Results 81 to 90 of about 732,679 (273)
mSystems, 2021 Heme is an essential metabolite for most life on earth. Bacterial pathogens almost universally require iron to infect a host, often acquiring this nutrient in the form of heme. The Gram-negative pathogen Pseudomonas aeruginosa is no exception, where heme
David G. Glanville +6 more
doaj +1 more source
Immunity, 2018 &NA; PKC&bgr;‐null (Prkcb−/−) mice are severely immunodeficient. Here we show that mice whose B cells lack PKC&bgr; failed to form germinal centers and plasma cells, which undermined affinity maturation and antibody production in response to immunization.
Carlson Tsui +12 more
semanticscholar +1 more source
Advanced Science, EarlyView.Fluorinated β‐glucan/pectin nanogels enable colon‐targeted oral delivery of astilbin through gastrointestinal protection, β‐glucanase‐responsive release, mucus penetration, and prolonged retention. The released astilbin attenuates senescence‐associated features of CD4+ T cells and promotes Treg responses, while the nanogel matrix modulates the gut ...
Lei Zhao +11 more
wiley +1 more source
The role of ClpX in erythropoietic protoporphyria
Hematology, Transfusion and Cell Therapy, 2018 Hemoglobin is an essential biological component of human physiology and its production in red blood cells relies upon proper biosynthesis of heme and globin protein.
Jared C. Whitman +2 more
doaj +1 more source
Enhanced heme function and mitochondrial respiration promote the progression of lung cancer cells. [PDF]
PLoS ONE, 2013 Lung cancer is the leading cause of cancer-related mortality, and about 85% of the cases are non-small-cell lung cancer (NSCLC). Importantly, recent advance in cancer research suggests that altering cancer cell bioenergetics can provide an effective way ...
Jagmohan Hooda +7 more
doaj +1 more source
Journal of Biological Chemistry, 2019 Apicomplexan parasites such as Toxoplasma gondii possess an unusual heme biosynthesis pathway whose enzymes localize to the mitochondrion, cytosol, or apicoplast, a nonphotosynthetic plastid present in most apicomplexans.
Edwin T. Tjhin +3 more
semanticscholar +1 more source
Heme biosynthesis and lead anemia [PDF]
, 2006 鉛貧血については、鉛により赤血球膜の浸透圧に対する脆弱性が増大し、そのため赤血球が破壊することによる溶血性貧血と、ヘム生合成への鉛の阻害作用による貧血の2つの観点から理解される。ここでは、ヘム生合成に影響する鉛による貧血について考察する。The nature of lead anemia is still unknown about its mechanism.
Harada, Koichi +2 more
core
From Synthesis to Utilization: The Ins and Outs of Mitochondrial Heme
Cells, 2020 Heme is a ubiquitous and essential iron containing metallo-organic cofactor required for virtually all aerobic life. Heme synthesis is initiated and completed in mitochondria, followed by certain covalent modifications and/or its delivery to apo ...
Samantha A. Swenson +5 more
doaj +1 more source
Long non-coding RNA-dependent mechanism to regulate heme biosynthesis and erythrocyte development
Nature Communications, 2018 In addition to serving as a prosthetic group for enzymes and a hemoglobin structural component, heme is a crucial homeostatic regulator of erythroid cell development and function.
Jin-Hua Liu +16 more
semanticscholar +1 more source
Zinc supplementation improves heme biosynthesis in rats exposed to lead [PDF]
Universa Medicina, 2015 Background Lead acetate (Pb) inhibits heme biosynthesis through inhibition of d-aminolevulinic acid dehydrogenase (d-ALAD), copro porphyrinogen oxidase, and ferro chelatase. Zinc supplementation increases lead-binding metallothionein proteins.
Budi Santosa +3 more
doaj +1 more source