Results 91 to 100 of about 44,892 (270)

Investigating the biosynthesis of heam d1 in pseudomonas aeruginosa: a cofactor for dissimilatory nitrite reductase.

, 2010
PhDHaem d1 is a modified tetrapyrrole unique to the periplasmic enzyme nitrite reductase where it acts in catalysing the reduction of nitrite (NO2 -) to nitric oxide (NO), as part of denitrification.
Parmar-Bhundia, Vina
core  

Fungal Antimicrobial Resistance: Mechanisms, Drivers, and Global Clinical Burden

ChemFoodChem, EarlyView.
ABSTRACT Fungal antimicrobial resistance (AMR) is a growing concern for world health caused by an increase in multidrug‐resistant infections, an increase in environmental reservoirs, and the ineffectiveness of current antifungal treatments. Fungal infections continue to be largely excluded from AMR initiatives while causing over 1.6 million deaths ...
Bikash Baral
wiley   +1 more source

Regulation of Heme Biosynthesis in Neurospora crassa

Journal of Biological Chemistry, 1969
Abstract The mold Neurospora crassa does not accumulate porphyrins in iron deficiency but instead accumulates the sideramine desferricoprogen. In iron deficiency there is an accumulation of δ-aminolevulinic acid and the δ-aminolevulinic acid dehydratase level is very low. A similar situation exists in cobalt toxicity and zinc deficiency.
S, Muthukrishnan, G, Padmanaban, P S, Sarma   +2 more
openaire   +2 more sources

Biomarker‐Based Prediction of OATP1B1 Activity in Clinical Routine—Investigating Coproporphyrins as Markers for Drug–Drug–Gene Interactions

Clinical Pharmacology &Therapeutics, EarlyView.
Coproporphyrin I (CPI) is an established endogenous biomarker for detecting drug–drug interactions (DDIs) involving the hepatic uptake transporter Organic Anion Transporting Polypeptide 1B1 (OATP1B1, gene SLCO1B1). While CPI has been extensively studied in healthy volunteers using controlled pre‐ and post‐OATP1B1‐inhibitor sampling, its applicability ...
Leila Potzel, Anina Zumtaugwald, Anna Bollinger, Chiara Jeiziner, Kurt E. Hersberger, Florine Wiss, Markus L. Lampert, Samuel S. Allemann, Henriette E. Meyer zu Schwabedissen, Céline K. Stäuble   +9 more
wiley   +1 more source

Heme (dys)homeostasis and liver disease

Frontiers in Physiology
Heme is essential for a variety of proteins involved in vital physiological functions in the body, such as oxygen transport, drug metabolism, biosynthesis of steroids, signal transduction, antioxidant defense and mitochondrial respiration.
Tiago L. Duarte, Tiago L. Duarte, Nicole Viveiros, Catarina Godinho, Catarina Godinho, Delfim Duarte, Delfim Duarte, Delfim Duarte   +7 more
doaj   +1 more source

Accumulation of heme biosynthetic intermediates contributes to the antibacterial action of the metalloid tellurite

Nature Communications, 2017
The mechanisms of action of the antibacterial metalloid tellurite are unclear. Here, the authors show that tellurite induces an accumulation of hydroxyl radical and intermediates of heme biosynthesis inE.
Eduardo H. Morales, Camilo A. Pinto, Roberto Luraschi, Claudia M. Muñoz-Villagrán, Fabián A. Cornejo, Scott W. Simpkins, Justin Nelson, Felipe A. Arenas, Jeff S. Piotrowski, Chad L. Myers, Hirotada Mori, Claudio C. Vásquez   +11 more
doaj   +1 more source

Heme biosynthesis and lead anemia

, 2006
鉛貧血については、鉛により赤血球膜の浸透圧に対する脆弱性が増大し、そのため赤血球が破壊することによる溶血性貧血と、ヘム生合成への鉛の阻害作用による貧血の2つの観点から理解される。ここでは、ヘム生合成に影響する鉛による貧血について考察する。The nature of lead anemia is still unknown about its mechanism.
Harada, Koichi, ハラダ, コウイチ, 原田, 幸一   +2 more
core  

Stage‐Dependent Metabolic Reprogramming Drives a Self‐Organizing Microbial Network During Shanxi Aged Vinegar

Food Bioengineering, EarlyView.
Metabolic shifts from growth to stress adaptation in Shanxi aged vinegar fermentation link flavor maturation and microbial cooperation, and Lactobacillus and Acetobacter form a self‐organizing metabolic network through division of labor. ABSTRACT Acetic acid fermentation (AAF) is a vital stage in the production of Shanxi aged vinegar (SAV), during ...
Yanfang Wu, Jing Liu, Dantong Liu, Menglei Xia, Jia Song, Yu Zheng, Min Wang   +6 more
wiley   +1 more source

Two Heme-Dependent Terminal Oxidases Power Staphylococcus aureus Organ-Specific Colonization of the Vertebrate Host

mBio, 2013
Staphylococcus aureus is a significant cause of infections worldwide and is able to utilize aerobic respiration, anaerobic respiration, or fermentation as the means by which it generates the energy needed for proliferation.
Neal D. Hammer, Michelle L. Reniere, James E. Cassat, Yaofang Zhang, Amanda O. Hirsch, M. Indriati Hood, Eric P. Skaar   +6 more
doaj   +1 more source

Broad Spectrum Antibiotic Xanthocillin X Effectively Kills Acinetobacter baumannii via Dysregulation of Heme Biosynthesis

, 2021
Isonitrile natural products exhibit promising antibacterial activities. However, their mechanism of action (MoA) remains largely unknown. Based on the nanomolar potency of xanthocillin X (Xan) against diverse difficult-to-treat Gram-negative bacteria ...
Drechsel, Jonas, Hacker, Stephan M., Rather, Philip N., Shapiro, Justin A., Hübner, Ines, Sieber, Stephan A., Wuest, William M., Hoßmann, Jörn, Pieper, Dietmar H.   +8 more
core   +1 more source