

Journal of Biological Chemistry, 2017
ATP-binding cassette subfamily B member 10 (Abcb10) is a mitochondrial ATP-binding cassette (ABC) transporter that complexes with mitoferrin1 and ferrochelatase to enhance heme biosynthesis in developing red blood cells.
Alexandra Seguin, Naoko Takahashi‐Makise, Yvette Y. Yien, Nicholas C. Huston, Jared C. Whitman, G. Musso, J. Wallace, Thomas Bradley, H. Bergonia, M. Kafina, Mitsuyo Matsumoto, K. Igarashi, J. Phillips, B. Paw, J. Kaplan, D. Ward   +15 more
semanticscholar   +1 more source

Aspartic Protease Inhibition Induces Proteomic Remodeling in Paracoccidioides brasiliensis

PROTEOMICS, EarlyView.
ABSTRACT Paracoccidioidomycosis (PCM) is a major systemic mycosis in Latin America caused by Paracoccidioides brasiliensis, yet the contribution of aspartic proteases to fungal physiology and pathogenicity remains poorly understood. Here, we employed data‐independent acquisition (DIA)‐based quantitative proteomics to investigate the impact of pepstatin
Sarah Fernandes Lima, Wilson Dias Segura, Leonardo Brogliato de Moraes, Reinaldo Souza Oliveira, Pedro Henrique Corteletti Manfio, Alison Felipe Alencar Chaves, Wagner Luiz Batista   +6 more
wiley   +1 more source

Two Heme-Dependent Terminal Oxidases Power Staphylococcus aureus Organ-Specific Colonization of the Vertebrate Host

mBio, 2013
Staphylococcus aureus is a significant cause of infections worldwide and is able to utilize aerobic respiration, anaerobic respiration, or fermentation as the means by which it generates the energy needed for proliferation.
Neal D. Hammer, Michelle L. Reniere, James E. Cassat, Yaofang Zhang, Amanda O. Hirsch, M. Indriati Hood, Eric P. Skaar   +6 more
doaj   +1 more source

Time‐Resolved Effects of Cold Atmospheric Plasma on E. coli GW‐AmxH19 Transcriptome and Proteome in an Emulated Wastewater Environment

PROTEOMICS, EarlyView.
ABSTRACT Cold atmospheric plasma (CAP) is effective against a variety of microorganisms. Here, we described effects on an Escherichia coli strain isolated from hospital wastewater caused by treatment with physical plasma. E. coli GW‐AmxH19 was incubated in artificial wastewater and treated for 15 min with CAP.
Jörg Bernhardt, Dominik Schneider, Julia Rielicke, Susanne Sievers, Veronika Hahn, Mechthild Bömeke, Anja Poehlein, Dirk Albrecht, Juergen F. Kolb, Katharina Riedel, Rolf Daniel, Daniela Zühlke   +11 more
wiley   +1 more source

Zinc supplementation improves heme biosynthesis in rats exposed to lead

Universa Medicina, 2016
BACKGROUND Lead acetate (Pb) inhibits heme biosynthesis through inhibition of δ-aminolevulinic acid dehydrogenase (δ-ALAD), copro porphyrinogen oxidase, and ferro chelatase. Zinc supplementation increases lead-binding metallothionein proteins.
Budi Santoso, Hertanto Wahyu Subagio, Lisyani Suromo, Henna Rya Sunomo   +3 more
doaj   +1 more source

Novel Mechanisms for Heme-dependent Degradation of ALAS1 Protein as a Component of Negative Feedback Regulation of Heme Biosynthesis*

Journal of Biological Chemistry, 2016
In eukaryotic cells, heme production is tightly controlled by heme itself through negative feedback-mediated regulation of nonspecific 5-aminolevulinate synthase (ALAS1), which is a rate-limiting enzyme for heme biosynthesis.
Y. Kubota, K. Nomura, Y. Katoh, R. Yamashita, K. Kaneko, K. Furuyama   +5 more
semanticscholar   +1 more source