Results 101 to 110 of about 732,679 (273)

table_1_Involvement of Small Colony Variant-Related Heme Biosynthesis Genes in Staphylococcus aureus Persister Formation in vitro.docx

, 2021
Background: Persisters are important reasons for persistent infections, and they can lead to antibiotic treatment failure in patients and consequently chronic infection.
Shiyong Wang (1411471), Tao Xu (3537), Wenhong Zhang (207387), Weizheng Li (11195778), Xuyang Wang (1723648), Wenjie Wang (413433), Jiazhen Chen (207371)   +6 more
core   +1 more source

Bisphenol A and Its Analogs: Toxicity Analysis in Mouse and Rat Liver—A Review

Journal of Applied Toxicology, EarlyView.
ABSTRACT Bisphenol A (BPA) and its analogs are widely recognized for their use in industry and plastic manufacturing. Consequently, humans and animals are continually exposed to various substances in their daily lives. This review evaluates the hepatic toxicity of BPA and its analogs in mice and rats, with particular emphasis on molecular mechanisms ...
Sevda Bagdatli, Muhammed Canik, Gizem Gencay, Nurbanu Zengin, Tarık Dinc, Nazan Deniz Yön   +5 more
wiley   +1 more source

Upregulated heme biosynthesis, an exploitable vulnerability in MYCN-driven leukemogenesis.

JCI Insight, 2017
The increased heme biosynthesis long observed in leukemia was previously of unknown significance. Heme, synthesized from porphyrin precursors, plays a central role in oxygen metabolism and mitochondrial function, yet little is known about its role in ...
Y. Fukuda, Yao Wang, Shang-Li Lian, J. Lynch, S. Nagai, Bruce Fanshawe, A. Kandilci, L. Janke, G. Neale, Yi-Ping Fan, B. Sorrentino, M. Roussel, G. Grosveld, J. Schuetz   +13 more
semanticscholar   +1 more source

Illuminating Streptomyces: Raman Spectroscopy for Antibiotic Detection and Monitoring

Journal of Raman Spectroscopy, EarlyView.
Raman spectroscopy provides a non‐destructive, label‐free approach for studying the chemical diversity of Streptomyces. This review presents its application from detection to chemical characterization of secondary metabolites and monitoring of biosynthetic processes.
Adéla Mikulová, Jan Bobek, Martin Kizovský, Markéta Benešová, Ota Samek, Pavlína Modlitbová, Zdeněk Pilát   +6 more
wiley   +1 more source

Heme biosynthesis in a chicken hepatoma cell line (LMH): comparison with primary chick embryo liver cells (CELC)

, 2008
5-Aminolevulinic acid synthase (ALA synthase), the rate-controlling enzyme of hepatic heme biosynthesis, is feed-back repressed by heme. In the liver, chemicals such as barbiturates markedly induce ALA synthase, especially in the presence of partial ...
Bonkovsky, Herbert L., Kolluri, Sridevi, Elbirt, Kimberly K.   +2 more
core   +1 more source

Proteomic and Metabolomic Profiling Reveal Mitochondrial Transplantation–Mediated Reprogramming in Gastric Cancer Cells

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Mitochondria provide multiple functions for cellular physiology. Transplantation of mitochondria isolated from gastric epithelial cells GES‐1 reducing the malignancy of gastric cancer cells AGS was previously reported. To elucidate the underlying mechanisms, TMT‐based proteomic analysis coupling ingenuity pathway software prediction revealed ...
Ping‐Chen Chen, Chen‐Kai Liu, Ching‐Chung Tsai, Erna Sulistyowati, Fu‐An Li, Chung‐Jung Liu, Deng‐Chyang Wu, Shih‐Hsuan Chou, Fu‐Chen Kuo, Bin Huang   +9 more
wiley   +1 more source

Staphylococcus aureus HemX Modulates Glutamyl-tRNA Reductase Abundance To Regulate Heme Biosynthesis

mBio, 2018
Staphylococcus aureus is responsible for a significant amount of devastating disease. Its ability to colonize the host and cause infection is supported by a variety of proteins that are dependent on the cofactor heme.
Jacob E. Choby, Caroline M. Grunenwald, Arianna I. Celis, S. Gerdes, J. DuBois, Eric P. Skaar   +5 more
semanticscholar   +1 more source

Capture of long‐missing heme oxygenases that degrade both heme b and heme c

mLife, EarlyView.
Abstract Heme serves as a crucial cofactor for hemoproteins and as an iron reservoir; yet, its accumulation is toxic, necessitating efficient degradation pathways. While the catabolism of free heme b is well characterized, the enzymes that disrupt its counterpart covalently tethered to a peptide (heme c) have remained elusive.
Jiyuan Hou, Wenhan Dong, Hui Yang, Yuxuan Liang, Haichun Gao   +4 more
wiley   +1 more source

Accumulation of heme biosynthetic intermediates contributes to the antibacterial action of the metalloid tellurite

Nature Communications, 2017
The mechanisms of action of the antibacterial metalloid tellurite are unclear. Here, the authors show that tellurite induces an accumulation of hydroxyl radical and intermediates of heme biosynthesis inE.
Eduardo H. Morales, Camilo A. Pinto, Roberto Luraschi, Claudia M. Muñoz-Villagrán, Fabián A. Cornejo, Scott W. Simpkins, Justin Nelson, Felipe A. Arenas, Jeff S. Piotrowski, Chad L. Myers, Hirotada Mori, Claudio C. Vásquez   +11 more
doaj   +1 more source

Hepatic 5-aminolevulinic acid synthase mRNA stability is modulated by inhibitors of heme biosynthesis and by metalloporphyrins

, 2008
Hepatic 5-aminolevulinic acid synthase, the first and normally rate-controlling enzyme of heme biosynthesis, is regulated by heme. One of the known mechanisms whereby increased cellular heme regulates 5-aminolevulinic acid synthase is by decreasing the ...
Pepe, Joyce A., Lambrecht, Richard W., Cable, Edward Earl, Bonkovsky, Herbert L., Gildemeister, Otto S., Donohue, Susan E.   +5 more
core   +1 more source